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The measles virus

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Summary

Measles is one of widely spread virus infections that is a major cause of deaths in some tropical areas. The measles virus is a member of the genus of Morbillivirus of the family of Paramyxoviridae. The virions contain six polypeptides, including one glycoprotein; two of them are surface proteins that possess hemagglutinating and hemolytic activities, one of them is polymerase. Replication of the measles virus is similar to that of other Paramyxoviruses. Besides the acute infection for measles virus a persistent infection is characteristic that affects central nervous system and inner organs. Molecular mechanisms of it were studied and the results are discussed to explain the pathogenesis of subacute sclerosing panencephalitis, systemic lupus erythematosus and other diseasis in which measles or measles-like virus may be involved.

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References

  1. Black F. L., Reissig M. and Melnick J. L., 1959. Measles virus. Adv. Virus Res. 6, 205–227.

    Google Scholar 

  2. Warren J., 1960. The relationships of the viruses of measles, canine distemper and renderput. Adv. Virus. Res. 7, 27–60,

    Google Scholar 

  3. Choppin P. W. and Compans R. W., 1975. Reproduction of Paramyxoviruses. In: Comprehensive Virology by H. Fraenkel-Conrat and R. R. Wagner (eds.), vol 4, Reproduction, pp. 95–178.

  4. Black F. L., 1976. Measles. In: Viral Infections of Humans by A. S. Evans, Plenum Medical Book Co., N.Y. and London.

    Google Scholar 

  5. Fenner F., 1975. The classification and nomenclature of viruses. Intervirology 6, 1–12.

    Google Scholar 

  6. Gibbs E. P., Taylor W. P., Lawman M. J. P. and Bryant J., 1979. Classification of peste des petitsruminants as the fourth member of genus Morbiusvirus. Intervirol. 11,268–274.

    Google Scholar 

  7. Waterson A. P., 1965. Measles virus. Arch. ges. V rusforsch. 16, 57–80.

    Google Scholar 

  8. Norrby E. C. J. and Magnusson P., 1965. Some morphological characteristics of the internal component of measles virus. Arch. ges. Virusforsch. 17, 443–447.

    Google Scholar 

  9. Parfanovich M. L, Zhdanov V. M. and Fadeyeva L. L., 1969. Determination of molecular weight of measles virus RNA by the method of agarose-polyacrylamide gel electrophoresis. In: General Virology, pp. 26-27, Moscow.

  10. Nakai T., Shand F. L., Howatson A. F., 1969. Development of measles virus in vitro. Virology 38, 50–67.

    Google Scholar 

  11. Parfanovich M. L, 1970. Measles virus RNA and its replication in the cell. Doctoral thesis, Moscow.

  12. Hall W. W. and Martin S. J., 1973. Purification and characterization of measles virus. J. Gen. Virol. 19, 175–188.

    Google Scholar 

  13. Waters D. I. and Bussell R. H., 1973. Polypeptide composition of measles and canine distemper viruses. Virol. 55, 554–557

    Google Scholar 

  14. Mountcastle W. E. and Choppin R. W., 1977. A comparison of the polypeptides of four measles virus. strains. Virology 78, 463–474.

    Google Scholar 

  15. Tyrrell D. L. J. and Norrby E., 1978. Polypeptides of measles virus. In: Negative-strand viruses, and the host cell, Acad. Press, 1, N.Y., S.-F., pp. 135–141.

    Google Scholar 

  16. Graves M. C., Silver S. M. and Choppin P. W., 1978. Measles virus polypeptide synthesis in infected cells. Virology 86, 254–263.

    Google Scholar 

  17. Scheid A. and Choppin P. W., 1974. Identification of biologic activities of Paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus. Virology 57, 475–479.

    Google Scholar 

  18. Norrby E. and GollmarY., 1975. Identification of measles-virus-specific hemolysis-inhibiting antibodies separate from hemagglutination-inhibiting antibodies. Infect. Immun. 11, 231–239.

    Google Scholar 

  19. Bergholz C. M., Kiley M. P. and Payne F. E., 1975. Isolation and characterization of temperature-sensitive mutants of measles virus. J. Virol. 16, 192–202.

    Google Scholar 

  20. Kiley M. P., Gray R. H. and Payne F. E., 1974. Replication of measles virus: distinct species of short nucleocapsids in cytoplasmic extracts of infected cells. J. Virol. 13, 721–728.

    Google Scholar 

  21. Hodes D. S., Schnitzer T. J., Kalica A. R., Camargo E. and Chanock R. M., 1975. Inhibition of respiratory syncytial parainfluenza 3 and measles viruses by 2deoxy-d-ghenon. Virology 63, 201–208.

    Google Scholar 

  22. Leonard L. L., ter Meulen V. and Freeman J. M., 1971. In vitro sensitivity of measles virus to 6-azauridine. Proc. Soc. Exp. Biol. Med. 136, 857–862.

    Google Scholar 

  23. Lamb R. A., Mahy B. W. J. and Choppin P. W., 1976. The synthesis of Sendai virus polypeptides in infected cells. Virology 69, 116–131.

    Article  CAS  PubMed  Google Scholar 

  24. Gibson P. E. and Bell T. M., 1972. Persistent infection of measles virus in mouse brain cell cultures infected in vivo. Arch. ges. Virusforsch. 37, 45–53.

    Google Scholar 

  25. Mackimm J. and Rapp F., 1977. Inability of measles virus temperature-sensitive mutants to induce interferon. Virology 76, 409–415.

