Summary
We have studied the physiological properties of ganglion cells in the retina of the cat. The experiments were designed to identify those ganglion cells which project to direction-selective cells in the nucleus of the optic tract (NOT), by demonstrating their antidromic activation at low threshold from an electrode in the NOT. These ganglion cells presumably provide the retinal drive to the optokinetic reflex. Altogether, 11 such ganglion cells were identified in a population of 578 cells studied. All 11 were W-cells, with slow-conducting axons. Five of the 11 had on-centre direction-selective receptive fields; the other 6 had a variety of receptive field patterns. Thus, on centre-selective cells form a much higher proportion of the retinal input to direction-selective cells in the NOT than of the overall ganglion cell population. However, their receptive field properties were too varied fully to account for the selectivity of NOT cells for horizontal stimulus movement. In summary the retinal input to the NOT appears to be formed principally or entirely by W-class ganglion cells, including many which are direction selective. It still seems necessary, however, to postulate, some non-retinal mechanism to account for all the receptive field properties of direction-selective NOT cells.
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References
Ballas I, Hoffmann KP, Wagner H-J (1981) Retinal projection to the nucleus of the optic tract in the cat as revealed by retrograde transport of horseradish peroxidase. Neurosci Lett 26: 197–202
Cleland BG, Levick WR (1974) Properties of rarely encountered types of ganglion cells in the cat's retina and an overall classification. J Physiol 240: 457–492
Collewijn H (1981) The oculomotor system of the rabbit and its plasticity. In: Barlow HB, Bullock H, Florey E, Grüsser O-J, van der Loos H (eds) Studies of brain function, Vol 5. Springer, Berlin Heidelberg New York
Farmer SG, Rodieck RW (1982) Ganglion cells of the cat accessory optic system: morphology and retinal topography. J Comp Neurol 205: 190–198
Fukuda Y, Stone J (1974) Retinal distribution and central projections of Y-, X-, and W-cells of the cat's retina. J Neurophysiol 37: 749–772
Grasse KL, Cynader MS (1984) Electrophysiology of lateral and dorsal terminal nuclei of the cat accessory optic system. J Neurophysiol 51: 276–293
Hayhow WR (1959) An experimental study of the accessory optic fiber system in the cat. J Comp Neurol 115: 187–215
Hoffmann KP (1983) Control of the optokinetic reflex by the nucleus of the optic tract in the cat. In: Hein A, Jeannerod M (eds) Spatially oriented behavior. Springer, New York, pp 135–153
Hoffmann KP, Behrend K, Schoppmann A (1976) A direct afferent visual pathway from the nucleus of the optic tract to the inferior olive in the cat. Brain Res 115: 150–153
Hoffmann KP, Schoppmann A (1975) Retinal input to direction selective cells in the nucleus tractus opticus of the cat. Brain Res 99: 359–366
Hoffmann KP, Schoppmann A (1981) A quantitative analysis of the direction-specific response of neurons in the cat's nucleus of the optic tract. Exp Brain Res 42: 146–157
Oyster CW, Barlow HB (1967) Direction-selective units in rabbit retina: distribution of preferred directions. Science 155: 841–842
Oyster CW, Takahashi E, Collewijn H (1972) Direction-selective retinal ganglion cells and control of optokinetic nystagmus in the rabbit. Vision Res 12: 183–193
Pettigrew JD, Cooper ML, Blasdel GG (1979) Improved use of tapetal reflection for eye position monitoring. Invest Ophthalmol 18: 490–495
Rowe MH, Stone J (1976) Properties of ganglion cells in the visual streak of the cat's retina. J Comp Neurol 169: 99–126
Schoppmann A, Hoffmann KP (1976) Continuous mapping of direction selectivity in the cat's visual cortex. Neurosci Lett 2: 177–181
Schoppmann A (1981) Projections from areas 17 and 18 of the visual cortex to the nucleus of the optic tract. Brain Res 223: 1–17
Simpson JI (1984) The accessory optic system. Ann Rev Neurosci 7: 13–41
Stone J, Fukuda Y (1974) Properties of cat retinal ganglion cells: a comparison of W-cells with X- and Y-cells. J Neurophysiol 37: 722–748
Walberg F, Nordby T, Hoffmann KP, Holländer H (1981) Olivary afferents from the pretectal nuclei in the cat. Anat Embryol 161: 291–304
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Hoffmann, K.P., Stone, J. Retinal input to the nucleus of the optic tract of the cat assessed by antidromic activation of ganglion cells. Exp Brain Res 59, 395–403 (1985). https://doi.org/10.1007/BF00230920
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DOI: https://doi.org/10.1007/BF00230920