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The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes

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Abstract

CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a sub-population of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.

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Authors and Affiliations

  1. Department of Genetics, University of Helsinki, Arkadiankatu 7, SF-00100, Helsinki, Finland

    Kimmo I. Virtaneva & Jim Schröder

  2. Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Vídenská 1083, 14220, Praha 4, Czechoslovakia

    Pavla Angelisová & Václav Hořejší

  3. Department of Immunopharmacology, Sandoz Research Institute Ltd., Brunnestr. 59, A-1235, Vienna, Austria

    Thomas Baumruker

  4. Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, SF-00290, Helsinki, Finland

    Heli Nevanlinna

Authors
  1. Kimmo I. Virtaneva
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  2. Pavla Angelisová
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  3. Thomas Baumruker
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  4. Václav Hořejší
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  5. Heli Nevanlinna
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  6. Jim Schröder
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Virtaneva, K.I., Angelisová, P., Baumruker, T. et al. The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. Immunogenetics 37, 461–465 (1993). https://doi.org/10.1007/BF00222471

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