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On the mechanism of the post-activation depression of the H-reflex in human subjects

Experimental Brain Research volume 108, pages 450–462 (1996)Cite this article

Abstract

It was demonstrated that the soleus H-reflex was depressed for more than 10 s following a preceding passive dorsiflexion of the ankle joint. This depression was caused by activation of large-diameter afferents with receptors located in the leg muscles, as an ischaemic block of large-diameter fibres just below the knee joint abolished the depression, whereas a similar block just proximal to the ankle joint was ineffective. The depression of the H-reflex was not caused by changes in motoneuronal excitability, as motor-evoked potentials by magnetic brain stimulation were not depressed by the same passive dorsiflexion. Therefore it was concluded that the long-lasting depression is due to mechanisms acting at presynaptic level. The transmission of the monosynaptic Ia excitation from the femoral nerve to soleus motoneurones was not depressed by the ankle dorsiflexion. The depression thus seems to be confined to those afferents that were activated by the conditioning dorsiflexion. In parallel experiments on decerebrate cats, more invasive methods have complemented the indirect techniques used in the experiments on human subjects. A similar long-lasting depression of triceps surae monosynaptic reflexes was evoked by a preceding conditioning stimulation of the triceps surae Ia afferents. This depression was accompanied by a reduction of the monosynaptic Ia excitatory postsynaptic potential recorded intracellularly in triceps surae motoneurones, but not by changes in the input resistance or membrane potential in the motoneurones. Stimulation of separate branches within the triceps surae nerve demonstrated that the depression is confined to those afferents that were activated by the conditioning stimulus. This long-lasting depression was not accompanied by a dorsal root potential. It is concluded that the long-lasting depression is probably caused by a presynaptic effect, but different from the “classical” GABAergic presynaptic inhibition which is widely distributed among afferent fibres and accompanied by dorsal root potentials. It is more probably related to the phenomenon of a reduced transmitter release from previously activated fibres, i.e. a homosynaptic post-activation depression. The consequences of this post-activation depression for the interpretation of results on spinal mechanisms during voluntary movements in man are discussed.

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Authors and Affiliations

  1. Division of Neurophysiology, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark

    H. Hultborn, J. Nielsen & M. Ballegaard

  2. Physiologisches Institut, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24118, Kiel, Germany

    M. Illert, A. Paul & H. Wiese

Authors
  1. H. Hultborn
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  2. M. Illert
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  3. J. Nielsen
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  4. A. Paul
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  5. M. Ballegaard
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  6. H. Wiese
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Hultborn, H., Illert, M., Nielsen, J. et al. On the mechanism of the post-activation depression of the H-reflex in human subjects. Exp Brain Res 108, 450–462 (1996). https://doi.org/10.1007/BF00227268

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  • DOI: https://doi.org/10.1007/BF00227268

Key words

  • Spinal cord
  • H-reflexes
  • Ia afferents
  • Reflex pathways
  • Homosynaptic depression
  • Human
  • Cat