Skip to main content
Log in

Statistical data support prediction of death within 6 months on low levels of coenzyme Q10 and other entities

  • Conference on Coenzyme Q
  • Published:
The clinical investigator Aims and scope Submit manuscript

Summary

Ninety-four consecutive hospital patients aged over 50 years were included in a cross-sectional study. Serum samples were analyzed for coenzyme Q10, α-tocopherol, and free cholesterol levels. Patients who died within a follow-up period of 6 months or had congestive heart failure or severe myalgia, and/or received cytostatic or lipid-lowering drug therapy showed significantly lower free cholesterol-related coenzyme Q10 values. Prospective controlled clinical trials will determine whether coenzyme Q10 has a potential to protect patients from such complications and become a useful therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

BHb:

blood hemoglobin

BSR:

blood sedimentation rate 1 h

BMI:

body mass index

SCr:

serum creatinine

SVE:

serum a-tocopherol, or vitamin E

SFC:

serum free cholesterol

SQ10 :

serum coenzyme Q10

References

  1. Anonymous (1992) Simvastatin. Lancet 339:547

  2. Crane F (1986) Physiological coenzyme Q function and pharmacological reactions. In: Folkers K, Yamamura Y (eds) Biomedical and clinical aspects of coenzyme Q, vol 5. Elsevier, Amsterdam, pp 3–14

    Google Scholar 

  3. Cross C (1987) Oxygen radicals and human disease. Ann Intern Med 107:526–545

    Google Scholar 

  4. Doroshow J (1991) Doxorubicin-induced cardiac toxicity. N Engl J Med 324:843–845

    Google Scholar 

  5. Edlund P-O (1988) Determination of coenzyme Q-10, alphatocopherol and cholesterol in biological samples by coupled-column liquid chromatography with coulometric and ultraviolet detection. J Chromatogr 425:87–97

    Google Scholar 

  6. Esterbauer H, Jiirgens G, Quehenberger O, Koller E (1987) Antioxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res 28:495–509

    Google Scholar 

  7. Esterbauer H, Rotheneder M, Striegl G (1989) Vitamin E and other lipophilic antioxidants protect LDL against oxidation. Fat Sci Technol 91:316–324

    Google Scholar 

  8. Esterbauer H, Striegl G, Puhl H, Oberreither S, Rotheneder M, Jürgens G (1989) The role of vitamin E and carotenoids in preventing oxidation of low density lipoproteins. Ann NY Acad Sci 570:254–267

    Google Scholar 

  9. Gey F, Puska P, Jordan P, Moser U (1991) Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 53:326S-3345

    Google Scholar 

  10. Ghirlanda G, Lippa S, Oradei A, Bianchi M, Caputo S, Magnani P, Manto A, Greco A, Littarru G (1991) Effect of simvastatin on plasma ubiquinone (CoQ10) levels. In: Folkers K, Littarru G, Yamagami T (eds) Biomedical and clinical aspects of coenzyme Q, vol 6. Elsevier, Amsterdam, pp 431–436

    Google Scholar 

  11. Greenberg S, Frishman W (1990) Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 30:596–608

    Google Scholar 

  12. Hanaki Y, Sugiyama S, Ozawa T, Ohno M (1991) Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor. N Engl J Med 325:814–815

    Google Scholar 

  13. Jameson S (1991) Coenzyme Q10, alpha-tocopherol, and free cholesterol levels in sera from diabetic patients. In: Folkers K, Littarru G, Yamagami T (eds) Biomedical and clinical aspects of coenzyme Q, vol 6. Elsevier, Amsterdam, pp 151–158

    Google Scholar 

  14. Johansen K. Theorell H, Karlsson J, Diamant B, Folkers K (1991) Coenzyme Q10, alpha-tocopherol and free cholesterol in HDL and LDL fractions. Ann Med 23:649–656

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jameson, S. Statistical data support prediction of death within 6 months on low levels of coenzyme Q10 and other entities. Clin Investig 71 (Suppl 8), S137–S139 (1993). https://doi.org/10.1007/BF00226855

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00226855

Key words

Navigation