Summary
Using light microscopic immunohistochemistry, somatostatinpositive structures were observed in the cortex of the rat. These structures, including cells and fibers, are widely distributed in all cortical laminae and are also found in the basal ganglia. The positive results were obtained exclusively in two groups of animals sacrificed during two different months of two subsequent years. The reason for this variability in the immunocytochemical stainability of cortical structures remains enigmatic.
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References
Berelowitz, M., Matthews, J., Pimstone, B.L., Kronheim, S., Sacks, H.: Immunoreactive somatostatin in rat cerebral cortical and hypothalamic synaptosomes. Metabolism 27, Suppl. 1, 1171–1173 (1978)
Brownstein, M., Arimura, A., Sato, H., Schally, A.V., Kizer, J.S.: The regional distribution of somatostatin in the rat brain. Endocrinology 96, 1456–1461 (1975)
Burnweit, C., Forssmann, W.G.: Somatostatinergic nerves in the cervical spinal cord of the monkey. Cell Tissue Res. 200, 83–90 (1979)
Finley, J.C.W., Grossman, G.H., Dimeo, P., Petrusz, P.: Somatostatin-containing neurons in the rat brain: wide-spread distribution revealed by immunocytochemistry after pretreatment with pronase. Am. J. Anat. 153, 483–488 (1978)
Forssmann, W.G., Burnweit, C.: New somatostatinergic systems in the medulla oblongata of the monkey. Cell Tissue Res. (in preparation)
Guillemin, R.: Some thoughts on current research with somatostatin. Metabolism 27, Suppl.1, 1453–1461 (1978)
Krisch, B.: Hypothalamic and extrahypothalamic distribution of somatostatin-immunoreactive elements in the rat brain. Cell Tissue Res. 195, 499–513 (1978)
Krisch, B., Leonhardt, H.: Demonstration of a somatostatin-like activity in cells of the rat retina. Cell Tissue Res. in press
Petrusz, P., Sar, M., Grossman, G.H., Kizer, J.S.: Synaptic terminals with somatostatin-like immunoreactivity in the rat brain. Brain Res. 137, 181–187 (1977)
Straus, W.: Inhibition of peroxidase by methanol and by methanolnitroferricyanid for use in immunoperoxidase procedures. J. Histochem. Cytochem. 19, 682–688 (1971)
Vandesande, F., Dierickx, K.: Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretory system of the rat. Cell Tissue Res. 164, 153–162 (1975)
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Supported by the Deutsche Forschungsgemeinschaft (Grant Nr. Kr 569/3) and Stiftung Volkswagenwerk
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Krisch, B., Leonhardt, H. An intermittent somatostatin-immunoreactivity in the cortex and basal ganglia of the rat. Cell Tissue Res. 205, 327–331 (1980). https://doi.org/10.1007/BF00234691
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DOI: https://doi.org/10.1007/BF00234691