Abstract
The effects of retinoid Ro 10-9359 on normal albino rabbit eyes and antigen-induced intra-ocular inflammations were investigated. The distribution pattern of intravenously applied 3H — Ro 10-9359 correlated well with the sites of pharmacological action. Whereas immunologically naive rabbits showed a uveal uptake of 0.164 ng/g wet wt. tissue when 100 μg of Ro 10-9359 was administered intravenously, accumulation may amount up to 17.46 ng/g in secondary ocular immune responses. Ro 10-9359 accumulated markedly during secondary stimulation in the uvea, preauricular lymph nodes and the spleen. The chemotactic peptide NForm-Leu-Leu-Phe used to incite a hypopyon attracted Ro 10-9359 into the anterior chamber in vivo.
This study indicates that the aromatic retinoid Ro 10-9359 is able to alter certain immune responses and may be involved in intercellular communication during secondary immune responses in the albino rabbit eye.
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Bialasiewicz, A.A., Kopp, U., Mahlstedt, J. et al. Immunomodulating properties and tissue distribution of aromatic retinoids in the immunologically responsive albino rabbit eye. Graefe's Arch Clin Exp Ophthalmol 220, 268–272 (1983). https://doi.org/10.1007/BF00231354
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DOI: https://doi.org/10.1007/BF00231354