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Metabolism of energy-yielding substrates in patients with liver cirrhosis

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Abbreviations

REE:

resting energy expenditure

RQ:

respiratory quotient

DIT:

diet induced thermogenesis

TEE:

thermic effect of exercise

SGO:

splanchnic glucose output

HGO:

hepatic glucose output

VLDL:

very low density lipoprotein

References

  1. Avgerinos A, Chu P, Greenfield C, Harry DS, McIntyre N (1983) Plasma lipid and lipoprotein response in alcoholic liver disease. Hepatology 3:349–355

    Google Scholar 

  2. Avgerinos A, Kourti A, Chu P, Harry DS, Raptis S, McIntyre N (1988) Plasma lipid and lipoprotein response to carbohydrate feeding in cirrhotic patients. J Hepatol 6:315–324

    Google Scholar 

  3. Avgerinos A, Harry D, Bomsboula S, Theodossiados E, Komesidou V, Paleikavi A, Raptis S, McIntyre N (1992) The effect of eucaloric high carbohydrate feeding on the circulating levels of glucose, fructose and non-esteridied fatty acids. J Hepatol 14:78–87

    Google Scholar 

  4. Ballmann M, Hartmann H, Deacon CF, Schmidt WE, Conlon JM, Creutzfeld W (1986) Hypersecretion of proinsulin does not explain the hyperinsulinemia of patients with liver cirrhosis. Clin Endocrinol 25:351–361

    Google Scholar 

  5. Baron AD, Brechtel G, Olefsky JM (1986) Rates of non-insulin mediated glucose uptake are elevated in type 2 diabetic subjects. J Clin Invest 76:1782–1788

    Google Scholar 

  6. Beck-Nielsen H, Hother-Nielsen O, Vaag A, Alford F (1994) Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: the role of skeletal muscle glucose uptake and hepatic glucose production in the development of hyperglycaemia. A critical comment. Diabetologia 37:217–221

    Google Scholar 

  7. Böker KHW, Bahr MJ, Pirlich M, Müller MJ (1992) Bedeutung des Ketonkörper-Quotienten bei Patienten mit Lebererkrankungen. Z Gastroenterol 30:106 (abstract)

    Google Scholar 

  8. Bosari S, Maradi C, Chiara O, Bevilacqua G, Nespoli A (1984) Energy expenditure in cirrhotic patients. In: Kleinberger G, Ferenci P, Riederer P, Thaler T (eds) Advances in hepatic encephalopathy and urea cycle diseases. Basel, Karger, pp 674–681

    Google Scholar 

  9. Bosch J, Gomis R, Kravetz D, Casamitjana R, Teres J, Rivera F, Rodes J (1984) Role of spontaneous portal-systemic shunting in hyperinsulinism of cirrhosis. Am J Physiol 247:G206-G212

    Google Scholar 

  10. Brandi LS, Santoro D, Natali A, Altomonte F, Baldi S, Frascerra S, Ferrannini E (1993) Insulin resistance of stress: sites and mechanisms. Clin Sci 85:525–535

    Google Scholar 

  11. Bunout D, Petermann M, Bravo M, Kelly M, Hirsch S, Ugarte G, Iturriago H (1989) Glucose turnover rate and peripheral insulin sensitivity in alcoholic patients without liver damage. Ann Nutr Metab 33:31–38

    Google Scholar 

  12. Cahill GF, Herrera MG, Morgan AP, Soeldner JS, Steinke J, Levy PL, Reichard GA, Kipnis DM (1966) Hormone-fuel interrelationships during fasting. J Clin Invest 45:1751–1769

    Google Scholar 

  13. Campellino B, Bories P, Bornin B, Devanley M, Linsk Jr S, Guillemin A, Wirquin E, Fouet P (1989) Despenses energetiques et utilisation de nutrients chez le cirrhotique a jeun et au repas. Influence de l'hepatite alcoholique et de gravite de maladie. Gastroenterol Clin Biol 13:544–550

    Google Scholar 

  14. Campillo B, Chapelain C, Bouet CJ, Frisdal E, Devanthley M, Bouisseau P, Wirquin E, Atlan G (1990) Hormonal and metabolic changes during exercise in cirrhotic patients. Metabolism 39:18–24

