Summary
In the guinea pig myometrium, the adrenergic nerves selectively demonstrated at the ultrastructural level after treatment with 5-OH-DA, show varying degree of degeneration during pregnancy. The changes are more extensive in a late gestational stage (40–45 days) than in an early one (20–25 days), and are particularly evident in the uterus overlying the conceptus as compared to the regions between the fetuses. Scattered degenerative changes were also observed in myometrial specimens from virgin animals, but probably reflect the normal continuous turnover of axons.
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References
Alm, P., Björklund, A., Owman, Ch., Thorbert, G.: Tyrosine hydroxylase and DOPA decarboxylase activities in the guinea-pig uterus: Further evidence for functional adrenergic denervation in association with pregnancy. Neuroscience, accepted for publication (1978a)
Alm, P., Owman, Ch., Sjöberg, N.-O., Thorbert, G.: Uptake and metabolism of 3H-norepinephrine in myometrial adrenergic nerves in the guinea-pig: Effect of pregnancy. Amer. J. Physiol., submitted for publication (1978b)
Barker, D., Ip, M.C.: Sprouting and degeneration of mammalian motor axons in normal and deafferentated skeletal muscle. Proc. roy. Soc. B 163, 538–554 (1966)
Bjerre, B., Wiklund, L., Edwards, D.C.: A study of the de- and regeneration changes in the sympathetic nervous system of the adult mouse after treatment with the antiserum to nerve growth factor. Brain Res. 92, 257–278 (1975)
Draper, R.L.: The prenatal growth of the guinea-pig. Anat. Rec. 18, 369–392 (1920)
Gabella, G.: Structure of the autonomic nervous system. London: Chapman and Hall 1976
Gardmark, S., Owman, Ch., Sjöberg, N.-O.: Recovery of the transmitter content in uterine adrenergic nerves after pregnancy. Amer. J. Obstet. Gynec. 109, 997–1002 (1971)
Kaufmann, P.: Die Meerschweinchenplacenta und ihre Entwicklung. Z. Anat. Entwickl.-Gesch. 129, 83–101 (1969)
Orden, L.S. van, Bensch, K.G., Langer, S.Z., Trendelenburg, U.: Histochemical and fine structural aspects of the onset of denervation supersensitivity in the nictitating membrane of the spinal cat. J. Pharmacol. exp. Ther. 157, 274–283 (1967)
Owman, Ch., Sjöberg, N.-O.: Influence of pregnancy and sex hormones on the system of short adrenergic neurons in the female reproductive tract. Exerpta Med. Int. Congr. Ser. 402, 205–209 (1977)
Owman, Ch., Sjöberg, N.-O., Sjöstrand, N.O.: Short adrenergic neurons, a peripheral neuroendocrine mechanism. In: Amine fluorescence histochemistry (M. Fujiwara and C. Tanaka, eds.), pp. 47–66. Tokyo: Igaku Shoin Ltd. 1974
Thorbert, G., Alm, P., Owman, Ch., Sjöberg, N.-O., Sporrong, B.: Regional changes in the structural and functional integrity of myometrial adrenergic nerves in pregnant guinea-pig, and their relationship to the localization of the conceptus. Acta physiol. scand. 103, 120–131 (1978)
Tranzer, J.P., Richards, G.G.: Fine structural aspects of the effect of 6-hydroxydopamine on peripheral adrenergic neurons. In: 6-hydroxydopamine and catecholamine neurons (T. Malmfors and H. Thoenen, eds.), pp. 15–31. North Holland Publ. Co. 1971
Tranzer, J.P., Thoenen, H.: Ultramorphologische Veränderungen der sympatischen Nervenendigungen der Katze nach Vorbehandlung mit 5-und 6-Hydroxy-Dopamin. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 257, 343–344 (1967)
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Sporrong, B., Alm, P., Owman, C. et al. Ultrastructural evidence for adrenergic nerve degeneration in the guinea pig uterus during pregnancy. Cell Tissue Res. 195, 189–193 (1978). https://doi.org/10.1007/BF00233686
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DOI: https://doi.org/10.1007/BF00233686