Summary
This review summarizes studies on the structural organization of Ca2+-ATPase in the sarcoplasmic reticulum membrane in relation to the function of the transport protein. Recent advances in this field have been made by a combination of protein-chemical, ultrastructural, and physicochemical techniques on membraneous and detergent solubilized ATPase. A particular feature of the ATPase (Part I) is the presence of a hydrophilic ‘head’, facing the cytoplasm, and a ‘tail’ inserted in the membrane. In agreement with this view the protein is moderately hydrophobic, compared to many other integral membrane proteins, and the number of traverses of the 115 000 Dalton peptide chain through the lipid may be limited to 3–4.
There is increasing evidence (Part II) that the ATPase is self-associated in the membrane in oligomeric form. This appears to be a common feature of many transport proteins. Each ATPase peptide seems to be able to perform the whole catalytic cycle of ATP hydrolysis and Ca2+ transport. Protein-protein interactions seem to have a modulatory effect on enzyme activity and to stabilize the enzyme against inactivation.
Phospholipids (Part III) are not essential for the expression of enzyme activity which only requires the presence of flexible hydrocarbon chains that can be provided e.g. by polyoxyethylene glycol detergents. Perturbation of the lipid bilayer by the insertion of membrane protein leads to some immobilization of the lipid hydrocarbon chains, but not to the extent envisaged by the annulus hypothesis. Strong immobilization, whenever it occurs, may arise from steric hindrance due to protein-protein contacts. Recent studies suggest that breaks in Arrhenius plots of enzyme activity primarily reflect intrinsic properties of the protein rather than changes in the character of lipid motion as a function of temperature.
Similar content being viewed by others
References
MacLennan, D. H. & Holland, P. C., 1976. In: The Enzymes of Biological Membranes (Martonosi, A., ed.) Plenum, New York, pp. 221–259.
Tada, M., Yamamoto, T. & Tonomura, Y., 1978. Physiol. Rev. 58: 1–79.
Hasselbach, W., 1978. Biochim. Biophys. Acta 463: 23–53.
de Meis, L. & Vianna, A., 1979. Annu. Rev. Biochem. 48: 275–292.
Bennett, J. P., McGill, K. A. & Warren, G. B., 1980. In lsCurrent Topics in Membranes and Transport’ 14: 127–164.
MacLennan, D. H., Seeman, P., Iles, G. H. & Yip, C. C., 1971. J. Biol. Chem. 246: 2702–2710.
MacFarland, B. H. & Inesi, G., 1971. Arch. Biochem. Biophys. 145: 456–464.
Louis, C. & Shooter, E. M., 1972. Arch. Biochem. Biophys. 153: 641–655.
Meissner, G., Conner, G. E. & Fleischer, S., 1973. Biochim. Biophys. Acta 298: 246–269.
Thorley-Lawson, D. A. & Green, N. M., 1973. Eur. J. Biochem. 40: 403–413.
Warren, G. B., Toon, P. A., Birdsall, N. J. M., Lee, A. G. & Metcalfe, J. C., 1974. Proc. Nat. Acad. Sci. USA 71: 622–626.
Fairbanks, G., Steck, T. L. & Wallach, D. F. H., 1971. Biochemistry 10: 2606–2617.
Weber, K. & Osborn, M., 1969. J. Biol. Chem. 244: 4406–4412.
Craig, W. S. & Kyte, J., 1980. J. Biol. Chem. 255: 6262–6269.
Esmann, M., Christiansen, C., Karlsson, K.-A., Hansson, G. C. H. & Skou, J. C., 1980. Biochim. Biophys. Acta 603: 1–12.
Rizzolo, L., le Maire, M., Reynolds, J. A. & Tanford, C., 1976. Biochemistry 15: 3433–3437.
le Maire, M., Jørgensen, K. E., Røigaard-Petersen, H. & Møller, J. V., 1976. Biochemistry 15: 5805–5812.
le Maire, M., Møller, J. V. & Tardieu, A., 1981. J. Mol. Biol. (in press).
Martonosi, A. & Halpin, R. A., 1971. Arch. Biochem. Biophys. 144: 66–77.
Thorley-Lawson, D. A. & Green, N. M., 1975. Eur. J. Biochem. 59: 193–200.
Capaldi, R. A. & Vanderkooi, G., 1972. Proc. Nat. Acad. Sci. USA 69: 930–932.
Allen, G., Trinnaman, B. J. & Green, N. M., 1980. Biochem. J. 187: 591–616.