    Google Scholar 

  15. Campillo B, Fouet P, Bonnet C, Atlan G (1990) Submaximal oxygen consumption in liver cirrhosis. Evidence of severe functional aerobic impairment. J Hepatol 10:163–167

    Google Scholar 

  16. Cavallo-Perin P, Cassader M, Bozzo A, Bruno P, Nuccio M, Dallômo M, Marucci M, Pagano G (1985) Mechanism of insulin resistance in liver cirrhosis. Evidence of combined receptor and postreceptor defect. J Clin Invest 75:1659–1665

    Google Scholar 

  17. Ceci F, Muscaritoli M, Canniano C, Cascino A, Familiari M, Rossi Fanelli F (1988) Effect of exogenous triglyceride infusion on plasma amino acid profile in liver cirrhosis. Clin Nutr 7:1511–1516

    Google Scholar 

  18. Cerra FB (1987) Hypermetabolism, organ failure, and metabolic support. Surgery 101:1–14

    Google Scholar 

  19. Cohn C (1942) Sodium lactate tolerance as a test of hepatic function. Arch Intern Med 70:829–835

    Google Scholar 

  20. Cooper AD (1990) Hepatic lipoprotein and cholesterol metabolism. In: Zakim D, Boyer TD (eds) Hepatology: a textbook of liver disease, vol 1. Saunders, Philadelphia, pp 96–123

    Google Scholar 

  21. Creutzfeld W, Hartmann H, Nauk M, Stöckmann F (1983) Liver disease and glucose homoiostasis. In: Blanchi L, Gerok W, Landmann L, Sickonger K, Stalder GA (eds) Liver in metabolic disease. MTP, Boston, pp 221–234

    Google Scholar 

  22. DeFronzo RA, Bonadonna RC, Ferrannini E (1992) Patho genesis of NIDDM. A balanced overview. Diabetes Care 15:318–368

    CAS  PubMed  Google Scholar 

  23. DeLissio M, Goodyear LJ, Fuller S, Krawitt EL, Devlin JT (1991) Effects of treadmill exercise on fuel metabolism in hepatic cirrhosis. J Appl Physiol 70:210–215

    Google Scholar 

  24. Elia M (1991) The inter-organ flux of substrates in fed and fasted man, as indicated by arterio-venous balance studies. Nutr Res Rev 4:3–31

    Google Scholar 

  25. Erikson J, Fransilla-Kalunki A, Ekstrand A, Salorante C, Widen E, Schalin C, DeGroop L (1989) Early metabolic defects in persons at increased risk for non-insulin dependent diabetes mellitus. N Engl J Med 321:333–343

    Google Scholar 

  26. Fan ST, Wong J (1992) Metabolic clearance of a fat emulsion containing medium-chain triglycerides in cirrhotic patients. J Parent Enter Nutr 16:279–283

    Google Scholar 

  27. Farrer M, Fulcher GR, Johnson AJ, Record CO, Alberti KGMM (1992) Effect of acute inhibition of lipolysis on operation of the glucose-fatty acid cycle in hepatic cirrhosis. Metabolism 41:465–470

    Google Scholar 

  28. Forbes A, Wicks C, Marshall W, Johnsson P, Forsey P, Williams R (1987) Nutritional support in hepatic failure: the safety of lipid solutions. Gut 28:1347–1349

    Google Scholar 

  29. Fulcher GR, Walker M, Catalano C, Farrer M, Alberti KGMM (1992) Acute metabolic and hormonal responses to the inhibition of lipolysis in non-obese patients with non-insulin dependent (type 2) diabetes mellitus: effect of acipimox. Clin Sci 82:565–571

    Google Scholar 

  30. Gottesman I, Mandarino L, Gerich J (1984) Use of glucose uptake and glucose clearance for the evaluation of insulin action in vivo. Diabetes 33:184–191

    Google Scholar 

  31. Groszman RJ (1993) Hyperdynamic state in chronic liver diseases. J Hepatol 17 [Suppl 2]:S38-S40

    Google Scholar 

  32. Henley KS, Laughrey EG, Clancy PE (1974) Gluconeogenesis in the fatty and cirrhotic liver of the rat. The effect of oleate and ethanol. In: Lundquist F, Tygstrup N (eds) Regulation of hepatic metabolism. Munsgaard, Copenhagen, pp 401–413

