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Bilateral labyrinthectomy in the cat: motor behaviour and quiet stance parameters

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The purpose of this study was to examine the effect of bilateral labyrinthectomy on quiet stance in the freely-standing cat. Since loss of the vestibular end organs produces marked deficits in motor behaviour, including ataxia and problems with balance, we hypothesized that labyrinthectomized animals would show impairment in quantitative measures of stance. Stance was quantified in terms of the ground reaction forces under each limb and the tonic electromyographic (EMG) activity of selected muscles. Animals were labyrinthectomized by drilling into the vestibule and removing the vestibular epithelium. Following lesion, animals were able to stand unsupported on the force platform within 2 days. To our surprise, the lesioned animals showed little change in stance parameters from the control, pre-lesion state. Thus, our hypothesis of changes in stance parameters was not supported. There was no change in the distribution of vertical forces under the limbs and no increase in sway, as measured by the area of excursion of the centre of pressure over time. The horizontal plane forces, which were diagonally directed prior to lesion, became more laterally directed and larger in amplitude. The change in direction persisted even after the animals had fully compensated for the lesion, but the force amplitudes returned to control values within 10–12 days. The change in horizontal force direction was similar to that observed in normal animals that were required to stand with their paws closer than preferred in the sagittal plane (unpublished observations). EMG activity changed in some muscles but not others, and usually transiently. One limb extensor showed decreases in tonic activity (gluteus medius), but other extensors showed increases (vastus medialis, soleus). It is likely that the changes in EMG levels were due to the biomechanics of the stance configuration related to the changes in direction of the horizontal plane forces. Kinematic recordings are needed to address this issue further.

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Author notes

  1. J. M. Macpherson

    Present address: R.S. Dow Neurol. Sci. Inst., Good Samaritan Hospital and Med. Center, 1120 N.W. 20th Ave., 97209, Portland, OR, USA

Authors and Affiliations

  1. Department of Anatomy, Queen's University, Kingston, Ontario, Canada

    D. B. Thomson, J. T. Inglis & J. M. Macpherson

  2. Eye and Ear Institute, University of Pittsburgh, 203 Lothrop St., 15213, Pittsburgh, PA, USA

    R. H. Schor

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  1. D. B. Thomson
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  2. J. T. Inglis
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  3. R. H. Schor
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  4. J. M. Macpherson
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Thomson, D.B., Inglis, J.T., Schor, R.H. et al. Bilateral labyrinthectomy in the cat: motor behaviour and quiet stance parameters. Exp Brain Res 85, 364–372 (1991). https://doi.org/10.1007/BF00229414

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  • DOI: https://doi.org/10.1007/BF00229414

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