Yamanaka, N. & Deamer, W., 1976. Biochim. Biophys. Acta 426: 132–147.
Green, N. M., Hebdon, G. M. & Thorley-Lawson, D. A., 1978. FEBS Symp. 45: 149–157.
Green, N. M., Allen, G. & Hebdon, G. M., 1981. Ann. N.Y. Acad. Sci. (in press).
Murphy, A. J., 1976. Biochemistry 15: 4492–4496.
Thorley-Lawson, D. A. & Green, N. M., 1977. Biochem. J. 167: 739–748.
Andersen, J. P. & Møller, J. V., 1977. Biochim. Biophys. Acta 485: 188–202.
Allen, G., 1980. Biochem. J. 187: 545–563.
Allen, G., 1980. Biochem. J. 187: 565–575.
Allen, G., Bottomley, R. C. & Trinnaman, B. J., 1980. Biochem. J. 187: 577–589.
Tong, S. W., 1977. Biochem. Biophys. Res. Comm. 74: 1242–1248.
Degani, C. & Boyer, P. D., 1973. J. Biol. Chem. 248: 8222–8226.
Bastide, F., Meissner, G., Fleischer, S. & Post, R. L., 1973. J. Biol. Chem. 248: 8385–8391.
Allen, G. & Green, N. M., 1976. FEBS Lett. 63: 188–192.
Hardwicke, P. M. D. & Green, N. M., 1974. Eur. J. Biochem. 42: 183–193.
Liljas, A. & Rossman, M. G., 1974. Annu. Rev. Biochem. 43: 475–507.
Migala, A., Agostini, B. & Hasselbach, W., 1973. Z. Naturforsch. 28: 178–182.
Stewart, P. S. & McLennan, D. H., 1974. J. Biol. Chem. 249: 985–993.
Louis, C., Buohaffina, R. & Binks, B., 1974. Arch. Biochem. Biophys. 161: 83–92.
Inesi, G. & Scales, D., 1974. Biochemistry 13: 3298–3306.
Stewart, P. S., MacLennan, D. H. & Shamoo, A. E., 1976. J. Biol. Chem. 251: 712–719.
MacLennan, D. H., Khanna, V. K. & Stewart, P. S., 1976. J. Biol. Chem. 251: 7271–7274.
Shamoo, A. E., Ryan, T. E., Stewart, P. S. & MacLennan, D. H., 1976. J. Biol. Chem. 251: 4147–4154.
Rizzolo, L. J. & Tanford, C., 1978. Biochemistry 17: 4044–4048.
Rizzolo, L. J. & Tanford, C., 1978. Biochemistry 17: 4049–4055.
Ikemoto, N., Sreter, F. A. & Gergely, J., 1971. Arch. Biochem. Biophys. 147: 571–582.
Saito, A., Wang, C.-T. & Fleischer, S., 1978. J. Cell. Biol. 79: 601–616.
Klip, A., Reithmeyer, R. A. F. & MacLennan, D. H., 1980. J. Biol. Chem. 255: 6562–6568.
Tong, S. W., 1980. Arch. Biochem. Biophys. 203: 780–791.
Tanford, C. & Reynolds, J. A., 1976. Biochim. Biophys. Acta 457: 133–170.
Shamoo, A. E., 1978. J. Membr. Biol. 43: 227–242.
Pick, U. & Racker, E., 1979. Biochemistry 18: 108–113.
Stephens, E. M. & Grisham, C. M., 1979. Biochemistry 18: 4876–4885.
de Meis, L., Martins, O. B. & Alvez, E. W., 1980. Biochemistry 19: 4252–4261.
Hasselbach, W. & Elfvin, L.-G., 1967. J. Ultrastr. Res. 17: 598–622.
Hidalgo, C. & Ikemoto, N., 1977. J. Biol. Chem. 252: 8446–8454.
Stewart, P. S., MacLennan, D. H. & Shamoo, A. E., 1976. J. Biol. Chem. 251: 712–719.
Greaser, M. C., Cassens, R. G., Hoekstra, W. G. & Briskey, E. J., 1969. J. Cell. Physiol. 75: 37–50.
Inesi, G. & Asai, I., 1968. Arch. Biochem. Biophys. 126: 469–477.
Deamer, D. W. & Baskin, R. J., 1969. J. Cell. Biol. 43: 296–330.
Jilka, R. L., Martonosi, A. N. & Tillack, T. W., 1975. J. Biol. Chem. 250: 7511–7524.
Ikemoto, N., Sreter, F. A., Nakamura, A. & Gergely, J., 1968. J. Ultrastr. Res. 23: 216–232.
