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The microvascular pattern and perivascular linings of the area postrema

A combined freeze-etching and ultrathin section study

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Summary

The microvasculature and perivascular linings of the area postrema (A.P.) were studied electron microscopically with the ultrathin section and freeze-etching techniques. Special attention was given to the intercellular contacts of the different cellular entities. Two types of microvascular segments were identified. The endothelium of these vascular segments reveals fenestrations and a high pinocytotic activity. There are no significant differences in the frequency and distribution of the endothelial “openings” between both types of capillaries. The endothelium of the blood vessels, however, is joined by different types of tight junctions. Focal tight junctions occur between pericytes and the endothelium, and between leptomeningeal cellular elements in the perivascular space. The cell membrane of the perivascular glia shows intramembrane particles which are either distributed at random or organized in the form of membrane-associated orthogonal particle complexes (MOPC, Dermietzel, 1974). The significance of these findings is discussed with respect to the modified blood-brain barrier mechanism in the A.P.

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Authors and Affiliations

  1. Institut für Anatomie, Universitätsklinikum der Gesamthochschule Essen, Essen, Bundesrepublik Deutschland

    R. Dermietzel & A. G. Leibstein

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  1. R. Dermietzel
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  2. A. G. Leibstein
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Supported by a grant of the Deutsche Forschungsgemeinschaft (SFB 114 Bionach) to R. Dermietzel

The authors are indebted to Mrs. D. Schünke and Mr. R. Eichner for technical assistance and Mr. A. Stapper for preparing the diagram

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Dermietzel, R., Leibstein, A.G. The microvascular pattern and perivascular linings of the area postrema. Cell Tissue Res. 186, 97–110 (1978). https://doi.org/10.1007/BF00219657

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