Summary
In rat pancreatic islets, the apparent space of distribution of galactose is not different from that of other hexoses. In homogenates of islets or tumoral insulin-producing cells, galactose is phosphorylated at a very low rate relative to either glucose phosphorylation in the same tissues or galactose phosphorylation by liver homogenates. In intact islets, galactose increases modestly the glucose 6-phosphate content and is oxidized at a much lower rate than glucose. Galactose slightly increases insulin output in the presence of a stimulatory concentration of glucose but fails to provoke insulin release in the absence of glucose, whether in islets removed from rats fed a normal or galactose-rich diet. The low rate of galactose oxidation and its poor insulinotropic capacity appear attributable to the weak activity of galactokinase in pancreatic islets.
Similar content being viewed by others
References
Ashcroft SJH, Bassett JM, Randle PJ: Diabetes 21 (suppl. 2):538–545, 1972.
Malaisse-Lagae F, Malaisse WJ: Endocrinology 88:72–80, 1971.
Malaisse WJ, Pipeleers DG, Van Obberghen E, Somers G, Devis G, Marichal M, Malaisse-Lagae F: Amer Zool 13:605–612, 1973.
Ashcroft SJH, Bunce J, Lowry M, Hansen SE, Hedeskov CJ: Biochem J 174:517–526, 1978.
Pipeleers DG, Marichal M, Malaisse WJ: Endocrinology 93:1001–1011, 1973.
Grill V, Cerasi E: Biochim biophys Acta 437:36–50, 1976.
Henquin JC: Biochem J 186:541–550, 1980.
Ashcroft SJH, Weerasinghe LCC, Randle PJ: Biochem J 132:223–231, 1973.
Malaisse-Lagae F, Sener A, Malaisse WJ: Biochimie 64: 1059–1063, 1982.
Setter A, Levy J, Malaisse WJ, Biochem J 156:521–525, 1976.
Hellerström C, Marsden NVB: Physiol Chem Phys 14:495–502, 1982.
Lacy P, Kostianovsky M: Diabetes 16:35–39, 1967.
Oie HK, Gazdar AE, Minna JD, Weir GC, Baylin SB: Endocrinology 112:1070–1075, 1983.
Malaisse WJ, Sener A, Welsh M, Malaisse-Lagae F, Hellerström C, Christophe J: Biochem J 210:921–927, 1983.
Giroix M-H, Sener A, Pipeleers DG, Malaisse WJ: Biochem J 223:447–453, 1984.
Carpinelli AR, Sener A, Herchuelz A, Malaisse WJ: Metab Clin Exp 29:540–545, 1980.
Malaisse WJ, Brisson GR, Malaisse-Lagae F: J Lab Clin Med 76:895–902, 1970.
Malaisse WJ, Boschero AC, Kawazu S, Hutton JC: Pflügers Arch 373:237–242, 1978.
Malaisse WJ: Diabetologia 9:167–173, 1973.
Beutler E, Paniker NV, Trinidad F: Biochem Med 5:325–332, 1971.
Hoffman WS: J Biol Chem 120:51–55, 1937.
Bergmeyer HU, Bern E: Methods of Enzymatic Analysis (Bergmeyer H U, ed.) Vol. 3, pp. 1204–1214, Academic Press, New York, 1974.
Malaisse WJ, Malaisse-Lagae F, Wright PH: Am J Physiol 213:843–848, 1967.
Grey NJ, Goldring S, Kipnis DM: J Clin Invest 49:881–889, 1970.
Hellman B, Sehlin J, Täljedal I-B: Biochim biophys Acta 241:147–154, 1971.
Ballard FJ: Biochem J 98:347–352, 1966.
Sols A, Crane RK: J Biol Chem 210:581–595, 1954.
Salas J, Salas M, Vinuela E, Sols A: J Biol Chem 240:1014–1018, 1965.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giroix, MH., Malaisse-Lagae, F., Sener, A. et al. Hexose metabolism in pancreatic islets. — Galactose transport, phosphorylation and oxidation. Mol Cell Biochem 66, 61–64 (1985). https://doi.org/10.1007/BF00231824
Issue Date:
DOI: https://doi.org/10.1007/BF00231824