Dupont, Y., Harrison, S. C. & Hasselbach, W., 1973. Nature 244: 555–558.
Liu, S. C. & Worthington, C. R., 1974. Arch. Biochem. Biophys. 163: 332–342.
Herbette, L., Marquardt, J., Scarpa, A., Blaisie, J. K., 1977. Biophys. J. 20: 245–272.
Fleischer, S., Wang, C.-T., Hymel, L., Seelig, J., Brown, M. F., Herbette, L., Scarpa, A., McLaughlin, A. C. & Blaisie, J. K., 1979. In: ‘Function and Molecular Aspects of Biomembrane Transport’. (Quagliariello, E., Palmieri, F., Papa, S. & Klingenberg, M., eds.), Biomedical Press, Elsevier North-Holland, pp. 465–485.
Bertaud, W. S., Rayns, D. G. & Simpson, F. O., 1970. J. Cell. Sci. 6: 537–557.
Scales, D. & Inesi, G., 1976. Biophys. J. 16: 735–751.
Packer, L., Mehard, C. W., Meissner, G., Zahler, W. L. & Fleischer, S., 1974. Biochim. Biophys. Acta 363: 159–181.
Wang, C.-T., Saito, A. & Fleischer, S., 1979. J. Biol. Chem. 254: 9209–9219.
Chevallier, J., Bonnet, J.-P., Galante, M., Tenu, J.-P. & Gulik-Krzywicki, T., 1977. Biol. Cell. 30: 103–110.
Sarzala, M. G. & Michalak, M., 1978. Biochim. Biophys. Acta 513: 221–235.
Luzzati, V. & Tardieu, A., 1980. Annu. Rev. Biophys. Bioeng. 9: 1–29.
le Maire, M., Meller, J. V. & Gulik-Krzywicki, T., 1981. Biochim. Biophys. Acta 643: 115–125.
Singer, S. J. & Nicholson, G. L., 1972. Science 175: 720–731.
Henderson, R. & Unwin, P. N. T., 1975. Nature 257: 28–32.
Henderson, R., 1980. Nature 287: 390.
le Maire, M., Møller, J. V. & Tanford, C., 1976. Biochemistry 2336–2342.
le Maire, M., Lind, K. E., Jørgensen, K. E., Røigaard, H. & Møller, J. V., 1978. J. Biol. Chem. 253: 7051–7060.
Jørgensen, K. E., Lind, K. E., Røigaard-Petersen, H. & Møller, J. V., 1978. Biochem. J. 169: 489–498.
Møller, J. V., Lind, K. E. & Andersen, J. P., 1980. J. Biol. Chem. 255: 1912–1920.
Dean, W. L. & Tanford, C., 1977. J. Biol. Chem. 252: 3551–3553.
Dean, W. L. & Tanford, C., 1978. Biochemistry 17: 1683–1690.
le Maire, M. & Møller, J. V. (unpublished observations).
86. Møller, J. V. & Andersen, J. P. (unpublished observation).
Yates, D. W. & Duance, V. C., 1976. Biochem. J. 159: 719–728.
Andersen, J. P., le Maire, M. & Møller, J. V., 1980. Biochim. Biophys. Acta 603: 84–100.
Andersen, J. P., Fellmann, P., Møller, J. V. & Devaux, P. F., 1981. Biochemistry (in press).
Yeh, Y., Selser, J. C. & Baskin, R. J., 1978. Biochim. Biophys. Acta 509: 78–89.
Murphy, A. J., 1976. Biochem. Biophys. Res. Comm. 70: 160–166.
Baskin, R. J. & Hanna, S., 1979. Biochim. Biophys. Acta 576: 61–70.
Chyn, T. & Martonosi, A., 1977. Biochim. Biophys. Acta 468: 114–126.
Hebdon, G. M., Cunningham, L. W. & Green, N. M., 1979. Biochem. J. 179: 135–139.
Branton, D. & Deamer, D. W., 1972. Membrane structure. Protoplasmologia. II,E,1. Springer Verlag, New York.
Cherry, R. J., Müller, U., Henderson, R. & Heyn, M. P., 1978. J. Mol. Biol. 121: 283–298.
Cherry, R. J., 1979. Biochim. Biophys. Acta 559: 289–327.
Skriver, E., Maunsbach, A. B. & Jørgensen, P. L., 1980. J. Cell. Biol. 86: 746–754.