    Google Scholar 

  33. Heymsfield SB, Waki M, Renius J (1990) Are patients with chronic liver disease hypermetabolic? Hepatology 11:502–505

    Google Scholar 

  34. Ito K, Ramirez-Schon G, Shah PM, Del Guercio LRM (1988) Functioning hepatic cell mass and the hyperdynamic state in cirrhosis. Surg Gynecol Obstet 167:180–186

    Google Scholar 

  35. Jhangiani SS, Agarwal N, Holmes R, Cayton CG, Pitchumomi CS (1986) Energy expenditure in chronic alcoholics with and without liver disease. Am J Clin Nutr 44:323–329

    Google Scholar 

  36. Johnston DG, Alberti KGMM, Wright R, Blain PG# (1982) Glycerol clearance clearance in alcoholic liver disease. Gut 23:257–264

    Google Scholar 

  37. Keller U, Sonnenberg GE, Burckhardt D, Perruchoud V (1982) Evidence for an augmented glucose dependence of hepatic glucose production in cirrhosis of the liver. J Clin Endocrin Metab 54:961–968

    Google Scholar 

  38. Kemmer FW, Berger M (1992) Exercise. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International textbook of diabetes mellitus. Wiley, New York, pp 725–744

    Google Scholar 

  39. Klein S, Sakurai Y, Romjin JA, Caroll RM (1993) Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men. Am J Physiol 265:E801-E806

    Google Scholar 

  40. Kruszynska Y, Williams N, Perry M, Home P (1988) The relationship between insulin sensitivity and skeletal muscle enzyme activities in liver cirrhosis. Hepatology 3:1615–1619

    Google Scholar 

  41. Kruszynska Y, McIntyre N (1991) Carbohydrate metabolism. In: McIntyre N, Benhamou J-P, Bircher J, Rizzetto M, Rodes J (eds) Oxford textbook of clinical hepatology, vol 2. Oxford University Press, Oxford, pp 129–143

    Google Scholar 

  42. Kruszynska YT, Home PD, McIntyre N (1991) Relationship between insulin sensitivity, insulin secretion and glucose tolerance in cirrhosis. Hepatology 14:103–111

    Google Scholar 

  43. Kruszynska YT, Meyer-Alber A, Darakhshan F, Home PD, McIntyre N. (1993) Metabolic handling of orally administered glucose in cirrhosis. J Clin Investig 91:1057–1066

    Google Scholar 

  44. Kruszynska YT, Harry DS, Bergman RN, McIntyre N (1993) Insulin sensitivity, insulin secretion, and glucose effectiveness in diabetic and non-diabetic patients. Diabetologia 36:121–128

    Google Scholar 

  45. Lautz HU, Selberg O, Körber J, Bürger M, Müller MJ (1992) Protein-calorie malnutrition in liver cirrhosis. Clin Investig 70:478–486

    Google Scholar 

  46. Letiexha MR, Scheen AJ, Gerard PL, Bastens BH, Pirotte J, Belaiche J, Lefebvre PJ (1993) Insulin secretion, clearance and action on glucose metabolism in cirrhotic patients. J Clin Endocrin Metab 77:1263–1268

    Google Scholar 

  47. Mansell PI, MacDonald IA (1990) The effect of starvation on insulin-induced glucose disposal and thermogenesis in man. Metabolism 39:502–510

    Google Scholar 

  48. Marchesini G, Bianchi GP, Zoli M, Checcia GA (1987) Glucose homoiostasis in cirrhosis. In: Tygstrup N, Orlandi F (eds) Cirrhosis of the liver: methods and fields of research. Amsterdam, Elsevier, pp165–176

    Google Scholar 

  49. Marchesini G, Pacini G, Bianchi G, Patrono D, Cobelli C (1990) Glucose disposal, β-cell secretion, and hepatic insulin extraction in cirrhosis: a minimal model assessment. Gastroenterology 99:1715–1722

    Google Scholar 

  50. Marshall S, Garvey WT, Traxinger RR (1991) New insights into the metabolic regulation of insulin action and insulin resistance: role of glucose and amino acids. FASEB J 5:3031–3036

