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Quantitative genetic dissection of complex traits in a QTL-mapping pedigree

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Abstract

This paper summarizes and modifies quantitative genetic analyses on a pedigree used to map genetic factors (i.e., QTLs) underlying a complex trait. The total genetic variance can be exactly estimated based on the F2 family derived from two homozygous parents for alternative alleles at all QTLs of interest. The parents, F1 hybrids, and two backcrosses are combined to each parent, and the total number of QTLs and the number of dominant QTLs are estimated under the assumptions of gene association with the two parents, equal gene effect, no linkage, and no epistasis among QTLs. Further relaxation for each of the assumptions are made in detail. The biometric estimator for the QTL number and action mode averaged over the entire genome could provide some basic and complementary information to QTL mapping designed to detect the effect and location of specific genetic factors.

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  1. R. L. Wu

    Present address: Forest Biotechnology Group, College of Forest Resources, Box 8008, North Carolina State University, 27695-8008, Raleigh, NC, USA

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  1. College of Forest Resources, University of Washington, 98198-2100, Seattle, WA, USA

    R. L. Wu

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Communicated by J. MacKey

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Wu, R.L. Quantitative genetic dissection of complex traits in a QTL-mapping pedigree. Theoret. Appl. Genetics 93, 447–457 (1996). https://doi.org/10.1007/BF00223189

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  • DOI: https://doi.org/10.1007/BF00223189

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