Abstract
Number and sex of offspring were determined in a group of 7,841 randomly selected blood donors who were screened for the ΔF508 mutation. We did not find any evidence for differences in number or sex ratio of offspring between ΔF508 carriers and non-carriers.
References
Danks DM, Allan J, Anderson CM (1965) A genetic study of fibrocystic disease of the pancreas. Ann Hum Genet 28:323–356
Gloria-Bottini F, Antonelli M, Quattrucci S et al (1980) Is there a relationship between sex of cystic fibrosis carriers and sex ratio of their offspring? Hum Genet 54:79–82
Jorde LB, Lathrop GM (1988) A test of heterozygote-advantage hypothesis in cystic fibrosis carriers. Am J Hum Genet 42:808–815
Kerem B-S, Rommens JM, Buchanan JA et al (1989) Identification of the cystic fibrosis gene: genetic analysis. Science 245:1073–1080
Pritchard DJ, Hickman GR, Nelson R (1983) Sex ratio and heterozygote advantage in cystic fibrosis families. Arch Dis Child 58:290–293
Ten Kate LP (1977) A method for analysing fertility of heterozygotes for autosomal recessive disorders, with special reference to cystic fibrosis, Tay-Sachs disease and phenylketonuria. Ann Hum Gent 40:287–297
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de Vries, H.G., Collée, J.M., Meeuwsen, W.P. et al. Number and sex of offspring of ΔF508 carriers outside cystic fibrosis families. Hum Genet 95, 575–576 (1995). https://doi.org/10.1007/BF00223873
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DOI: https://doi.org/10.1007/BF00223873