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Distribution of subgroups of noradrenaline neurons in the coeliac ganglion of the guinea-pig

Cell and Tissue Research volume 244, pages 173–180 (1986)Cite this article

Summary

The distributions within the coeliac ganglion of different chemically coded subgroups of noradrenaline neurons, and the relationships between these neurons and nerve fibres projecting to the ganglion from the intestine, have been assessed quantitatively by use of an immunohistochemical double-staining method. Noradrenaline (NA) neurons made up 99% of all cell bodies. Of these, 21% were also reactive for somatostatin (NA/SOM neurons), 53% were also reactive for NPY (NA/NPY neurons), and 26% were not reactive for either peptide. NA neurons without reactivity for any of the peptides whose localization was tested have been designated NA/-. A small percentage, about 1%, of neurons were reactive for both NPY and SOM. The three major types of NA neurons were arranged in clumps or ribbons throughout the ganglia, with a tendency for NA/SOM neurons to be medial and NA/NPY neurons to be lateral in the ganglia. A small group of neurons (<1%) encoded with dynorphin, NPY and vasoactive intestinal peptide (VIP) was encountered. VIP-immunoreactive nerve terminals, projecting to the ganglion from cell bodies in the intestine, ended around NA/SOM and NA/neurons but not around NA/NPY neurons. Thus, the VIP axons from the intestine end selectively around neurons that modify intestinal function (NA/SOM and NA/-neurons) but not around neurons, the terminals of which supply blood vessels (NA/NPY neurons).

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Affiliations

  1. Departments of Physiology and of Anatomy and Histology, and the Centre for Neuroscience, Flinders University, Bedford Park, S.A., Australia

    I. M. Macrae,  J. B. Furness & M. Costa

Authors
  1. I. M. Macrae
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  2. J. B. Furness
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  3. M. Costa
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Macrae, I.M., Furness, J.B. & Costa, M. Distribution of subgroups of noradrenaline neurons in the coeliac ganglion of the guinea-pig. Cell Tissue Res. 244, 173–180 (1986). https://doi.org/10.1007/BF00218395

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  • DOI: https://doi.org/10.1007/BF00218395

Key words

  • Autonomic ganglia
  • Coeliac ganglion
  • Vascular innervation
  • Intestinal innervation
  • Neuropeptides
  • Guinea-pig