Skip to main content
SpringerLink
Log in

High density lipoprotein exchange reactions

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

The term human serum high density lipoprotein (HDL) represents a range of lipid-protein complexes which are identified by their density and hence their relative lipid-protein content. Because HDL composition is variable, any proposed mechanisms for lipid and protein exchange must account for this variability.

More importantly, since HDL has been repeatedly shown to be a negative risk factor in atherosclerosis, physical interactions have to be put in a physiological context. In this review, the lipid and protein exchange reactions of HDL with other lipoproteins, phospholipid vesicles, lipid-coated glass beads and isolated cells, will be considered. Particular emphasis will be placed on the role of the two major apoproteins of HDL, namely apo A-I and apo A-II, in these exchange reactions and a model will be presented to explain how these apoproteins might mediate lipid exchange, interconversions of lipoprotein particles, and the egress and excretion of lipid from cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Scanu, A. M., Edelstein, C. and Keim, P., 1975. In: The Plasma Proteins (Putnam, F. W., ed.). Vol. I, pp. 317–491, Academic Press, New York.

  2. Smith, L. C., Pownall, H. S. and Gotto, A. M., 1978. Ann. Rev. Biochem 47: 751–757.

    Google Scholar 

  3. Herbert, P. N., Gotto, A. M. and Frederickson. D. S., 1978. In: The Metabolic Basis of Inherited Disease (Stanbury, J. B., Wijngaarden, J. B. and Fredrickson, D. S., eds.), 4th edition, pp. 544–588, McGraw Hill, New York.

  4. Yatsu, F. and Loeb, J. A., 1982. Clinical Neurosurgery 29: 437–463.

    Google Scholar 

  5. Pattnaik, N. M. and Zilversmit, D. B., 1979. J. Biol. Chem. 254: 2782–2786.

    Google Scholar 

  6. Ihm, J., Ellsworth, J. L., Chataing, B. and Harmony, J. A. K., 1982. J. Biol. Chem. 257: 4818–4827.

    Google Scholar 

  7. Brown, M. and Goldstein, J., 1976. Science 191: 150–154.

    Google Scholar 

  8. Hui, D. Y., Innerarity, T. L. and Mahley, R. W.: 1981. J. Biol. Chem. 256, 5646–5655.

    Google Scholar 

  9. Balasubramaman, S., Goldstein, J. L., Faust, J. R., Brunschede, G. Y. and Brown, M. S., 1977. J. Biol. Chem. 252: 1771–1779.

