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Salivary proline-rich proteins

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Summary

Proline-rich proteins are major components of parotid and submandibular saliva in humans as well as other animals. They can be divided into acidic, basic and glycosylated proteins. The primary structure of the acidic proline-rich proteins is unique and shows that the proteins do not belong to any known family of proteins. The proline-rich proteins are apparently synthesized in the acinar cells of the salivary glands and their phenotypic expression is under complex genetic control.

The acidic proline-rich proteins will bind calcium with a strength which indicates that they may be important in maintaining the concentration of ionic calcium in saliva. Moreover they can inhibit formation of hydroxyapatite, whereby growth of hydroxyapatite crystals on the tooth surface in vivo may be avoided. Both of these activities as well as the binding site for hydroxyapatite are located in the N-terminal proline-poor part of the protein. Little is known about the functions of the glycosylated and basic proline-rich proteins.

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References

  1. Dawes, C., 1974. Arch. Oral Biol. 19: 887–894.

    Google Scholar 

  2. Dawes, C., 1969. Arch. Oral Biol. 14: 277–294.

    Google Scholar 

  3. Meyer, T. S. & Lamberts, B. L., 1968. Arch. Oral Biol. 13: 839–840.

    Google Scholar 

  4. Leach, S. A., Critchley, P., Kolendo, A. G. & Saxton, C. A., 1967. Caries Res. 1: 104–111.

    Google Scholar 

  5. Schneyer, L. H., 1956. J. Appl. Physiol. 9: 453–455.

    Google Scholar 

  6. Kauffman, D. L., Zager, N. I., Cohen, E. & Keller, P. J., 1970. Arch. Biochem. Biophys. 137: 325–339.

    Google Scholar 

  7. Bennick, A., 1975. Biochem. J. 145: 557–567.

    Google Scholar 

  8. Mandel, I. D., Thompson, R. H. & Ellison, S. A., 1965. Arch. Oral Biol. 10: 499–507.

    Google Scholar 

  9. Levine, M. & Keller, P. J., 1977. Arch. Oral Biol. 22:37–41.

    Google Scholar 

  10. Kauffman, D. L. & Keller, P. J., 1979. Arch. Oral Biol. 24: 249–256.

    Google Scholar 

  11. Bennick, A. & Connell, G. E., 1971. Biochem. J. 123: 455–464.

    Google Scholar 

  12. Schlesinger, D. H. & Hay, D. I., 1977. J. Biol. Chem. 252: 1689–1695.

    Google Scholar 

  13. Hay, D. I., 1975. Arch. Oral Biol. 20: 553–558.

    Google Scholar 

  14. Baum, B. J., Bird, J. L. & Longton, R. W., 1977. Arch. Oral Biol. 22: 455–456.

    Google Scholar 

  15. Bennick, A., 1977. Biochem. J. 163: 229–239.

    Google Scholar 

  16. Bennick, A., 1976. Biochem. J. 155: 163–169.

    Google Scholar 

  17. Wong, R. S. C., Hofmann, T. & Bennick, A., 1979. J. Biol. Chem. 254: 4800–4808.

    Google Scholar 

  18. Wong, R. S. C. & Bennick, A., 1981. J. Biol. Chem. 255: 5943–5948.

    Google Scholar 

  19. Wong, R. S. C. & Bennick, A., 1981. J. Dent. Res. 60A: 653.

    Google Scholar 

  20. Bennick, A., 1977. Biochem. J. 163: 241–245.

    Google Scholar 

  21. Deber, C. M., Bovey, F. A., Carver, J. P. & Blout, E. R., 1970. J. Amer. Chem. Soc. 92: 6191–6198.

    Google Scholar 

  22. Helbecque, N. & Loucheux-Lefebvre, M.-H., 1978. Int. J. Pept. Protein Res. 11: 353–362.

    Google Scholar 

  23. Oppenheim, F. G., Hay, D. I. & Franzblau, C., 1971. Biochemistry 10: 4233–4238.

    Google Scholar 

  24. Schlesinger, D. H. & Hay, D. I., 1979. Peptides. Proc. 6th American Peptide Symposium (Gross, E. & Meierhoffer, J. Eds.) pp. 133. Pierce Chem. Co., Rockford, 11.

