Abstract
The role of Ca2+ in the initiation and maintenance of contraction has been extensively studies. Many of these studies have focused on how Ca2+ influx and efflux affect cytoplasmic Ca2+ (Cai) and, therefore, contraction in cardiac muscle. However, it has recently become apparent that Cai itself may play a major role in the control of Ca2+ influx and efflux from cardiac muscle. Here we review current ideas on the mechanisms underlying Ca2+ homeostasis in cardiac muscle, with specific attention to how Cai may control Ca2+ influx, both under normal and pathological conditions.
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Kirby, M.S., Orchard, C. & Boyett, M.R. The control of calcium influx by cytoplasmic calcium in mammalian heart muscle. Mol Cell Biochem 89, 109–113 (1989). https://doi.org/10.1007/BF00220761
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DOI: https://doi.org/10.1007/BF00220761