Skip to main content
Log in

A new polymorphism in the gene for the dopamine D2 receptor

  • Published:
Human Genetics Aims and scope Submit manuscript

Abstract

A new polymorphism has been identified in the gene for the dopamine D2 receptor. The polymorphism was found by single stranded conformational polymorphism (SSCP) analysis. Sequencing revealed an insertion at a BsoF1 restriction site. This polymorphism in the 3′- untranslated region was found at a frequency of 0.07 in Centre d'Etude du Polymorphisme Humain (CEPH) parents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bolos AM, Dean M, Lucas-Derse S, Ramsburg M, Brown GL, Goldman D (1990) Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. JAMA 264:3156–3160

    Google Scholar 

  • Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JN, White R (1990) Centre d'Etude du Polymorphisme Humain (CEPH): collaborative genetic mapping of the human genome. Genomics 6:676–677

    Google Scholar 

  • Gandleman KY, Harom S, Todd RD, O'Malley KL (1991) Analysis of the structure and expression of the human dopamine D2A receptor gene. J Neurochem 56:1024–1029

    Google Scholar 

  • Grandy DK, Litt M, Allen L, Bunzow JR, Marchionni M, Makam H, Reed L, Magenis RE, Civelli O (1989) The human dopamine D2 receptor gene is located on chromosome 11 at q22–q23 and identifies a Taq1 RFLP. Am J Hum Genet 45:778–785

    Google Scholar 

  • Hayashi K (1991) PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA. PCR Methods Appl 1:34–38

    Google Scholar 

  • Parsian A, Fisher L, O'Malley KL, Todd RD (1991) A new Taq1 RFLP within intron 2 of human dopamine D2 receptor gene (DRD2). Nucleic Acids Res 19:6977

    Google Scholar 

  • Poduslo SE, Dean M, Kolch U, O'Brien SJ (1991) Detecting high-resolution polymorphisms in human coding loci by combining PCR and single strand conformation polymorphism (SSCP) analysis. Am J Hum Genet 49:106–111

    Google Scholar 

  • Sakar G, Kapelner S, Grandy DK, Marchionni M, Civelli O, Sobell J, Heston L, Sommer SS (1991) Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics 11:8–14

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Poduslo, S.E., Schwankhaus, J. A new polymorphism in the gene for the dopamine D2 receptor. Hum Genet 95, 603–604 (1995). https://doi.org/10.1007/BF00223884

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00223884

Keywords

Navigation