    Google Scholar 

  10. Verdery, R. B. and Theolis, R., 1982. J. Biol. Chem. 257: 1412–1417.

    Google Scholar 

  11. Scanu, A. M., 1966. J. Lipid Res. 7: 295–306.

    Google Scholar 

  12. Scanu, A. M., Byrne, R. and Milohovivic, M., 1982. Crit. Rev. in Biochem. 13: 109–140.

    Google Scholar 

  13. Weisgraber, K. M. and Mahley, R. W., 1980. J. Lipid Res. 21: 316–325.

    Google Scholar 

  14. Patsch, W., Schofeld, G., Gotto, A. M. and Patsch, J., 1980. J. Biol. Chem. 255: 3178–3185.

    Google Scholar 

  15. Baker, H. N., Delahurty, T., Gotto, A. M. and Jackson, P. L., 1974. Proc. Natl. Acad. Sci. U.S.A. 74: 1043.

    Google Scholar 

  16. Chung, H., Randolph, S., Reardon, I. and Heinrickson, R. L., 1982. J. Biol. Chem. 257: 2961–2967.

    Google Scholar 

  17. Mao, S. J. T., Jackson, R. L., Gotto, A. M. Jr. and Sparrow, J. T., 1981. Biochemistry 20: 1676–1680.

    Google Scholar 

  18. Cheung, M. C. and Albers, J. J., 1979. J. Lipid Res. 20: 200–208.

    Google Scholar 

  19. Kostner, G. M., Patsch, J. R., Sailer, S., Braunsteiner, H. and Holasek, A., 1974. Eur. J. Biochem. 45: 611–621.

    Google Scholar 

  20. Shen, B. W., Scanu, A. M. and Kezdy, F. J., 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 837–841.

    Google Scholar 

  21. Dawson, G., Kruski, A. W. and Scanu, A. M., 1976. J. Lipid Res. 17: 125–131.

    Google Scholar 

  22. Fishman, P. H., Bradley, R. M., Moss, J. and Manganiello, V. C., 1978. J. Lipid Res. 19: 77–81.

    Google Scholar 

  23. Hakomori, S.-I., 1981. Ann. Rev. Biochem 50: 733–764.

    Google Scholar 

  24. Steck, T. L. and Dawson, G., 1974. J. Biol. Chem. 249: 2135–2142.

    Google Scholar 

  25. Kornberg, R. D. and McConnell, H. M., 1971. Biochemistry 10: 1111–1120.

    Google Scholar 

  26. Gatt, S. and Bierman, E. L., 1980. J. Biol. Chem. 255: 3371–3376.

    Google Scholar 

  27. Barenholz, Y. and Thompson, T. E., 1980. Biochim. Biophys. Acta 604: 129–158.

    Google Scholar 

  28. Glomset, J. A., 1968. J. Lipid Res. 9: 155–167.

    Google Scholar 

  29. Fielding, C. J., Schore, V. G. and Fielding, P. E., 1972. Biochem. Biophys. Res. Commun. 46: 1493.

    Google Scholar 

  30. Yokoyama, S., Fukushima, D., Kupferberg, J. P., Kedzy, F. J. and Kaiser, E. T., 1980. J. Biol. Chem. 255: 7333–7339.

    Google Scholar 

  31. Scanu, A. M., Edelstein, C. and Shen, B. W., 1982. In: Molecular Biology of Lipid-Protein Interactions (Just, P. and Griffith, O. H., eds.), pp. 259–316, John Wiley & Sons, New York.

  32. Fielding, C. J. and Havel, R. J., 1972. Arch. Pathol. Lab. Med. 101: 225–229.

    Google Scholar 

  33. Gennis, R. B. and Jonas, B., 1977. Ann Rev. Biophys. Bioeng 6: 195–238.

    Google Scholar 

  34. Morriset, J. D., Jackson, R. L. and Gotto, A. M. Jr., 1977. Biochim. Biophys. Acta 472: 93–133.

    Google Scholar 

  35. Tall, A. R. and Small, D. M., 1980. Adv. Lipid Res. 17: 1–51.

    Google Scholar 

  36. Vitello, L. B. and Scanu, A. M., 1976. J. Biol. Chem. 251: 1131–1136.

    Google Scholar 

  37. Osborne, J. C. Jr. and Brewer, H. B. Jr., 1977. Adv. Protein Chem. 31: 253–337.

    Google Scholar 

  38. Jackson, R. L., Patlers, F., de Haas, G, and Demel, R. A., 1980. Ann. N.Y. Acad. Sci. 348: 76–86.

    Google Scholar 

  39. Shen, B. W. and Scanu, A. M., 1980. Biochemistry 19: 3643–3650.

    Google Scholar 

  40. Shen, B. W. and Scanu, A. M., 1979. Circulation 60: 185.

    Google Scholar 

  41. Jonas, A. and Krajnovich, D. J., 1977. J. Biol. Chem. 252: 2194–2199.

    Google Scholar 

  42. Jonas, A., Krajnovich, D. J. and Patterson, B. W., 1977. J. Biol. Chem. 252: 2200–2205.

    Google Scholar 

  43. Jonas, A., Dregler, S. M. and Kaplan, J. S., 1981. J. Biol. Chem. 256: 2420–2426.

    Google Scholar 

  44. Swaney, J. B., 1980. J. Biol. Chem. 255: 877–881.

    Google Scholar 

  45. Ritter, M. and Scanu, A. M., 1977. J. Biol. Chem. 252: 1208–1216.

    Google Scholar 

  46. Pownall, H. J., Hickson, D. and Gotto, A. M. 1981. J. Biol. Chem. 256: 9819–9854.

    Google Scholar 

  47. Shipley, G. G., Atkinson, D. and Scanu, A. M. 1972. J. Supramol. Struc. 1: 98–104.

    Google Scholar 

  48. Van Turnout, P., Vercaemst, R., Lievens, M. J., Caster, H., Rosseneu, M. and Assmann, G., 1980. Biochim. Biophys. Acta 601: 509–523.

    Google Scholar 

  49. Stoffel, W., Salm, K. and Langer, M., 1978. Hoppe-Zeyler's Z. Physiol. Chem. 359: 1385–1393.

    Google Scholar 

  50. Mantalin, V. W., Massey, J. B., Gotto, A. M. and Pownall, H. J., 1981. J. Biol. Chem. 256: 10815–10819.

    Google Scholar 

  51. Glomset, J. A., 1972. In: Blood Lipids and Lipoproteins: Quantitation Composition and Metabolism (Nelson, E. J., ed.), pp. 745–787, Wiley, New York.