    Google Scholar 

  51. Martens E, Zick R, Mitzkat HJ, von zur Mühlen A, Müller MJ (1988) Assessment of insulin action in man: role of hyperglycemia. Acta Endocrinol 119:213–222

    Google Scholar 

  52. Merli M, Eriksson LS, Hagenfeldt I, Wahren J (1986) Splanchnic and leg exchange of free fatty acids in patients with liver cirrhosis. J Hepatol 3:348–355

    Google Scholar 

  53. Merli M, Riggio O, Romiti A, Ariosto F, Mango L, Pinto G, Savioli M, Capocaccia L (1990) Basal energy production rate and substrate use in stable cirrhotic patients. Hepatology 12:106–112

    Google Scholar 

  54. Meyer-Alber A, Hartmann H, Stümpel F, Creutzfeld W (1992) Mechanisms of insulin resistance in CCl4-induced cirrhosis of rats. Gastroenterology 102:223–229

    Google Scholar 

  55. Miller JP (1990) Dyslipoproteinaemia of liver disease. Ballieres Clin Endocrinol Metab 4:807–832

    Google Scholar 

  56. Möller P, Bergström J, Fürst P, Hellström U (1984) Muscle biopsies in patients with moderate liver cirrhosis with special referencce to energy rich phsphates and electrolytes. Scand J Gastroenterol 19:267–272

    Google Scholar 

  57. Morrison WL, Bouchier IAD, Gibson JNA, Rennie MJ (1990) Skeletal muscle and whole body protein turnover in cirrhosis. Clin Nutr 78:613–619

    Google Scholar 

  58. Mullen KD, Denne SC, McCullough AJ, Savin SM, Bruno Tavill AS, Kalhan SC (1986) Leucine metabolism in stable cirrhosis. Hepatology 6:622–630

    Google Scholar 

  59. Müller MJ, Burger AG, Ferrannini E, Jequier E, Acheson KJ (1989) Glucoregulatory function of thyroid hormones: role of pancreatic hormones. Am J Physiology 256:E101-E110

    Google Scholar 

  60. Müller MJ, Lautz HU, Canzler H, Schmidt FW (1989) Hormonelle und metabolische Faktoren in der Regulation des Energieverbrauches bei Leberzirrhotikern. In: Wolfram G, Eckart J, Adolph M (eds) Beiträge zur Infusionstherapie, künstliche Ernährung. Karger, Basel, pp 350–358

    Google Scholar 

  61. Müller MJ, Lantz HU, Selberg O, Willmann O, Rieger A, Fenk A, Canzler H, Schmidt FW (1990) Defective glucose storage as a cause of insulin resistance in liver cirrhosis. Clin Nutr 90:929 (abstract)

    Google Scholar 

  62. Müller MJ, Fenk A, Lantz HU, Selberg O, Canzler H, Balks HJ, von zur Mühlen A, Schmidt E, Schmidt FW (1991) Energy expenditure and substrate metabolism in ethanol-induced liver cirrhosis. Am J Physiol 260:E338-E344

    Google Scholar 

  63. Müller MJ, Lautz HU, Selberg O, Canzler H, Schmidt FW (1991) Ernährung bei chronischen Lebererkrankheiten. Dtsch Med Wochenschr 116:909–916

    Google Scholar 

  64. Müller MJ, Lautz HU, Plogmann B, Bürger M, Körber J, Schmidt FW (1992) Energy expenditure and substrate oxidation in patients with cirrhosis: the impact of cause, clinical staging and nutritional state. Hepatology 15:782–794

    Google Scholar 

  65. Müller MJ, Rieger A, Willmann O, Lantz HU, Balks HJ, von zur Mühlen A, Canzler H, Schmidt FW (1992) Metabolic responses to lipid infusions in patients with liver cirrhosis. Clin Nutr 11:193–206

    Google Scholar 

  66. Müller MJ, Willmann O, Fenk A, Rieger A, Selberg O, Canzler H, von zur Mühlen A, Schmidt FW (1992) Resting energy expenditure and the thermic effect of adrenaline in patients with liver cirrhosis Clin Sci 83:191–198

    Google Scholar 

  67. Müller MJ, Willmann O, Rieger A, Fenk A, Selberg O, Lantz HU, Bürger M, Balks HJ, von zur Mühlen A, Schmidt FW (1992) Mechanism of insulin resistance associated with liver cirrhosis. Gastroenterology 102:2033–2041

