Summary
Adrenal glands of adult male hamsters are larger and secrete more cortisol than those of females. Stereology was therefore used to study zonal and cellular aspects of development of the adrenal cortex of male and female hamsters. Adrenal glands were studied at weekly intervals from day 21 to day 77 of postnatal ontogenesis. Within this period, body weight did not differ significantly between the sexes. During development, absolute and relative adrenal weights were higher in males; their zona glomerulosa (ZG), zona fasciculata (ZF) and zona reticularis (ZR) become markedly larger than those in females. No marked changes in the volume of individual ZG cells occurred although ZF cells and ZR cells become larger in male than female animals. The total number of adrenocortical cells increased within the period studied, a greater increase being observed in ZG and ZF in males. No distinct sex difference was observed in the number of ZR cells throughout development. From day 56 of postnatal life the adrenal cortex of male hamster contained more parenchymal cells than the female gland. These results thus indicate that sex differences in hamster adrenal cortex depend upon changes in number and size of parenchymal cells.
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References
Bliss CI (1967) Statistics in biology, vol 1, McGraw-Hill, New York
Gaskin JH, Kitay JI (1970) Adrenocortical function in the hamster: Sex differences and effects of gonadal hormones. Endocrinology 87:779–786
Gaskin JH, Kitay JI (1971) Hypothalamic and pituitary regulation of adrenocortical function in the hamster: Effects of gonadectomy and gonadal hormone replacement. Endocrinology 89:1047–1053
Holmes AH (1927) Petrographic methods and calculations, 1st ed, Murby (Thomas) and Co. London
Holmes WN (1955) Histological variations in the adrenal cortex of the golden hamster with special reference to the X zone. Anat Rec 122:271–287
Ito T (1956) Postnatal histogenesis of the adrenal cortex of the golden hamster. Okajimas Folia Anat Jpn 29:67–91
Keyes PH (1949) Adreno-cortical changes in Syrian hamster following gonadectomy. Endocrinology 44:274–277
Kitay JI (1968) Effects of estrogen and androgen on the adrenal cortex of the rat. In: McKerns KW (ed) Functions of the adrenal cortex, vol II, Appleton-Century-Crofts New York, pp 775–811
Knigge KM (1954) The effect of hypophysectomy on the adrenal gland of the hamster (Mesocricetus auratus). Am J Anat 94:225–272
Kupperman HS, Greenblatt RB (1947) Relationship of sex steroids to the adrenal glands of hamster and rat. Endocrinology 40:452–461
Majchrzak M, Malendowicz LK (1983) Sex differences in adrenocortical structure and function. XII. Stereologic studies of rat adrenal cortex in the course of maturation. Cell Tissue Res 232:457–469
Malendowicz LK (1974) Sex differences in adrenocortical structure and function. II. The effects of postpubertal gonadectomy and gonadal hormone replacement on the rat adrenal cortex evaluated by stereology at the light microscope level. Cell Tissue Res 151:537–547
Malendowicz LK, Nikicicz H, Kasprzak A (1982a) Sex differences in adrenocortical structure and function. VIII. Karyometric and stereologic studies on adrenals of intact adult male and female hamsters. Z mikrosk-anat Forsch 96:81–90
Malendowicz LK, Kasprzak A, Nikicicz H (1982b) Sex differences in adrenocortical structure and function. IX. Stereologic studies on the effects of gonadectomy and testosterone or estradiol replacement on adrenal cortex of adult male and female hamsters. Z mikrosk-anat Forsch 96:91–102
Peczenik O (1944) Action of sex hormones on the adrenal cortex of the golden hamster. Proc Roy Soc Edinb B 62:59–65
Swanson HH (1967) Effects of pre-and post-pubertal gonadectomy on sex differences in growth, adrenal and pituitary weights of hamster. J Endocrinol 39:555–564
Swinyard CA (1939) Methods for volumetric determination of fresh endocrine glands. Anat Rec 74:71–78
Weibel ER (1979) Stereological methods, vol 1, Academic Press, London New York Toronto Sydney San Francisco
Weibel ER, Gomez DM (1962) A principle for counting tissue structure on random sections. J Appl Physiol 17:343–348
Zieger G, Lux B, Kubatsch B (1974) Sex dimorphism in the adrenal of hamsters. Acta Endocrinol (Kbh) 75:550–560
Zieger G, Schmitt A, Siebels C, Kubatsch B (1980) Histologische Veränderungen der Nebennierenrinde des syrischen Goldhamsters nach perinatal begonnener Sexualsteroidbehandlung. Anat Anz (Jena) 147:327–339
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Supported in part by a grant from the Committee of Zoology, Polish Academy of Sciences
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Nikicicz, H., Kasprzak, A. & Malendowicz, L.K. Sex differences in adrenocortical structure and function. Cell Tissue Res. 235, 459–462 (1984). https://doi.org/10.1007/BF00217874
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DOI: https://doi.org/10.1007/BF00217874