  25. Hay, D. I. & Oppenheim, F. G., 1974. Arch. Oral Biol. 19: 627–632.

    Google Scholar 

  26. Friedman, R. D. & Merritt, A. D., 1975. Am. J. Hum. Genet. 27: 304–314.

    Google Scholar 

  27. Oppenheim, F. G., Kousvelari, E. & Troxler, R. F., 1979. Arch. Oral Biol. 24: 595–599.

    Google Scholar 

  28. Oppenheim, F. G., Kousvelari, E. & Troxler, R. F., 1979. Saliva and Dental Caries (Kleinberg, L, Ellison, S. A. & Mandel, I. D. Eds.) pp. 31–44. Information Retrieval, New York.

  29. Schlesinger, D. H. & Hay, D. I., 1981. Int. J. Pept. Protein Res. 17: 34–41.

    Google Scholar 

  30. Van Dyke, T. E., Levine, M. J., Herzberg, M. C., Ellison, S. A. & Hay, D. I., 1979. Arch. Oral Biol. 24: 85–89.

    Google Scholar 

  31. Fernandez-Sorenson, A. & Carlson, D. M., 1974. Biochem. Biophys. Res. Common. 60: 249–256.

    Google Scholar 

  32. Muenzer, J., Bildstein, C., Gleason, M. & Carlson, D. M., 1979. J. Biol. Chem. 254: 5623–5628.

    Google Scholar 

  33. Muenzer, J., Bildstein, C., Gleason, M. & Carlson, D. M., 1979. J. Biol. Chem. 254: 5629–5634.

    Google Scholar 

  34. Armstrong, W. G., 1971. Caries Res. 5: 215–227.

    Google Scholar 

  35. Arneberg, P., 1974. Arch. Oral Biol. 19: 921–928.

    Google Scholar 

  36. Keller, P. J., Kauffman, D. L., Bennick, A. & Wong, R. S. C., 1980. J. Dent. Res. 59A: 541.

    Google Scholar 

  37. Levine, M. J., Ellison, S. A. & Bahl, O. P., 1973. Arch. Oral Biol. 18: 827–837.

    Google Scholar 

  38. Kauffman, D. L. & Keller, P. J., 1979. J. Dent. Res. 58A: 392.

    Google Scholar 

  39. Isemura, S., Saitoh, E. & Sanada, K., 1979. J. Biochem. 86: 79–86.

    Google Scholar 

  40. Isemura, S., Saitoh, E. & Sanada, K., 1980. J. Biochem. 87: 1071–1077.

    Google Scholar 

  41. Keller, P. J., Robinovitch, M., Iversen, J. & Kauffman, D. L., 1975. Biochim. Biophys. Acta 379: 562–570.

    Google Scholar 

  42. Rajan, A. L, 1981. M. Sc. Thesis, University of Toronto.

  43. Andjic, J., Bonte, M. & Havez, R., 1970. C.R. Sceances Acad. Sci., Ser D. 270: 564–566.

    Google Scholar 

  44. Levine, M. J., Weill, J. C. & Ellison, S. A., 1969. Biochim. Biophys. Acta 188: 165–167.

    Google Scholar 

  45. Degand, P., Boersma, A., Roussel, P., Richet, C. & Biserte, G., 1975. FEBS Lett. 54: 189–192.

    Google Scholar 

  46. Li, H. C. & Levine, M. J., 1980. Arch. Oral Biol. 25: 353–355.

    Google Scholar 

  47. Shibata, S., Nagata, K., Nakamura, R., Tsunemitsu, A. & Misaki, A., 1980. J. Periodontol. 51: 499–504.

    Google Scholar 

  48. Aubert, J. P., Boersma, A., Loucheux-Lefebvre, M.-H., Degand, P. & Biserte, G., 1975. FEBS Lett. 56: 263–267.

    Google Scholar 

  49. Friedman, R. D., Merritt, A. D. & Bixler, D., 1971. Biochim. Biophys. Acta 230: 599–602.

    Google Scholar 

  50. Jacobsen, N. & Arneberg, P., 1976. Comp. Biochem. Physiol. 5413: 423–425.

    Google Scholar 

  51. Eastoe, J. E., 1960. Nature 187: 411–412.

    Google Scholar 

  52. Eggert, F. M., Allen, G. A. & Burgess, R. C. Biochem. J. 131:471-484.

  53. Fujimoto, D. & Kanaya, S., 1973. Arch. Biochem. Biophys. 157: 1–6.

    Google Scholar 

  54. Janusz, M., Lisowski, J. & Franck, F., 1974. FEBS Lett. 49:276–279.

    Google Scholar 

  55. Sainsbury, G. M. & Bullard, B., 1980. Biochem. J. 191: 333–339.

    Google Scholar 

  56. Sata, T., Havel, R. J., Kotite, L. & Kane, J. P., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 1063–1067.

    Google Scholar 

  57. Yu, P. L., Schwartz, R. C., Merritt, A. D., Azen, E. A., Rivas, M. L., Karn, R. C. & Craft, M. A., 1978. Cytogenet. Cell Genet. 22: 655–658.