    Google Scholar 

  68. Müller MJ, Böttcher J, Selberg O (1993) Energy expenditure and substrate metabolism in liver cirrhosis. Intern J Obesity 17 [Suppl 3]:5102–5106

    Google Scholar 

  69. Müller MJ, Böker KHW, Selberg O (1994) Are patients with liver cirrhosis hypermetabolic? Clin Nutriton 13:131–144

    Google Scholar 

  70. Niblock A, Lindsay Y, Weryk B, Watt PW, Rennie MJ (1989) Glutamine stimulates glycogen synthesis in skeletal muscle. Clin Nutr 8 [Suppl]:97 (abstract)

    Google Scholar 

  71. Nosadini R, Avogaro A, Mollo F, Marescotti C, Tiengo A, Duner E, Merkel C, Gatta A, Zuin R, De Kreutzenberg S, Trevisan R, Crepaldi C (1984) Carbohydrate and lipid metabolism in cirrhosis. Evidence that hepatic uptake of gluconeogenic precursors and of free fatty acids depends on effective hepatic flow. J Clin Endocrinol Metab 58:1125–1132

    Google Scholar 

  72. Nygren A, Bulow G, Sundblad L, Thunberg E, Wiechel KL (1988) The effect of glipizide on extraction of insulin by the human cirrhotic and noncirrhotic liver. Metabolism 37:810–814

    Google Scholar 

  73. Oehler G (1985) Glukosetoleranzstörungen bei Leberkrankheiten. Akt Ernährungsmedizin 10:115–119

    Google Scholar 

  74. Owen OE, Reichle FA, Mozzoli MA, Kreulen T, Patel MS, Elfenbein IB, Golsorkhi M, Chang KHY, Rao NS, Sue HS, Boden G (1981) Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis. J Clin Invest 68:240–252

    Google Scholar 

  75. Owen OE, Trapp VE, Reichard GA, Mozzoli MA, Montezuma J, Paul P, Scutches CL, Boden G (1983) Nature and quantity of fuels consumed in patients with alcoholic cirrhosis. J Clin Invest 72:1821–1832

    Google Scholar 

  76. Owen OE, Mozzoli MA, Reichle FA, Kreulen TH, Owen RS, Boden G, Polansky M (1985) Hepatic and renal metabolism before and after portasystemic shunts in patients with cirrhosis. J Clin Invest 76:1209–1217

    Google Scholar 

  77. Owen OE (1988) Regulation of energy and metabolism. In: Kinney JM, Jeejeebhoy KN, Hill GL, Owen OE (eds) Nutrition and metabolism in patient care. Saunders, Philadelphia, pp 35–59

    Google Scholar 

  78. Petrides AS (1992) Einfluβ von Glukagon auf die hepatische Glukoseproduktbei Leberzirrhose. Z Gastroenterol 30:667

    Google Scholar 

  79. Petrides AS, DeFronzo RA (1989) Glucose metabolism in cirrhosis. A review with some perspectives for the future. Diab Metab Rev 5:691–709

    Google Scholar 

  80. Petrides AS, Groop LC, Riely CA, DeFronzo RA (1991) Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis. J Clin Invest 88:561–570

    Google Scholar 

  81. Petrides AS, Luzi L, Reuben A, Riely C, DeFronzo RA (1991) Effect of insulin and plasma amino acids concentrations and on leucine metabolism in cirrhosis. Hepatology 14:432–441

    Google Scholar 

  82. Petrides AS, Riely C, DeFronzo RA (1991) Insulin resistance in noncirrhotic idiopathic portal hypertension. Gastroenterology 100:245–251

    Google Scholar 

  83. Petrides AS, Schulze-Berg D, Vogt C, Matthews DE, Strohmeyer G (1993) Glucose resistance contributes to diabetes mellitus in cirrhosis. Hepatology 18:284–291

    Google Scholar 

  84. Petrides AS, Vogt C, Schulze-Berge D, Mathews D, Strohmeyer G (1994) Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. Hepatology 19:616–627

