Summary
Paneth cells containing zinc-rich granules were found in the small intestine of 6-day-old rats. These cells were more numerous in older animals and were consistently most common in the distal ileum. The zinc content of granules from 10-day-old rats was similar to that found in adults (ca 300 mg atoms/kg dry weight) but no calcium could be detected. An injection of cortisone acetate at 5 days resulted in a premature increase in the numbers of Paneth cells in 10-day-old rats. The cell granules contained normal, adult levels of zinc, a calcium concentration of ca 400 mg atoms/kg dry weight and also an increased concentration of phosphorus.
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Dinsdale, D., Biles, B. Postnatal changes in the distribution and elemental composition of Paneth cells in normal and corticosteroid-treated rats. Cell Tissue Res. 246, 183–187 (1986). https://doi.org/10.1007/BF00219016
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DOI: https://doi.org/10.1007/BF00219016