Vanderkooi, J. M., Ierokomas, A., Nakamura, H. & Martonosi, A., 1977. Biochemistry 16: 1262–1267.
Thomas, D. D. & Hidalgo, C., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 5488–5492.
Kirino, Y., Ohkuma, T. & Shimizu, H., 1978. J. Biochem. (Tokyo) 84: 111–115.
Thomas, D. D., 1978. Biophys. J. 24: 439–462.
Hidalgo, C., Thomas, D. D. & Ikemoto, N., 1978. J. Biol. Chem. 253: 6879–6887.
Hoffmann, W., Sarzala, M. G. & Chapman, D., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 3860–3864.
Bürkli, A. & Cherry, R. J., 1981. Biochemistry 20: 138–145.
Cone, R. A., 1972. Nature New Biol. 236: 39–43.
Tanford, C., 1977. FEBS Symp. 45: 3–11.
Hastings, D. F. & Reynolds, J. A., 1979. Biochemistry 18: 817–821.
Clarke, S., 1975. J. Biol. Chem. 250: 5459–5469.
Brotherus, J. R., Møller, J. V. & Jørgensen, P. L., 1981. Biochim. Biophys. Res. Comm. 100: 146–154.
Deguchi, N., Jørgensen, P L. & Maunsbach, A. B., 1977. J. Cell. Biol. 75: 619–634.
Haase, W. & Koepsell, H., 1979. Pfl. Arch. 381: 127–135.
Giotta, G. J., 1976. Biochem. Biophys. Res. Comm. 71: 776–782.
Giotta, G. J., 1976. J. Biol. Chem. 251: 1247–1252.
Liang, S.-M. & Winter, C. G., 1977. J. Biol. Chem. 252: 8278–8284.
Jørgensen, P. L., 1980. Physiol. Rev. 60: 864–917.
Nigg, E. A. & Cherry, R. J., 1979. Nature 277: 493–494.
Nigg, E. A. & Cherry, R. J., 1979. Biochemistry 18: 3457–3465.
Weinstein, R. S., Khodadad, J. K. & Steck, T., 1980. In: Membrane Transport in Erythrocytes, Alfred Benzon Symp. 14 (Lassen, U. V., Ussing, H. H. & Wieth, J. D., eds.), pp. 35–58.
Steck, T. L., 1972. J. Mol. Biol. 66: 295–305.
Peters, K. & Richards, F. M., 1977. Annu. Rev. Biochem. 46: 523–551.
Riccio, P., Aquila, H. & Klingenberg, M., 1975. FEBS Lett. 56: 133–138.
Hackenberg, H. & Klingenberg, M., 1980. Biochemistry 19: 548–555.
Brandolin, G., Meyer, C., Defaye, G., Vignais, P. M., Vignais, P. V., 1974. FEBS Lett. 46: 149–153.
Vignais, P. V., Vignais, P. M., Lanquin, G. & Morel, F., 1973. Biochimie 55: 763–768.
Aquila, H., Eiermann, W., Babel, W. & Klingenberg, M., 1978. Eur. J. Biochem. 85: 549–560.
Dupont, Y., 1977. Eur. J. Biochem. 72: 185–190.
Neet, K. E. & Green, N. M., 1977. Arch. Biochem. Biophys. 178: 588–597.
Masudo, H. & de Meis, L., 1973. Biochemistry 13: 2057–2062.
Kanazawa, T., 1975. J. Biol. Chem. 250: 113–119.
de Meis, L. & Boyer, P. D., 1978. J. Biol. Chem. 253: 1556–1559.
Pick, U. & Karlish, S. J. D., 1980. Biochim. Biophys. Acta 626: 255–261.
Fassold, E., Chak, D. V. & Hasselbach, W., 1981. Eur. V. Biochem. 113: 611–616.
Dutton, A., Rees, E. D. & Singer, S. J., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 1532–1536.
Dupont, Y. & Leigh, J. B., 1978. Nature 273: 396–398.
Coan, C. R. & Inesi, G., 1977. J. Biol. Chem. 252: 3044–3049.
Murphy, A. J., 1978. J. Biol. Chem. 253: 385–389.
Francois, C., 1969. Biochim. Biophys. Acta 173: 86–93.
Martonosi, A. & Fortier, F., 1974. Biochem. Biophys. Res. Comm. 60: 382–389.
Sumida, M. & Sasaki, S., 1975. J. Biochem. (Tokyo) 78: 757–762.
Champeil, P., Rigaud, J.-L. & Gary-Bobo, C. M., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 2405–2409.
