Summary
(3H)-Thymidine autoradiography was used to study the DNA synthesis in the stroma and epithelium in the uterus proper and the uterine cervix of neonatal mice treated with oestradiol. It was found that in the epithelium of the uterus proper the DNA synthesis is stimulated between 6 and 12 h after injection of oestradiol and decreases again at 18 h. In the stroma of the uterus proper the DNA synthesis is increased 18 h after oestradiol injection.
In the epithelium and stroma of the uterine cervix the DNA synthesis decreases from 5 h and is strongly depressed 18 h after oestradiol treatment.
Similar content being viewed by others
References
Das, R. M.: The time-course of the mitotic response to oestrogen in the epithelia and stroma of the mouse uterus. J. Endocr. 55, 203–204 (1972)
Eide, A.: The effect of estradiol on the cell kinetics in the uterine and cervical epithelium in neonatal mice. Cell Tissue Kinet. in press (1975)
Forsberg, J.-G.: The effect of estradiol-17 β on the epithelium in the mouse vaginal anlage. Acta anat. (Basel) 63, 71–88 (1966)
Forsberg, J.-G.: An estradiol mitotic rate inhibiting effect in the müllerian epithelium in neonatal mice. J. exp. Zool. 175, 369–374 (1970)
Forsberg, J.-G., Jacobsohn, D., Norgren, A.: Reactions of the vaginal plate and the vaginal epithelium to oestradiol monopropionate given once to 5 or 26-day old rats. Z. Zellforsch. 88, 105–112 (1968)
Kaye, A.M., Sheratzky, D., Lindner, H. R.: Kinetics of DNA synthesis in immature rat uterus: age dependance and estradiol stimulation. Biochim. biophys. Acta (Amst.) 261, 475–486 (1972)
Martin, L., Finn, C.A.: Hormonal regulation of cell division in epithelial and connective tissues of the mouse uterus. J. Endocr. 41, 363–371 (1968)
Martin, L., Finn, C.A.: Oestrogen-gestagen interactions on mitosis in target tissues. In: Basic actions of sex steroids on target organs, p. 172–188. Basel: Karger 1971
Martin, L., Finn, C. A., Trinder, G.: Hypertrophy and hyperplasia in the mouse uterus after oestrogen treatment: an autoradiographic study. J. Endocr. 56, 133–144 (1973a)
Martin, L., Finn, C. A., Trinder, G.: DNA synthesis in the endometrium of progesteronetreated mice. J. Endocr. 56, 303–307 (1973b)
Mori, T.: Mitotic activity in uterine and vaginal epithelium following postpuberal estrogen injections in neonatally estrogenized mice. Proc. Japan Acad. 45, 931–936 (1969)
Raynaud, J.-P.: Influence of rat estradiol binding plasma protein (EBP) on uterotrophic activity. Steroids 21, 249–258 (1973)
Smith, J. A., Martin, L., King, R. J. B., Vertes, M.: Effects of oestradiol and progesterone on total and nuclear-protein synthesis in epithelial and stromal tissues of the mouse uterus, and of progesterone on the ability to bind oestradiol-17 β Biochem. J. 119, 773–784 (1970)
Sömjen, D., Kaye, A.M., Lindner, H. R.: Postnatal development of uterine response to estradiol-17 β in the rat. Develop. Biol. 31, 409–412 (1973)
Author information
Authors and Affiliations
Additional information
This work has been supported by grants from the Norwegian Research Council for Science and the Humanities and from the Norwegian Cancer Society (Landsforeningen mot Kreft).
Rights and permissions
About this article
Cite this article
Eide, A. The effect of oestradiol on the DNA synthesis in neonatal mouse uterus and cervix. Cell Tissue Res. 156, 551–555 (1975). https://doi.org/10.1007/BF00225113
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00225113