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The distribution of blood group antigens in rodent epithelia

Cell and Tissue Research volume 237, pages 111–116 (1984)Cite this article

Summary

The pattern of distribution of antigens cross-reacting with antibodies to human blood group antigens A and B and two precursor molecules was examined by immunofluorescence in the epidermis, oral mucosa and forestomach of rats and mice. Staining for blood group antigen A was negative. In all epithelia examined, blood group antigen B was present at the surface of basal and parabasal cells, and the H antigen at the surface of spinous cells. N-acetyllactosamine was present on the cell membranes in the upper spinous and granular cell layers of epidermis and forestomach epithelium and was not expressed in the oral epithelia except for a limited area in the dorsal tongue epithelium.

Thus, the expression of antigen varies both regionally and, as earlier shown in human epithelium, with the stage of maturation of cells within a given epithelium. The observed sequence of expression of these antigens during maturation differs from that of human epithelia, but the present study provides a basis for further experimental studies of the role of cell surface antigens in epithelial homeostasis and maturation.

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Author information

Affiliations

  1. Royal Dental College, Copenhagen, Denmark

    J. Reibel & E. Dabelsteen

  2. Fred Hutchinsons Cancer Research Center, University of Washington, Seattle, USA

    S. Hakomori

  3. Department of Pathology, University of Virginia Medical Center, Charlottesville, USA

    W. W. Young

  4. College of Dentistry, The University of Iowa, Iowa City, USA

    I. C. Mackenzie

Authors
  1. J. Reibel
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  2. E. Dabelsteen
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  3. S. Hakomori
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  4. W. W. Young
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  5. I. C. Mackenzie
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Reibel, J., Dabelsteen, E., Hakomori, S. et al. The distribution of blood group antigens in rodent epithelia. Cell Tissue Res. 237, 111–116 (1984). https://doi.org/10.1007/BF00229205

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  • DOI: https://doi.org/10.1007/BF00229205

Key words

  • Blood group antigens
  • Skin
  • Oral mucosa
  • Stomach
  • Rodents