Tonomura, Y. & Morales, M. F., 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 3687–3691.
Yamamoto, T. & Tonomura, Y., 1977. J. Biochem. (Tokyo) 82: 653–660.
Champeil, P., Büschlen-Boucly, S., Bastide, F. & Gary-Bobo, C., 1978. J. Biol. Chem. 253: 1179–1186.
Meissner, G., Conner, G. E. & Fleischer, S., 1973. Biophys. Acta 298: 246–269.
McLennan, D. H., Seeman, P., Iles, G. H. & Yip, C. C., 1971. J. Biol. Chem. 246: 2702–2710.
Shigekawa, M., Finegan, J.-A. M. & Katz, A. M., 1976. J. Biol. Chem. 251: 6894–6900.
Pang, D. C. & Briggs, F. N., 1977. J. Biol. Chem. 252: 3262–3266.
Pucell, A. & Martonosi, A., 1971. J. Biol. Chem. 246: 3389–3394.
Froehlich, J. P. & Taylor, E. W., 1975. J. Biol. Chem. 250: 2013–2021.
Froehlich, J. P. & Taylor, E. W., 1976. J. Biol. Chem. 251: 2307–2315.
Sumida, M., Kanazawa, T. & Tonomura, Y., 1976. J. Biochem. (Tokyo) 79: 259–264.
Kurzmack, M. & Inesi, G., 1976. FEBS Lett. 74: 35–37.
Verjovski-Almeida, S., Kurzmack, M. & Inesi, G., 1978. Biochemistry 17: 5006–5013.
Grosse, R., Rapoport, T., Malur, J., Fischer, J. & Repke, K. R. H., 1979. Biochim. Biophys. Acta 550: 500–514.
Martonosi, A., Donley, J. & Halpin, R. A., 1968. J. Biol. Chem. 243: 61–70.
Fiehn, W. & Hasselbach, W., 1970. Eur. J. Biochem. 13: 510–518.
Meissner, G. & Fleischer, S., 1972. Biochim. Biophys. Acta 255: 19–33.
Nestruck-Goyke, A.C. & Hasselbach, W., 1981. Eur. J. Biochem. 114: 339–347.
Knowles, A. F., Eytan, E. & Racker, E., 1976. J. Biol. Chem. 251: 5161–5165.
Green, N. M., 1975. In: ‘Calcium Transport in Contraction and Secretion’ (Carafoli, E., ed.) North-Holland Publishing Co.
Moore, B. M., Lentz, B. R. & Meissner, G., 1978. Biochemistry 17: 5248–5255.
Nakamura, M. & Ohnishi, S., 1975. J. Biochem. (Tokyo) 78: 1039–1045.
Warren, G. B., Toon, P. A., Birdsall, N. J. M., Lee, A. G. & Metcalfe, J. C., 1974. Biochemistry 13: 5501–5507.
Warren, G. B. & Metcalfe, J. C., 1976. In: ‘Structural and Kinetic Approach to Plasma Membrane Functions’ (Nicolau, C. & Paraf, A., eds.), Springer Verlag, pp. 188–200.
Zimniak, P. & Racker, E., 1978. J. Biol. Chem. 253: 4631–4637.
Melgunov, V. I. & Akimova, E. I., 1980. FEBS Lett. 121: 235–238.
Marcelja, S., 1976. Biochim. Biophys. Acta 455: 1–7.
Nakamura, H., Jilka, R. J., Boland, R. & Martonosi, A. N., 1976. J. Biol. Chem. 251: 5414–5423.
Hidalgo, C., Ikemoto, N. & Gergely, J., 1976. J. Biol. Chem. 251: 4224–4232.
Nakamura, H. & Martonosi, A. N., 1980. J. Biochem. (Tokyo) 87: 525–534.
Warren, G. B., Houslay, M. D., Metcalfe, J. C. & Birdsall, N. J. M., 1975. Nature 255: 684–687.
Madden, T. D., Chapman, D. & Quinn, P. J., 1979. Nature 279: 538–541.
Madden, T. D., King, M. D. & Quinn, P. J., 1981. Biochim. Biophys. Acta 641: 265–269.
Madden, T. D. & Quinn, P. J., 1979. FEBS Lett. 107: 110–112.
Lenaz, G., Curatola, G., Mazzanti, L. & Parenti-Castelli, G., 1978. Mol. Cell. Biochem. 22: 3–32.
Chapman, D., Gomez-Fernandez, J. C. & Goni, F. M., 1979. FEBS Lett. 98: 211–223.