    Google Scholar 

  85. Pierrugues R, Michel H (1989) Resting energy expenditure (REE) in patients with alcoholic cirrhosis (ALL): relationship with malnutrition and liver failure. Clin Nutr 8:24

    Google Scholar 

  86. Pirlich M, Bürger M, Lautz HU, Balks H-J, von zur Mühlen A, Schmidt FW, Müller MJ (1991) Gestörte Glukosetoleranz bei Patienten mit Leberzirrhose. Infusionstherapie 18:56 (abstract)

    Google Scholar 

  87. Plauth M, Egberts E-H, Abele R, Muller PH, Fürst P (1990) Characteristic pattern of free amino acids in plasma and skeletal muscle in stable hepatic cirrhosis. Hepatogastroenterology 37:135–139

    Google Scholar 

  88. Quarfordt SH, DeFaria E, Landis EA, Bollinger RR, Yamaguchi Y (1991) Transport of free fatty acid and triglyceride in anhepatic rats. Hepatology 14:911–919

    Google Scholar 

  89. Romjin JA, Endert E, Sauerwein HP (1991) Glucose and fat metabolism during short-term starvation in cirrhosis. Gastroenterology 100:731–737

    Google Scholar 

  90. Roth E, Funovics I, Karner J, Mühlbacher F, Rauhs R, Steininger R, Sporn P, Kleinberger G (1984) Muscle amino acid levels in patients with liver diseases. In: Kleinberger G, Ferency P, Riederer P, Thaler H (eds) Advances in hepatic encephalopathy and urea cycle disease. Basel, Karger, pp 528–537

    Google Scholar 

  91. Schneeweiss B, Graninger W, Ferenci P, Eichinger S, Grimm G, Schneider B, Laggner AN, Lenz K, Kleinberger G (1990) Energy metabolism in patients with acute and chronic liver disease. Hepatology 11:387–393

    Google Scholar 

  92. Schneeweiss B, Pammer J, Ratheiser K, Schneider B, Madl C, Kramer L, Kranz A, Ferenci P, Druml W, Grimm G, Lenz K, Gangl A (1993) Energy metabolism in acute hepatic failure. Gastroenterology 105:1515–1521

    Google Scholar 

  93. Seidel D (1987) Lipoproteins in liver disease. J Clin Biochem 25:541–555

    Google Scholar 

  94. Selberg O, Radoch E, Walter GF, Schwarze M, Müller MJ (1992) Muscle glycogen content in patients with liver cirrhosis. Clin Nutr 11 [Suppl]:6 (abstract)

    Google Scholar 

  95. Selberg O, Burchert W, vd Hoff J, Meyer G, Hundeshagen H, Radoch E, Balks HJ, Müller MJ (1993) Insulin resistance in liver cirrhosis: a pet scan analysis of skeletal muscle glucose metabolism. J Clin Invest 91:1897–1902

    Google Scholar 

  96. Selberg O, Burchert W, vd Hoff J, Meyer GJ, Müller MJ (1993) A PET scan analysis of skeletal muscle blood flow changes during moderate hyperinsulinemia. Clin Nutr 12 [Suppl 2]:14 (abstract)

    Google Scholar 

  97. Selberg O, Radock E, Walter GF, Schwarze M, Müller MJ (1994) Muscle glycogen content in patients with cirrhosis. Hepatology 19 (in press)

  98. Shanbhogue RLK, Bistrian BR, Jenkins RL, Jones C, Benotti P, Blackburn GL (1987) Resting energy expenditure in patients with end stage liver disease and normal population. J Parenter Enter Nutr 11:305–308

    Google Scholar 

  99. Sherwin RS, Fisher M, Bessoff J, Snyder N, Hendler R, Conn M, Felig P (1978) Hyperglucagonemia in cirrhosis: altered secretion and sensitivity to glucagon. Gastroenterology 74:1224–1228

    Google Scholar 

  100. Shmueli E, Record CO, Alberti KGMM (1992) Liver disease, carbohydrate metabolism and diabetes. Ballieres Clin Endocrinol Metab 6:719–743

    Google Scholar 

  101. Shmueli E, Walker M, Alberti G, Record CO (1993) Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis. Hepatology 18:86–95

    Google Scholar 

  102. Shmueli E, Stewart M, Alberti KGMM, Record CO (1994) Growth hormone, insulin-like growth factor 1 and insulin resistance in cirrhosis. Hepatology 19:322–328

