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Mechanism of the ultrastructural changes induced by partial hepatectomy in the STH cells of mice

Cell and Tissue Research volume 206, pages 333–339 (1980)Cite this article

Summary

The ultrastructural changes induced by partial hepatectomy in the STH cells of mice were examined. These changes suggest an increased secretory activity of STH cells. Therefore, several experimental procedures elucidating the possible mechanism of this effect were undertaken. Normal mice were starved for 52 h or treated with insulin, glucagon, or cAMP. Serum glucose level measurements as well as electron microscopy of pituitary STH cells were carried out in each group of animals. It was found that STH cells of glucagon and cAMP-treated mice showed some of the ultrastructural features observed in partially hepatectomized animals.

Hence, serum hyperglucagonemia and increase in pituitary cAMP content, may be important components of the complex mechanism responsible for the ultrastructural changes in STH cells brought about by partial hepatectomy.

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Affiliations

  1. Centro de Endocrinología Experimental y Aplicada (CENEXA) e Instituto de Embriología, Biología, istología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina

    César L. Gómez Dumm, M. Souto &  Juan José Gagliardino

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  1. César L. Gómez Dumm
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  2. M. Souto
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  3. Juan José Gagliardino
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Additional information

This Research was partially supported by funds from CIC, Pcia de Bs.As. The authors wish to thank Mrs. Elma P. de Gagliardino and Mrs. Susana Rivas for excellent technical assistance

Members of Carrera del Investigador del CONICET (Argentina)

Fellow from CIC, Pcia de Bs.As.

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Gómez Dumm, C.L., Souto, M. & José Gagliardino, J. Mechanism of the ultrastructural changes induced by partial hepatectomy in the STH cells of mice. Cell Tissue Res. 206, 333–339 (1980). https://doi.org/10.1007/BF00232776

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Key words

  • STH cells
  • cAMP
  • Glucagon
  • Partial hepatectomy