Summary
Intra-axonal recordings were obtained in vitro from frog sciatic nerve axons. Adjusting whole nerve stimulation current to just subthreshold for the impaled axon elicited triphasic threshold changes in that axon. Threshold changes were determined by direct intra-axonal current application. Graded subthreshold depolarizations were present in many axons during the passage of action potentials in surrounding axons. When nerve branches were stimulated and axon recordings were obtained from the main nerve trunk, both branches, the one that activated the impaled axon and the one that did not, elicited threshold changes in the impaled axon. These data indicate on a cellular level that impulse activity in an intact nerve bundle can modulate the excitability of adjacent nonactivated fibers.
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References
Arvanitaki A (1942) Effects evoked in an axon by activity of a contiguous one. J Neurophysiol 5: 89–108
Bouton MS, Bittner GD (1981) Regeneration of motor axons in crayfish limbs: Distal stump activation followed by synaptic reformation. Cell Tissue Res 219: 379–392
Chung SH, Raymond SA, Lettvin JY (1970) Multiple meaning in single visual units. Brain Behav Evol 3: 72–101
Clark JW, Plonsey R (1970) A mathematical study of nerve fiber interaction. Biophysical J 10: 937–957
Erulkar SD, Weight FF (1979) Ionic environment and the modulation of transmitter release. Trends Neurosci 2: 298–301
Huizar P, Kuno M, Miyata Y (1975) Electrophysiological properties of spinal motoneurones of normal and dystrophic mice. J Physiol (Lond) 248: 231–246
Katz B, Schmitt OH (1942) A note on interaction between nerve fibers. J Physiol (Lond) 100: 369–371
Kocsis JD, Waxman SG (1980) Absence of potassium conductance in central myelinated axons. Nature 287: 348–349
Korn H, Faber DS (1980) Electrical field effect interactions in the vertebrate brain. Trends Neurosci 3: 6–9
Llinás R, Baker R, Sotelo C (1974) Electronic coupling between neurons in cat inferior olive. J Neurophysiol 37: 560–571
Maeda K, Yagi T, Noguchi A (1980) Induced excitation and synchronization of nerve impulses in two parallel unmyelinated fibers. IEEE Trans Biomed Eng BME-27: 139–145
Malenka RC, Kocsis JD, Ransom BR, Waxman SG (1981) Modulation of parallel fiber excitability by postsynaptically mediated changes in extracellular potassium. Science 214: 339–341
Marrazzi AS, Lorente de Nó R (1944) Interaction of neighboring fibers in myelinated nerve. J Neurophysiol 7: 83–101
Rall W (1977) Core conductor theory and cable properties of neurones. In: Brookhart JM, Mountcastle VB (eds) Handbook of physiology. Sect 1: The nervous system. Am Physiol Soc, Bethesda, MD, pp 39–98
Rasminsky M (1980) Ephaptic transmission between single nerve fibres in the spinal nerve roots of dystrophic mice. J Physiol (Lond) 305: 151–169
Seltzer Z, Devor M (1979) Ephaptic transmission in chronically damaged peripheral nerves. Neurology 29: 1061–1064
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Supported by the Medical Research Service of the Veterans Administration, a grant from the National Multiple Sclerosis Society (RG 1365), and the Culpeper Foundation
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Kocsis, J.D., Ruiz, J.A. & Cummins, K.L. Modulation of axonal excitability mediated by surround electric activity: An intra-axonal study. Exp Brain Res 47, 151–153 (1982). https://doi.org/10.1007/BF00235898
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DOI: https://doi.org/10.1007/BF00235898