  52. Alaupovic, P., 1981. Canad. J. Biochem. 54: 565–579.

    Google Scholar 

  53. Windmueller, H. G. and Wu, A.-L., 1981. J. Biol. Chem. 256: 3012–3016.

    Google Scholar 

  54. Huttunen, J. K., Ehnholm, C., Kekki, M. and Nikkila, E. A.,. 1976. Clin. Sci. Mol. Med. 50: 249–260.

    Google Scholar 

  55. Eisenberg, S. J., 1980. Ann. N.Y. Acad. Sci. 348: 3046.

    Google Scholar 

  56. Morton, R. E. and Zilversmit, D. B., 1981. J. Biol. Chem. 256: 11992–11995.

    Google Scholar 

  57. Ha, Y. C., Calvert, G. D., McIntosh, G. H. and Barter, P. J., 1981. Metabolism 30: 380–383.

    Google Scholar 

  58. Chajek, T. and Fielding, C. J., 1978. Proc. Natl. Acad. Sci. U.S.A. 75:3445–3449.

    Google Scholar 

  59. Gwynne, J. T. and Hess, B., 1979. Metab. Clin. Exp. 27: 1593–1600.

    Google Scholar 

  60. Chen, Y.-D., Kroemer, F. B. and Reaven, G. M., 1980. J. Biol. Chem. 255: 9162–9167.

    Google Scholar 

  61. Clark, J. T. R., 1981. Canad. J. Biochem. 59: 412–417.

    Google Scholar 

  62. Marcus, D. M. and Cass, L. E., 1969. Science 196: 553–555.

    Google Scholar 

  63. Brewster, M. E., Ihm, J., Brainard, J. R. and Harmony, J. A. K., 1978. Biochim. Biophys. Acta 529: 147–159.

    Google Scholar 

  64. Kwok, B. C. P., Shen, B. W. and Dawson, G., 1981. J. Biol. Chem. 256: 9698–9704.

    Google Scholar 

  65. Shen, B. W., Kwok, B. C. P. and Dawson, G., 1981. J. Biol. Chem. 256: 9705–9710.

    Google Scholar 

  66. Tall, A. R. and Green, P. H. R., 1981. J. Biol. Chem. 256: 2035–2044.

    Google Scholar 

  67. Ohtsuki, M., Edelstein, C., Sogard, M. and Scanu, A. M., 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 5001–5005.

    Google Scholar 

  68. Tall, A. R., Small, D. M., Deckelbaum, R. J. and Shipley, G. G., 1977. J. Biol. Chem. 252: 4701–4711.

    Google Scholar 

  69. Sharom, F. J. and Grant, C. W. M., 1978. Biochim. Biophys. Acta 507: 280–293.

    Google Scholar 

  70. Correa Freire, M. C., Freire, E., Barenholz, Y., Biltonen, R. L. and Thompson, T. E., 1979. Biochemistry 18: 442–445.

    Google Scholar 

  71. Jonas, A., 1979. J. Lipid Res. 20: 817–824.

    Google Scholar 

  72. McLean, L. R. and Phillips, M C, 1981. Biochemistry 20: 2893–2900.

    Google Scholar 

  73. Shen, B. W. and Scanu, A. M., 1980. Biochemistry 19: 3643.

    Google Scholar 

  74. Fielding, P. E. and Fielding, C. J., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 3327–3331.

    Google Scholar 

  75. Tall, A. R. and Small, D. M., 1977. Nature 265: 163–164.

    Google Scholar 

  76. Stein, Y., Glangeaud, M. C., Farnaru, M. and Stein, O., 1975. Biochim. Biophys. Acta 380: 106–118.

    Google Scholar 

  77. Barter, P. J. and Lally, J. I., 1978. Biochim. Biophys. Acta 531: 233–236.

    Google Scholar 

  78. Bloj, B. and Zilversmit, D. B., 1981. J. Biol. Chem. 256: 5988–5993.

    Google Scholar 

  79. Metz, R. J. and Radin, N. S., 1980. J. Biol. Chem. 255: 4463–4467.

    Google Scholar 

  80. Loeb, J. A. and Dawson, G., 1982. J. Biol. Chem. 257: 11982–11987.

    Google Scholar 

  81. Ritter, M. C. and Scanu, A. M., 1980. J. Biol. Chem. 255: 3763–3769.

    Google Scholar 

  82. Kwok, B. C. P., Dawson, G. and Ritter, M. C., 1981. J. Biol. Chem. 256: 92–98.

    Google Scholar 

  83. Dawson, G., Kwok, B. C. P., Nishigaki, M. and Shen, B. W., 1982. In: Gaucher Disease, pp. 253–265. Alan R. Liss, New York.

  84. Rothblatt, G. H., Arbogast, L. Y. and Ray, E. K., 1978. J. Lipid Res. 19: 350–358.

    Google Scholar 

  85. Shepherd, J., Gotto, A. M., Taunton, O. D., Caslake, M. J. and Farish, E., 1977. Biochim. Biophys. Acta 489: 486–501.

    Google Scholar 

  86. Lagocki, P. A. and Scanu, A. M., 1980. J. Biol. Chem. 255: 3701–3706.

    Google Scholar 

  87. Owen, J. S. and McIntyre, N., 1982. TIBS 7: 95–98.

    Google Scholar 

  88. Loeb, J. A. and Dawson, G., unpublished.

  89. Van 't Hooft, M., Van Gent, T. and Van Tol, A., 1981. Biochem. J. 196: 877–885.

    Google Scholar 

  90. Zannis, V. I., Breslow, J. L., SanGiacoma, T. R., Aden, D. P. and Knowles, B. B., 1981. Biochemistry 20: 7089–7096. Received 9 August 1982.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pediatrics and Biochemistry, Joseph P. Kennedy Jr. Mental Retardation Research Center, Pritzker School of Medicine, University of Chicago, 60637, Chicago, IL, USA

    Jeffrey Loeb & Glyn Dawson

Authors
  1. Jeffrey Loeb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Glyn Dawson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Loeb, J., Dawson, G. High density lipoprotein exchange reactions. Mol Cell Biochem 52, 161–176 (1983). https://doi.org/10.1007/BF00224925

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00224925

Keywords

Search

Navigation