    Google Scholar 

  58. Azen, E. A., 1978. Biochem. Genet. 16: 79–99.

    Google Scholar 

  59. Karn, R. C., Friedman, R. D. & Merritt, A. D., 1979. Biochem. Genet. 17: 1061–1077.

    Google Scholar 

  60. Azen, E. A. & Denniston, C., 1981. Biochem. Genet. 19: 475–485.

    Google Scholar 

  61. Azen, E. A., Hurley, C. K. & Denniston, C., 1979. Biochem. Genet. 17: 257–279.

    Google Scholar 

  62. Ikemoto, S., Minaguchi, K., Suzuki, K. & Tomita, K., 1976. Science 197: 378–379.

    Google Scholar 

  63. Azen, E. A. & Denniston, C., 1980. Biochem. Genet. 18: 483–501.

    Google Scholar 

  64. Minaguchi, K., Ikemoto, S. & Suzuki, K., 1981. Biochem. Genet. 19: 617–621.

    Google Scholar 

  65. Ziemer, M., Gleason, M. & Carlson, D., 1979. Abstracts, 111th International Congress of Biochemistry, p. 122.

  66. Azen, E. A., 1978. Arch. Oral Biol. 23: 1173–1176.

    Google Scholar 

  67. Schachter, H., 1978. The Glycoconjugates (Horowitz, M. A. & Pigman, W. Eds.) Vol. 2, pp. 87–181. Academic Press, New York.

  68. Örstavik, T. B., 1980. J. Histochem. Cytochem. 28: 881–889.

    Google Scholar 

  69. Bennick, A., Wong, R. & Cannon, M., 1977. Calcium Binding Proteins and Calcium Function (Wasserman, R. H., Corradino, R. A., Carafoli, E., Kretsinger, R. H., MacLennan, D. H. & Siegel, F. L. Eds.) pp. 391–400. North Holland, New York.

  70. Kousvelari, E. E., Baratz, R. S., Burke, B. & Oppenheim, F. G., 1980. J. Dent. Res. 59: 1430–1438.

    Google Scholar 

  71. Kousvelari, E. E., Oppenheim, F. G. & Cutler, L. S., 1981. J. Dent. Res. 60: 396.

    Google Scholar 

  72. Chan, J., Rajan, A., Bennick, A. & Pinteric, L., 1981. J. Dent. Res. 60: 397.

    Google Scholar 

  73. Amsterdam, A., Schramm, M., Ohad, I., Salomon, Y. & Selinger, Z., 1971. J. Cell Biol. 50: 187–200.

    Google Scholar 

  74. Robinovitch, M. R., Keller, P. J., Iversen, J. & Kauffman, D. L., 1975. Biochim. Biophys. Acta 382: 260–264b.

    Google Scholar 

  75. Robinovitch, M. R., Iversen, J. M. & Oberg, S. G., 1980. Arch. Oral Biol. 25: 523–530.

    Google Scholar 

  76. Arneberg, P., Helgeland, K. & Tjörnholm, T., 1976. Arch. Oral Biol. 21: 379–383.

    Google Scholar 

  77. Amsterdam, A., Ohad, I. & Schramm, M., 1969. J. Cell Biol. 41: 753–773.

    Google Scholar 

  78. Selye, H., Veilleux, R. & Cantin, M., 1961. Science 133: 44–45.

    Google Scholar 

  79. Robinovitch, M. R., Keller, P. J., Johnson, D. A., Iversen, J. M. & Kauffman, D. L., 1977. J. Dent. Res. 56: 290–303.

