Summary
The neuroepithelial bodies (NEB's) of the lung of 29-day-old fetuses and 1-day-old rabbits, under the conditions of this study, neither take up 3H-thymidine nor undergo mitosis. Also the NEB's are not derived at these times from proliferations of other kinds of epithelial cells in the intrapulmonary airways. It is, therefore, suggested that the difference in numbers of NEB's previously observed by us, between the 29-day fetus and the 1-day-old rabbit, is due either to regranulation or acquisition of argyrophilic material by the NEB's or differentiation of other epithelial types. It is concluded that the NEB's are composed of well differentiated cells, which have a greatly reduced capacity to undergo mitosis.
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Andrew, A.: An experimental investigation into the possible neural crest origin of the pancreatic APUD (islet) cells. J. Embryol. exp. Morph. 35, 577–593 (1976)
Bensch, K.G., Corrin, B., Pariente, R., Spencer, H.: Oat cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid. Cancer (Philad.) 22, 1163–1172 (1968)
Cameron, I.L.: Is the duration of DNA synthesis in somatic cells of mammals and birds a constant? J. Cell Biol. 18, 31–40 (1963)
Cameron, I.L., Greulich, R.C.: Evidence for an essentially constant duration of DNA synthesis in renewing epithelia of the adult mouse! J. Cell Biol. 18, 31–40 (1963)
Csaba, G., Kovacs, P.: Selective 5-HT uptake by epithelial cells of the rat lung. Acta morph. Acad. hung. 23, 235–238 (1975)
Cutz, E., Chan, W., Wong, V., Conen, P.E.: Endocrine cells in rat fetal lungs. Ultrastructural and histochemical study. Lab. Invest. 30, 458–464 (1974)
Cutz, E., Chan, W., Wong, V., Conen, P.E.: Ultrastructure and fluorescence histochemistry of endocrine (APUD-Type) cells in tracheal mucosa of human and various animal species. Cell Tiss. Res. 158, 425–437 (1975)
Defendi, V., Manson, L.A.: Analysis of life cycles in mammalian cells, Nature (Lond.) 198, 359–360 (1963)
Hage, E.: Endocrine cells in the bronchial mucosa of human foetuses. Acta path, microbiol. scand., Sect. A 80, 225–234 (1972)
Hattori, S., Matsuda, M., Tateishi, R., Mishihara, M., Horai, T.: Oat cell carcinoma of the lung. Clinical and morphological studies in relation to its histogenesis. Cancer (Philad.) 30, 1014–1024 (1972)
Hernandez-Vasquez, A., Will, J.A., Quay, W.B.: Quantitative characteristics of the Feyrter (APUD) cells of the neonatal rabbit lung in normoxic and chronic hypoxia. Thorax, in Press (1977a)
Hernandez-Vasquez, A., Will, J.A., Quay, W.B.: Quantitative characteristics of the Feyrter cells and neuroepithelial bodies of the fetal rabbit lungs in normoxia and chronic hypoxia. In preparation (1977b)
Janners, M.Y., Searls, R.L.: Changes in rate of cellular proliferation during the differentiation of cartilage and muscle in the mesenchyme of the embryonic chick wing. Develop. Biol. 23, 136–165 (1970)
Kauffman, S.L.: Kinetics of pulmonary epithelial proliferation during prenatal growth of the mouse lung. Anat. Rec. 183, 3, 393–404 (1975)
Lauweryns, J.M., Cokelaere, M.: Hypoxia sensitive neuro-epithelial bodies. Intrapulmonary secretory neuroreceptors, modulated by the CNS. Z. Zellforsch. 145, 521–540 (1973a)
Lauweryns, J.M., Cokelaere, M., Theunynck, P.: Serotonin producing neuroepithelial bodies in rabbit respiratory mucosa. Science 180, 410–413 (1973b)
Lauwreyns, J.M., Cokelaere, M., Theunynck, P., Deleersnyder, M.: Neuroepithelial bodies in mamalian respiratory mucosa. Light optical, histochemical and ultrastructural studies. Chest 65, 225–295 (1974)
Moosavi, H., Smith, P., Heath, D.: The Feyrter cell in hypoxia. Thorax 28, 729–741 (1973)
Pearse, A.G.E.: The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J. Histochem. 17, 303–313 (1969)
Pearse, A.G.E., Polak, J.M.: Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas. Gut 12, 783–788 (1971)
Pearse, A.G.E., Polak, J.M., Heath, C.M.: Development differentiation and derivation of the endocrine polypeptide cells and their distinction by sequential immunofluorescence. Folia Histochem. Cytochem. 10, 115–120 (1972)
Pictet, R.L., Rall, L.B., Phelps, P., Rutter, W.J.: The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells. Science 191, 191–192 (1976)
Polak, J.M., Rost, F.W.D., Pearse, A.G.E.: Fluorogenic amine tracing of neural crest derivatives forming the adrenal medulla. Gen. comp. Endocr. 8, 115–128 (1971)
Soutar, C.A.: Distribution of plasma cells and other cells containing immunoglobulin in the respiratory tract of normal man and class of immunoglobulin contained therein. Thorax 31, 158–166 (1976)
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The authors wish to thank Mrs. Barbara Freedman and Mrs. Janice Lokken for their valuable technical assistance and Ms. Suzanne Macho for preparation of the manuscript. The work was supported by the College of Agricultural and Life Sciences, University of Wisconsin-Madison, and by Grant 1036 from the Tobacco Research Council
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Hernandez-Vasquez, A., Will, J.A. & Quay, W.B. A radioautographic study of the neuroepithelial bodies of the lungs in fetal and neonatal rabbits. Cell Tissue Res. 186, 203–207 (1978). https://doi.org/10.1007/BF00225531
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DOI: https://doi.org/10.1007/BF00225531