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Cerium depresses protein synthesis in cultured cardiac myocytes and lung fibroblasts

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Abstract

The present study examined the effect of Cerium on protein synthesis in cultured cardiac myocytes and lung fibroblasts exposed to normal and markedly subnormal levels of Mg2+. Cerium was found to have a general inhibitory effect on protein synthesis in these cell types, including the synthesis of myofibrillar proteins in the cardiac myocytes. Further, the effect of the metal ion was more pronounced in cells exposed to the Mg2+-deficient medium. The possible implications of the observations are discussed.

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Authors and Affiliations

  1. ICMR Centre for Research in Cardiomyopathy, Sree Chitra Tirunal Institute for Medical Sciences and Technology, 695 011, Trivandrum, India

    K. Shivakumar & R. Renuka Nair

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  1. K. Shivakumar
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  2. R. Renuka Nair
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Shivakumar, K., Nair, R.R. Cerium depresses protein synthesis in cultured cardiac myocytes and lung fibroblasts. Mol Cell Biochem 100, 91–96 (1991). https://doi.org/10.1007/BF00230813

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  • DOI: https://doi.org/10.1007/BF00230813

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