    Google Scholar 

  80. Johnson, D. A., 1980. J. Dent. Res. 59: 541.

    Google Scholar 

  81. Grön, P., 1973. Arch. Oral Biol. 18: 1365–1378.

    Google Scholar 

  82. Bennick, A. & Cannon, M., 1978. Caries Res. 12: 159–169.

    Google Scholar 

  83. Bennick, A., McLaughlin, A. C., Grey, A. A. & Madapallimattam, G., 1981. J. Biol. Chem. 256: 4741–4746.

    Google Scholar 

  84. Bernardi, G., 1971. Methods Enzymol. 22: 325–339.

    Google Scholar 

  85. Hay, D. I., 1967. Arch. Oral Biol. 12: 937–946.

    Google Scholar 

  86. Hay, D. I., 1973. Arch. Oral Biol. 18: 1517–1530.

    Google Scholar 

  87. Bennick, A., Cannon, M. & Madapallimattam, G., 1981. Caries Res. 15: 9–20.

    Google Scholar 

  88. Moreno, E. C., Kresak, M. & Hay, D. I., 1978. Arch. Oral Biol. 23: 525–534.

    Google Scholar 

  89. Kresak, M., Moreno, E. C. & Hay, D. I., 1978. J. Dent. Res. 57: 284.

    Google Scholar 

  90. Kresak, M., Moreno, E. C. & Hay, D. I., 1981. J. Dent. Res. 60: 653.

    Google Scholar 

  91. Bennick, A., Cannon, M. & Madapallimattam, G., 1979. Biochem. J. 183: 115–126.

    Google Scholar 

  92. Choih, S.-J., Smith, Q. T. & Schachtele, C. F., 1979. J. Dent. Res. 58: 516–524.

    Google Scholar 

  93. Grön, P., 1973. Arch. Oral Biol. 18: 1385–1392.

    Google Scholar 

  94. Tomazic, B., Tomson, M. & Nancollas, G. H., 1976. Calcif. Tissue Res. 19: 263–271.

    Google Scholar 

  95. Hay, D. I. & Grön, P., 1977. Microbial Aspects of Dental Caries (Stiles, W. J., Loesche, W. I. & O'Brien, T. C. Eds.) Vol l, pp. 143–150. Information Retreival, Washington.

  96. Hay, D. I. & Moreno, E. C., 1979. J. Dent. Res. 58B: 930–940.

    Google Scholar 

  97. Moreno, E. L., Varughese, K. & Hay, D. I., 1979. Calcif. Tissue Int. 28: 7–16.

    Google Scholar 

  98. Meyer, J. L. & Nancollas, G. H., 1973. Calcif. Tissue Res. 13:295–303.

    Google Scholar 

  99. Bennick, A., 1981. Chemistry and Biology of Mineralized Connective Tissue (Veis, A. Ed.) North Holland, New York.

  100. Hay, D. I., Moreno, E. C. & Schlesinger, D. H., 1979. Inorg. Perspect. Biol. Med. 2: 271–285.

    Google Scholar 

  101. Ericson, T., 1967. Caries Res. 1: 52–53.

    Google Scholar 

  102. McGaughey, C. & Stowell, E. C., 1967. Arch. Oral Biol. 12: 815–818.

    Google Scholar 

  103. Mayhall, C. W., 1970. Arch. Oral Biol. 15: 1327–1341.

    Google Scholar 

  104. Sbnju, T. & Rolla, G., 1973. Caries Res. 7: 30–38.

    Google Scholar 

  105. Lie, T., 1977. Scand. J. Dent. Res. 85: 217–231.

    Google Scholar 

  106. Armstrong, W. G. & Hayward, A. F., 1968. Caries Res. 2: 294–305.

    Google Scholar 

  107. Madapallimattam, G., Abrams, S., Hoffman, R., Tustian, D., Goodlin, R., Chau, G. & Bennick, A., 1981. J. Dent. Res. 60: 573.

    Google Scholar 

  108. Zahradnik, R. T., Moreno, E. C. & Burke, E. J., 1976. J. Dent. Res. 55: 664–670.

    Google Scholar 

  109. Gibbons, R. J., 1979. Saliva and Dental Caries (Kleinberg, L, Ellison, S. A. & Mandel, I. D. Eds.) pp. 267–273. Information Retreival, New York.

  110. Levine, M. J., Herzberg, M. C., Levine, M. S., Ellison, S. A., Stinson, M. W., Li, H. C. & Van Dyke, T., 1978. Infect. Immun. 19: 107–115.

    Google Scholar 

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  1. Dept. of Biochemistry, University of Toronto, 1A8, Toronto, M5S, Canada

    A. Bennick

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Bennick, A. Salivary proline-rich proteins. Mol Cell Biochem 45, 83–99 (1982). https://doi.org/10.1007/BF00223503

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