Abstract
Two heart muscarinic responses are compared, the reduction of cyclic AMP concentration and the hydrolysis of phosphoinositides. It is suggested that the former is more important physiologically, since the latter is a slow response requiring much higher agonist concentrations. Inositol trisphosphate released from phosphoinositides is unlikely to produce a positive inotropic effect by releasing calcium from the sarcoplasmic reticulum. However, long term muscarinic effects may involve activation of protein kinase C by diacylglycerol released from phosphoinositides.
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Hawthorne, J.N., Simmonds, S.H. Second messengers involved in the muscarinic control of the heart: the role of the phosphoinositide response. Mol Cell Biochem 89, 187–189 (1989). https://doi.org/10.1007/BF00220774
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DOI: https://doi.org/10.1007/BF00220774