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Target cells for 1,25 dihydroxyvitamin D3 in the pancreas

Cell and Tissue Research volume 209, pages 515–520 (1980)Cite this article

Summary

Mature rats raised on a vitamin D deficient diet were injected with tritium labeled 1,25 dihydroxyvitamin D3. Concentration of radioactivity, which is prevented by pretreatment with unlabeled 1,25 dihydroxyvitamin D3, is found in nuclei of cells that are centrally located in pancreatic islets. The central location of these cells and supportive evidence from the literature suggest that they are B-cells, and that 1,25 dihydroxyvitamin D3 has a direct and genomic action on B-cell functions including insulin secretion.

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Affiliations

  1. Department of Anatomy, University of North Carolina, 111 Swing Building, 27514, Chapel Hill, N.C., USA

    Samuel A. Clark,  Walter E. Stumpf, Madhabananda Sar, Hector F. DeLuca & Yoko Tanaka

  2. Department of Biochemistry, University of Wisconsin, 53706, Madison, WI, USA

    Hector F. DeLuca & Yoko Tanaka

Authors
  1. Samuel A. Clark
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  2. Walter E. Stumpf
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  3. Madhabananda Sar
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  4. Hector F. DeLuca
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  5. Yoko Tanaka
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Supported by US Public Health Service Grants NS 09914 and AM 14881

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Clark, S.A., Stumpf, W.E., Sar, M. et al. Target cells for 1,25 dihydroxyvitamin D3 in the pancreas. Cell Tissue Res. 209, 515–520 (1980). https://doi.org/10.1007/BF00234764

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  • DOI: https://doi.org/10.1007/BF00234764

Key words

  • B-cells
  • 1,25 dihydroxyvitamin D3
  • Autoradiography
  • Pancreaticislets