Abstract
Long-Term Potentiation (LTP) has three properties: (1) input specificity, (2) cooperativity and (3) associativity. In a previous paper, we proposed an integrated model of the mechanisms of the induction and maintenance of LTP with input specificity. In this paper, a model of the mechanism of cooperative and associative LTP is described. According to computer simulations of the model, its mechanism is based on the spread of synaptic potentials.
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Kitajima, T., Hara, Ki. A model of the mechanism of cooperativity and associativity of long-term potentiation in the Hippocampus: a fundamental mechanism of associative memory and learning. Biol. Cybern. 64, 365–371 (1991). https://doi.org/10.1007/BF00224703
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DOI: https://doi.org/10.1007/BF00224703