Favre, E., Baroin, A., Bienvenue, A. & Devaux, P. F., 1979. Biochemistry 18: 1156–1162.
Knowles, P. F., Watts, A. & Marsh, D., 1979. Biochemistry 18: 4480–4487.
Hesketh, T. R., Smith, G. A., Houslay, M. D., McGill, K. A., Birdsall, N. J. M., Metcalfe, J. C. & Warren, G. B., 1976. Biochemistry 15: 4145–4151.
Jost, P. C., Griffith, O. H., Capaldi, R. A. & Vanderkooi, G., 1973. Proc. Natl. Acad. Sci. U.S.A. 70: 480–484.
Owicki, J. C., Springgate, M. W. & McConnell, H. M., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 1616–1619.
Owicki, J. C. & McConnell, H. M., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 4750–4754.
Robinson, J. D., Birdsall, N. J. M., Lee, A. G. & Metcalfe, J. C., 1972. Biochemistry 11: 2903–2909.
Davis, D. G. & Inesi, G., 1971. Biochim. Biophys. Acta 241: 1–8.
Davis, D. G., Inesi, G. & Gulik-Krzywicki, T., 1976. Biochemistry 15: 1271–1276.
Stoffel, W., Zierenberg, O. & Scheefers, H., 1977. Hoppe-Seyler's Z. Physiol. Chem. 358: 865–882.
Rice, D. M., Meadows, M. D., Scheinman, A. O., Goni, F. M., Gomez-Fernandez, J. C., Moscarello, M. A., Chapman, D. & Oldfield, E., 1979. Biochemistry 18: 5893–5903.
Davoust, J., Schoot, B. M. & Devaux, P. F., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 2755–2759.
Davoust, J., Bienvenue, A., Fellmann, P. & Devaux, P. F., 1980. Biochim. Biophys. Acta 596: 28–42.
Fellman, P., Andersen, J., Devaux, P. F., le Maire, M. & Bienvenue, A., 1980. Biochem. Biophys. Res. Comm. 95: 289–295.
Swanson, M. S., Quintanilha, A. T. & Thomas, D. D., 1980. J. Biol. Chem. 255: 7494–7502.
Scandella, C. J., Devaux, P. & McConnell, H. M., 1972. Proc. Natl. Acad. Sci. 69: 2056–2060.
Kang, S. Y., Gutowsky, H. S., Hsung, J. C., Jacobs, R., King, T. E., Rice, D. & Oldfield, E., 1979. Biochemistry 18: 3257–3267.
Gomez-Fernandez, J. C., Goni, F. M., Bach, D., Restall, C. J. & Chapman, D., 1979. FEBS Lett. 98: 224–228.
Gomez-Fernandez, J. C., Goni, F. M., Bach, D., Restall, C. J. & Chapman, D., 1980. Biochim. Biophys. Acta 598: 502–516.
Hoffmann, W., Sarzala, M. G., Gomez-Fernandez, J. C., Goni, F. M., Restall, C. J., Chapman, D., Heppeler, G. & Kreutz, W., 1980. J. Mol. Biol. 141: 119–132.
Kleeman, W. & McConnell, H. M., 1976. Biochim. Biophys. Acta 419: 206–222.
Inesi, G., Millman, M. & Eletr, S., 1973. J. Mol. Biol. 81: 483–504.
Deamer, D. W., 1973. J. Biol. Chem. 248: 5477–5485.
Madeira, V. M. C., Antunez-Madeira, M. C. & Carvalho, A. P, 1974. Biochem. Biophys. Res. Comm. 58: 897–904.
Lee, A. G., Birdsall, N. J. M., Metcalfe, J. C., Toon, P. A. & Warren, G. B., 1974. Biochemistry 13: 3699–3705.
Anzai, K., Kirino, Y. & Shimizu, H., 1978. J. Biochem. (Tokyo) 84: 815–821.
Chapman, D., 1975. Q. Rev. Biophys. 8: 185–235.
Wu, S. H. & McConnell, H. M., 1975. Biochemistry 14: 847–854.
Kaizu, T., Kirino, Y. & Shimizu, H., 1980. J. Biochem. (Tokyo) 88: 1837–1844.
Chen, Y. S. & Hubbell, W. L., 1973. Exp. Eye Res. 17: 517–532.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moller, J.V., Andersen, J.P. & le Maire, M. The sarcoplasmic reticulum Ca2+-ATPase. Mol Cell Biochem 42, 83–107 (1981). https://doi.org/10.1007/BF00222696
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00222696