Abstract
Histological and physiological evidence suggests that in pulmonary ooedema the sequence of fluid accumulation in the lung is quantal (all-or-one). We have proposed that increased variation in radiographic density with respiration in pulmonary oedema can be attributed to quantal alveolar behaviour: the more severe the oedema, the greater the variation. To test this hypothesis CT scans of the chest were performed in 5 pigs on inspiratory and expiratory breath-holding at baseline and at various degrees of oleic acid pulmonary oedema. Extravascular lung water (EVLW) was monitored with the double indicator dilution technique to match these observations. At baseline, during induction and throughout the course of pulmonary oedema variation of radiographic attenuation with respiration correlated well with EVLW (R = 0.98). With extensive alveolar oedema this variation did not match EVLW. It is concluded that the principle of quantal alveolar behaviour is a useful model for analysis of pulmonary oedema and its realtionship with respiration.
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Wegenius, G., Wickerts, C.J. & Hedenstierna, G. Radiological assessment of pulmonary oedema: a new principle. Oleic acid lung injury. Eur. Radiol. 4, 146–154 (1994). https://doi.org/10.1007/BF00231201
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DOI: https://doi.org/10.1007/BF00231201