Abstract
A male newborn showing congenital symmetrical abdominal skin defects and an alopecia on the scalp following a spiral pattern is described. The pattern of distribution of both skin anomalies was reminiscent of the lines of Blaschko, indicating that somatic mosaicism is the most probable cause for the defects.
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Blaschko A (1901) Die Nervenverteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut. Braumuller, Wien Leipzig
Demmel U (1975) Clinical aspects of congenital skin defects. Eur J Pediatr 121:21–50
Frieden IJ (1986) Aplasia cutis congenital a clinical review and proposal for classification. J Am Acad Dermatol 14:646–660
Hall JG (1988) Review and hypotheses: somatic mozaicism: observations related to clinical genetics. Am J Hum Genet 43:355–363
Happle R (1985) Lyonization and the lines of Blaschko. Hum Genet 70:200–206
Happle R, Fuhrmann-Rieger A, Fuhrmann W (1984) Wie verlaufen die Blaschko-Linien am behaarten Kopf? Hautarzt 35:366–369
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Hennekam, R.C.M. Aplasia cutis congenita reminiscent of the lines of Blaschko. Hum Genet 90, 469–471 (1992). https://doi.org/10.1007/BF00220481
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DOI: https://doi.org/10.1007/BF00220481