Abstract
The present study was designed to examine possible interactions between exogenous CCK and the 5-HT1A receptor subtype mediated serotonergic effects on feeding in rats. The somatodendritic 5-HT1A receptor agonist 8-OH-DPAT (0.32 mg/kg sc) evoked feeding in freely feeding rats. This effect was attenuated by treatment with CCK-8 (1, 5 and 25 μg/kg ip). In food deprived rats, CCK-8 (40 μg/kg ip) significantly reduced the size of a test meal. Treatment with the 5-HT1A receptor antagonist WAY-100135 (10 mg/kg ip) antagonized this anorectic effect of CCK-8. WAY-100135 on its own did not affect food intake. These results suggest the involvement of the 5-HT1A receptor subtype in mediating 5-HT-CCK interactions in the control of food intake in rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bendotti C, Samanin R (1986) 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicits eating in free feeding rats by acting on central serotonin neurons. Eur J Pharmacol 121:147–150.
Blundell JE (1986) Serotonin manipulations and the structure of feeding behaviour. Appetite:7 [Suppl]:39–56
Boden P. Hill RG (1988) Effects of cholecystokinin and related peptides on neuronal activity in the ventromedial nucleus of the rat hypothalamus. Br J Pharmacol 94:256–252
Boden PR, Woodruff GN, Pinnock RD (1991) Pharmacology of a cholecystokinin receptor on 5-hydroxytryptamine neurons in the dorsal raphe of the rat brain. Br J Pharmacol 102:635–638
Branchereau P, Böhme GA, Champagnat J, Moran-Surun MP, Durieux, C, Blanchard, JC, Roques BP, Denavit-Saubié M (1992) CholecytokininA and cholecystokininB receptors in the brainstem solitary complex of the rat: pharmacological identification. J Pharmacol Exp Ther 260:1433–1440
Carlson NR (1991) Physiology of behavior. Allyn and Bacon, Boston, pp 401–433
Cooper SJ (1992) 5-HT and ingestive behaviour. In: Marsden A, Heal DJ (eds) Central serotonin receptors and psychotropic drugs. Blackwell Scientific Pubications, Oxford pp 260–291
Cooper SJ, Dourish CT (1990) Multiple cholecystokinin (cck) receptors and cck-monoamine interaction are instrumental in the control of feeding. Physiol Behav 48:849–857
Crawley JN, Kiss JZ (1985) Tracing the sensory pathway from the gut to brain regions mediating the actions of cholecystokinin on feeding and exploration. Ann NY Acad Sci 448:556–558
Dourish CT, Hutson PH, Curzon G (1985) Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology 86:467–471
Fletcher A, Bill DJ, Bill SJ, Cliffe IA, Dover GM, Forster EA, Haskins TJ, Jones D, Mansell HL, Reilly Y (1993) WAY 100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol 237:283–291
Gibbs J, Smith GP (1991) Cholecystokinin and satiety: problems in brain-gut interactions. In: Taché Y (ed) Brain-gut interactions. CRC Press, Boca Raton, pp. 255–262
Goodall E, Silverstone T (1989) Pharmacological evidence for the involvement of serotonergic mechanisms in human feeding. In: Bevan P, Archer T, Cools AR (eds) Behavioural pharmacology of 5-HT. Erlbaum, Hillsdale, pp 249–257
Harley JE, Fletcher A (1994) The effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on feeding in the rat. Eur J Pharmacol 252:329–332
Hill RG, Boden P (1989) Electrophysiological actions of CCK in the mamallian central nervous system. In: Hughes J, Dockray G, Woodruff G (eds) The neuropeptide cholecystokinin (CCK): Anatomy and biochemistry, receptors, pharmacology and physiology. Ellis Horwood Ltd., Chichester, pp 186–194
Hill DR, Campbell NJ, Shaw TM, Woodruff GN (1987) Autoradiographic localizations and biochemical characterizations of peripheral type CCK receptors in rat CNS using highly selective nonpeptide antagonists. J Neurosci 7:2967–2976
Humphrey PPA, Hartig P, Hoyer D (1993) A proposed new nomenclature for 5-HT receptors. Trends Pharmacol Sci 14:233–236
Hutson PH, Dourish CT, Curzon G (1986) Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. Eur J Pharmacol 129:347–352
Hutson PH, Dourish CT, Curzon G (1988) Evidence that the hyperphagic response 8-OH-DPAT is mediated by 5-HT1A receptors. Eur J Pharmaol 150:361–366
Moran TH, Robinson PH, Goldrich MS, McHugh PR (1986) Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res 362:175–179
Poeschla B, Gibbs J, Simansky KJ, Smith GP (1992) The 5-HT1A agonist 8-OH-DPAT attenuates the satiating actions of cholecystokinin. Pharmacol Biochem Behav 42:541–543
Poeschla B, Gibbs J, Simansky KJ, Greenberg D, Smith GP (1993) Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors. Am J Physiol 264:R62-R64
Routlege C, Gurling J, Wright IK, Dourish CT (1993) Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY 100135: an in vivo microdialysis study. Eur J Pharmacol 239:195–202
Siler AJ, Morley JE (1991) Role of CCK in regulation of food intake. Progr Neurobiol 36: 23–34
Smith GP, Jerome C, Norgren R (1985) Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol 249:R638-R641
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Voigt, JP., Fink, H. & Marsden, C.A. Evidence for the involvement of the 5-HT1A receptor in CCK induced satiety in rats. Naunyn-Schmiedeberg's Arch Pharmacol 351, 217–220 (1995). https://doi.org/10.1007/BF00233239
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00233239