Abstract
Effects of neurohypophyseal (NHP) and synthetic analogs on the pupil of the rabbit were explored. This was prompted by the recent emergence of synthetic analogs with selective agonist and antagonist properties. The miotic effect of the NHP was examined in an isolated iris preparation. Minimum concentrations of arginine-vasopressin (AVP) needed to cause threshold pupillary constriction were approximately 10−10 M. The miotic potency of several NHP analogs correlated best with their pressor activity. In addition, the synthetic NHP pressor antagonist d(CH2)5Tyr(Me)AVP specifically antagonized the miotic effect, confirming that a pressorlike receptor mediates this pharmacologic action of the NHP. We also employed the technique of in vivo intravitreal administration of pharmacologic doses of the NHP in the rabbit. Once again, potent miotic activity was demonstrated. The relative miotic potency of the NHP in vivo provided further support to the relationship between the NHP “pressor” receptor and pupillary constriction. We believe that the use of a variety of NHP natural and synthetic analogs may also prove helpful in investigating potential physiological effects of the NHP on other intraocular smooth muscle.
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References
Berde B, Boissonnas RA (1968) Basic pharmacological properties of synthetic analogues and homologues of the neurohypohyseal hormones. In: Berde B (ed) Handbook of experimental pharmacology, XXIII. Springer, New York, pp 802–864
Horowitz J (1981) The effect of neurohypophyseal peptides on the intraocular pressure and pupil of the rabbit. M.D. thesis, Yale University
Kruszynski M, Lammek B, Manning M (1980) Two highly potent antagonists of the vasopressor response to arginine-vasopressin. J Med Chem 23:364–368
Pollock WBI (1920) The action of hypophysin (Pituitrin) upon the pupil of the rabbit. Br J Ophthalmol 4:106–124
Prince J, Eglitin I (1964) The uvea. In: Prince J (ed) The Rabbit in Eye Research. Charles C Thomas, Springfield, Illinois, pp 140–173
Schlaeppi V (1940) De l'influence des extraits post-hypophysaires sur la pupille et la tension intraoculaire. Ophthalmologica 100:321–344
Sears ML (1973) Adrenergic supersensitivity of the scorbutic iris. Trans Am Ophthalmol Soc 71:536–557
Soloway MR, Stjernschantz J, Sears ML (1981) The miotic effect of substance P on the isolated rabbit iris. Invest Ophthalmol Vis Sci 20:47–52
Swan KC, Myers HB (1936) Response of the iris to Pitressin and Pitocin. Proc Soc Exp Biol Med 34:680–681
Vavra I, Machova A, Holecek V, Cort JH, Zaoral M, Sorm F (1968) Effect of a synthetic analogue of vasopressin in animals and in patients with diabetes insipidus. Lancet 1:948–952
Zwiauer A, Bornschein H (1949) Beitrag zur Frage pharmakologischer Beeinflußbarkeit der Choroidalgefäße. v Graefe's Archive for Clin Exp Ophthalmol 149:407–412
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This work was supported in part by USPHS grants EY00785 and EY00237, Research to Prevent Blindness, Inc., Connecticut Lions Eye Research Foundation, Inc. and a James Hudson Brown Fellowship from Yale University
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Horowitz, J., Sears, M. Neurohypophyseal peptides and the eye: use of synthetic analogs in analyzing effects on the pupil. Graefe's Arch Clin Exp Ophthalmol 220, 253–256 (1983). https://doi.org/10.1007/BF00231351
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DOI: https://doi.org/10.1007/BF00231351