    Google Scholar 

  103. Shaw JHF, Wolfe RR (1989) An integrated analysis of glucose, fat and protein metabolism in severely traumatized patients. Studies in the basal state and the response to total parenteral nutrition. Ann Surg 209:63–71

    Google Scholar 

  104. Silva G, Gomis R, Bosch J, Casamitjana R, Mastai R, Navasa M, Rivera F, Rodes J (1988) Hyperglucagonism and glucagon resistance in cirrhosis. Paradoxical effect of propranolol on plasma glucagon levels. J Hepatol 6:325–333

    Google Scholar 

  105. Tettenborn M, Dettmer A, Fichter J, Wagner TOF, Müller MJ (1992) Energieverbrauch und Substratstoffwechsel unter körperlicher Belastung bei Patienten mit Leberzirrhose. Z Gastroenterol 30:109–110 (abstract)

    Google Scholar 

  106. Thörne A, Johannson U, Wahren J, Eriksson S (1992) Thermogenic response to intravenous nutrition in patients with cirrhosis. J Hepatol 16:145–152

    Google Scholar 

  107. Tschepe A, Saeger HD, Belz J, Gladisch R, Holm E (1986) Metabolic effects of various parenteral nutrition regimens (lipid systems) in patients with liver cirrhosis. In: Holm E, Kasper H (eds) Metabolism and nutrition in liver disease. MTP, Lancaster, pp 313–321

    Google Scholar 

  108. Vaag A, Skött P, Damsbo P, Gall A-A, Richter EA, Beck-Nielsen H (1991) Effect of the nicotinic acid analogue acipimox on whole body and skeletal muscle glucose metabolism in patients with non-insulin dependent diabetes mellitus. J Clin Invest 88:1282–1290

    Google Scholar 

  109. Vilstrup H, Iversen J, Tygstrup N (1986) Glucoregulation in acute liver failure. Eur J Clin Invest 16:193–197

    Google Scholar 

  110. Virkamäki A, Puhakainen I, Koivisto VA, Vuorinen-Markkola H, Yki-Järvinnen H (1992) Mechanisms of hepatic and peripheral insulin resistance during acute infections in humans. J Clin Endocrinol Metab 74:673–679

    Google Scholar 

  111. Wasserman JR, Cherrington AD (1991) Hepatic fuel metabolism during muscular work: role and regulation. Am J Physiol 260:E811-E824

    Google Scholar 

  112. Woll PJ, Record CO (1979) Lactate elimination in man: effects of lactate concentration and hepatic dysfunction. Europ J Clin Invest 9:397–404

    Google Scholar 

  113. Yki-Järvinnen H (1994) Pathogenesis of non-insulin-dependent diabetes mellitus. Lancet 343:91–95

    Google Scholar 

  114. Yki-Järvinnen H, Young AA, Lamkin C, Foley JE (1987) Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest 79:1713–1719

    Google Scholar 

  115. Zoli M, Bianchi GP, Marzocchi A, Marrozzini C, Capelli M, Mazzioli L, Chechia A, Cazzarani S, Dondi L, Marchesini G (1984) Splanchnic, peripheral and renal exchange of amino acids in cirrhotic patients with portal hypertension. In: Kleinberger G, Ferency P, Riederer P, Thaler H (eds) Advances in hepatic encephalopathy and urea cycle disease. Basel, Karger, pp 538–544

    Google Scholar 

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  1. M. J. Müller

    Present address: Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität, Düsternbrooker weg 17, D-24105, Kiel, Germany

Authors and Affiliations

  1. Abteilung Ernährungsmedizin, Max von Pettenkofer Institut, Thielallee 88-92, D-14195, Berlin, Germany

    M. J. Müller

  2. Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, D-30625, Hannover, Germany

    K. H. W. Böker

  3. Abteilung Klinische Chemie II, Medizinische Hochschule Hannover, Podbielskistrasse 380, D-30659, Hannover, Germany

    O. Selberg

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Müller, M.J., Böker, K.H.W. & Selberg, O. Metabolism of energy-yielding substrates in patients with liver cirrhosis. Clin Investig 72, 568–579 (1994). https://doi.org/10.1007/BF00227447

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