Summary
In 15 patients with recurrent ventricular tachycardia, the hemodynamic effects of amiodarone were evaluated under oral loading (1000 mg/day for 14–16 days) and during chronic treatment (600 mg/day for a further 10 weeks). In all patients, coronary artery disease was present with a mean ejection fraction of 37%±10%. The cardiac output during the sinus rhythm, as determined by thermodilution, did not change significantly during loading with amiodarone. During ventricular tachycardia, the cardiac output increased from 3.7 ±1. 3 to 4.5 ± 1.61/min under the influence of amiodarone in 5 patients. Echocardiographic measurements of the left ventricle dimensions did not show a directed change of the end-diastolic and endsystolic diameters and the fraction shortening at the end of the loading period and after 3 months of maintenance therapy. No negative inotropic effect of amiodarone could be demonstrated in patients with recurrent ventricular tachycardia and impaired left ventricular function due to coronary artery disease.
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Abbreviations
- VT:
-
ventricular tachycardia
- bpm:
-
beats per minute
References
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Manz, M., Jung, W. & Lüderitz, B. Hemodynamic effects of amiodarone during acute and chronic treatment in patients with recurrent sustained ventricular tachycardia Received: August 14, 1991. Clin Investig 70, 416–420 (1992). https://doi.org/10.1007/BF00235524
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DOI: https://doi.org/10.1007/BF00235524