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Stimulation of insulin release by L-glutamine

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Summary

Under normal environmental conditions, L-glutamine is well oxidized but fails to stimulate insulin release in rat pancreatic islets. However, a marked stimulation of insulin release by L-glutamine, without alteration in its oxidation rate, occurs when the intracellular pH of the islet cells is decreased and/or when theophylline is added to the incubation medium.

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Authors and Affiliations

  1. Laboratory of Experimental Medicine, Brussels University, Brussels, Belgium

    Abdullah Sener & Willy J. Malaisse

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  1. Abdullah Sener
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  2. Willy J. Malaisse
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Sener, A., Malaisse, W.J. Stimulation of insulin release by L-glutamine. Mol Cell Biochem 33, 157–159 (1980). https://doi.org/10.1007/BF00225288

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  • DOI: https://doi.org/10.1007/BF00225288

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