Summary
A portion of the “Gomori-positive” peptidergic neurosecretory (NS) cells in the paraventricular and especially in the supraoptic and postoptic nuclei degenerate three weeks after deafferentation of the medial basal hypothalamus. Most of the remaining NS cells show signs of high activity. Regenerating NS fibres form “muffs” around the blood vessels laterally from the lesion; some of them enter the “isolated” area or persist there if a thin layer of the brain tissue is left somewhere untouched under the basal end of the cut. The regenerating NS fibres are also found outside the nervous tissue: within the scar tissue, in the proliferating connective tissue of the brain sheet below the basal end of the cut and in the mantel plexus area. The NS fibres make close contact with blood vessels invading or penetrating the vascular wall. It is suggested that peptide neurohormones discharged from the “Gomoripositive” NS terminals enter the general blood circulation as well as the portal blood at the site of these newly formed axovasal contacts. It is supposed that under these conditions monoaminergic terminals do not discharge monoamines because no stimulation of monoamine-producing NS cells occurs with deafferentation.
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Dedicated to Prof. Berta Scharrer on the occasion of her birthday with respect for her outstanding contributions to science and warm human qualities
The authors wish to thank Prof. E.V. Naumenko, Dr. L.N. Maslova (Novosibirsk) and Prof. B.E. Ryzhenkov (Leningrad) for the opportunity to study this material, and Dr. I. Vermes (Pécs, Hungary) who deafferentated rats during his visit in Leningrad. The skillful technical assistance of Mrs. Liana Mocharuk is acknowledged. Thanks are due to Mrs. Rimma V. Polenova for valuable help in preparing the manuscript
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Danilova, O.A., Polenov, A.L. “Gomori-positive” neurosecretion in the rat after deafferentation of the medial basal hypothalamus. Cell Tissue Res. 176, 121–130 (1977). https://doi.org/10.1007/BF00220348
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DOI: https://doi.org/10.1007/BF00220348