Summary
A new type of perisinusoidal cell containing numerous microfilaments is described for the first time. It is found in abundance in the livers of both marine and freshwater fish. These perisinusoidal cells are situated within the space of Disse and adhere firmly through desmosomes both to sinusoidal endothelial cells and to hepatocytes. The cytoplasmic microfilaments are striking and make these cells readily distinguishable from the perisinusoidal fat-storing cells of Ito. Although the function of these cells is not known, the observations presented here suggest that they may provide a supportive framework within the liver.
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References
Grubb, D.L., Jones, A.L.: Ultrastructures of hepatic sinusoids in sheep. Anat. Rec. 170, 75–79 (1971)
Ito, T.: Cytological studies on stellate cells of Kupffer and fat-storing cells in the capillary wall of human liver. Acta Anat. Nippon 26, 2 (1951)
Ito, T.: Recent advances in the study on the fine structure of the hepatic sinusoidal wall; a review. Gunma Rep. Med. Sci. 6, 119–163 (1973)
Ito, T., Shibasaki, S.: Electron microscopic study on the hepatic sinusoidal wall and the fat-storing cells in normal human liver. Arch. Histol. Jap. 29, 137–192 (1968)
Kuhn, N.O., Oliver, M.L.: Ultrastructure of the hepatic sinusoid of goat Capra hercus. J. Cell Biol. 26, 977–979 (1965)
Nopanitaya, W., Grisham, J.W.: Scanning electron microscopy of mouse intrahepatic structures. Exp. Molec. Path. 23, 441–458 (1975)
Wake, K.: “Sternzellen” in the liver; perisinusoidal cells with special reference to storage of vitamin A. Amer. J. Anat. 132, 429–462 (1971)
Widmann, J.J., Cotran, R.S., Fahimi, H.D.: Mononuclear phagocytes (Kupffer cells) and endothelial cells. Identification of two functional cell types in rat liver sinusoids by endogeneous peroxidase activity. J. Cell Biol. 52, 159–170 (1972)
Wisse, E.: Ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J. Ultrastruct. Res. 38, 528–562 (1972)
Wisse, E.: Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells. J. Ultrastruct. Res. 46, 393–426 (1974)
Wisse, E.: Ultrastructure and function of Kupffer cells and other sinusoidal cells in the liver. In: Kupffer cells and other liver sinusoidal cells. (E. Wisse and D.L. Knook, eds.) pp. 33–60. Amsterdam: Elsevier/North-Holland Biomedical Press 1977
Wisse, E., van't Noordende, J.M., van der Meulen, J., Deams, W.Th.: The pit cells: Description of a new cell occuring in rat liver sinusoids and peripheral blood. Cell Tissue Res. 173, 423–435 (1976)
Wood, D.L.: Evidence of species differences in the ultrastructure of the hepatic sinusoid. Z. Zellforsch. 58, 679–692 (1963)
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Supported in part by Grants # GM92 and # ES07017
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Nopanitaya, W., Aghajanian, J., Grisham, J.W. et al. An ultrastructural study on a new type of hepatic perisinusoidal cell in fish. Cell Tissue Res. 198, 35–42 (1979). https://doi.org/10.1007/BF00234832
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DOI: https://doi.org/10.1007/BF00234832