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Phosphoinositide-generated messengers in cardiac signal transduction

  • Part I: Basic Mechanisms
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Abstract

A multitude of agonists like e.g. endothelin-I, angiotensin-II, serotonin, thrombin, histamine and vasopressin as well as α1-adrenergic and muscarinic stimulation lead to stimulation of the phosphoinositide cycle in the heart. Besides this seven membrane spanning-domain receptor-coupled stimulation of the key enzyme of the phosphoinositide cycle, phospholipase C-β, another class of hormones, growth factors, also couple to the phosphoinositide cycle, now through receptors with intrinsic tyrosine kinase activity that can phosphorylate and stimulate the phospholipase C-γ isozyme. In this review we summarize the multitude of receptor (sub)types, G-protein-subunit- and phospholipase C-isozymes that are present in the heart. Furthermore, generation of second messengers and cellular responses are described together with the (patho)physiological implications for the heart of phosphoinositide cycle activation and second messenger accumulation.

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  1. Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands

    Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge, Karel Bezstarosti & Jos M. J. Lamers

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  1. Han A. A. van Heugten
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  2. Yvonne E. G. Eskildsen-Helmond
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van Heugten, H.A.A., Eskildsen-Helmond, Y.E.G., de Jonge, H.W. et al. Phosphoinositide-generated messengers in cardiac signal transduction. Mol Cell Biochem 157, 5–14 (1996). https://doi.org/10.1007/BF00227875

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