    Google Scholar 

  26. Raine C. S., Feldman L. A., Sheppard R. D. and Bornstein M. B., 1971. Ultrastructural study of longterm measles infection in cultures of hamster dorsalroot ganglion. J. Virol. 8, 318–329.

    Google Scholar 

  27. Oyanagi S., ter Meulen V., Müller D., Katz M. and Koprowski H., 1970. Electon microscopic observations in subacute slerosing panencephalitis brain cell cultures: their correlation with cyto-chemical and immunocytological findings. J. Virol. 6, 370–379.

    Google Scholar 

  28. Fisher L. A. and Rapp F., 1979. Temperature-dependent expression of measles virus structures proteins in persistently infected cells. Virology 94, 55–60.

    Google Scholar 

  29. Rozenblatt S., Gorecki M., Shure N. and Prives C. L., 1979. Characterization of measles virus-specific proteins synthesized in vivo and in vitro from acutely and persistently infected cells. J. Virol. 29, 1099–1106.

    Google Scholar 

  30. Pirquet C. von., 1908. Das ver Patten der Kutanen Tuberkulin reaction während der masern. Dtsch. med. Wochenschr. 34, 1297–1300.

    Google Scholar 

  31. Brown P., Gajdusek D. C. and Tsai T., 1969. Persistence of measles antibody in the absence of circulating natural virus five years after immunization of an isolated virgin population with Edmonston B vaccine. Am. J. Epidermiol. 90, 514–518.

    Google Scholar 

  32. Jersild C., Ammitzboll T., Clausen J. and Fog T., 1973. Association between HC-A antigens and measles antibody in multiple sclerosis. Lancet I, 151–152.

    Google Scholar 

  33. Joseph B. S., Lampert P. W. and Oldstone B. A., 1975. Replication and persistence of measles virus in defined subpopulations of human leukocytes. J. Virol. 16, 1638–1649.

    Google Scholar 

  34. Zhdanov V. M. and Parfanovich M. I., 1974. Integration of measles virus into DNA of chronically infected cells. Arch. ges. Virusforsch. 45, 225–234.

    Google Scholar 

  35. Simpson R. W. and Imuma M., 1975. Recovery of infectious proviral DNA from mammalians cells infected with respiratory syncytial virus. Proc. Nat. Acad. Sci. USA 72, 3230–3234.

    Google Scholar 

  36. Holland J. J., Villarreal L. P. et al, 1976. Long term persistent vesicular stotnatitis virus and rabies virus infectious of cell in vitro. J. Gen. Virol. 33, 193–211.

    Google Scholar 

  37. Neubert H., 1970. Demonstration of virus-specific RNA and DNA sequences in cell-lines persistently infected with Paramyxovirus (in press).

  38. Azadova N. B., 1979. Paper in preparation.

  39. Oyanagi S., Ter Meulen V., Katz M., and Koprowski H., 1971. Comparison of subacute sclerosing panencephalitis and measles viruses: an electron microscopic study. J. Virol. 7, 176–187.

    Google Scholar 

  40. Hall W. W., Kiessling W. R. and ter Meulen V., 1978. Biochemical comparison of measles and subacute sclerosing panencephalitis (SSPE) viruses. Negative strand viruses, Acad. Press, pp. 143-156.

  41. Hall W. W. and ter Meulen V., 1976. Nature 264, 474–477.

    Google Scholar 

  42. Schluederberg A., Chavanich S., Lipman M. B. and Carter C., 1974. Biochem. Biophys. Res. Comm. 58, 647–651.

    Google Scholar 

  43. Wechsler S. L., Stallrup K. C. and Fieldo B. N., 1978. A comparison of intracellular polypeptides of measles and subacute sclerosing panencephalitis virus. Negative Strand viruses. Acad. Press, pp. 169–180.

  44. Eron L., Sprague J. A., Albrecht P., Dunlap R. C., Hicks J. F. and Aulakh G. S., 1978. Subacute sclerosing panencephalitis: an abortive infection by a measles-like virus. Negative Strand Viruses, Acad. Press, pp. 157–167.

  45. Rima B. K., Martin S. J. and Gould E. A., 1979. A comparison of polypeptides in measles and SSPE virus strains. J. gen. Virol. 42, 603–608.

    Google Scholar 

  46. Rozenblatt S., Koch T., Pinhasi O. and Bratesin S., 1979. Infective substructures of measles virus from acutely and persistently infected cells (in press).

  47. Philips P. E. and Christian C., 1969. Virologic studies in systemic lupus erythematosus. Arthr. and Rheum. 12, 688–689.

    Google Scholar 

  48. Fresco R., 1968. Tubular (myxovirus-like) structures in glomerular deposits from a case of lupus nephritis. Fed. Proc. 27, 246.

    Google Scholar 

  49. Alekberova Z. S., Parfanovich M. I., Nasonova V. A., and Zhdanov V. M., 1975. Molecular pathogenesis of systemic lupus erytheumatosus. Arch. Virol. 47, 109–121.

    Google Scholar 

  50. Adams D. H., 1976. Relation between Carp (multiplesclerosis-associated) agent and multiple sclerosis. Lancet II, 444–446.

    Google Scholar 

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  1. The D. T. Ivanovsky Institute of Virology, 123098, Moscow

    V. M. Zhdanov

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Zhdanov, V.M. The measles virus. Mol Cell Biochem 29, 59–66 (1980). https://doi.org/10.1007/BF00230955

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