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Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia

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Abstract

We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (χ2= 13.46, 2 df, P<0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.

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References

  • Chen JH (1985) The proto-oncogene c-ets is preferentially expressed in lymphoid cells. Mol Cell Biol 5: 2993–3000

    Google Scholar 

  • Ciulla TA, Sklar RM, Hauser SL (1988) A simple method for DNA purification from peripheral blood. Anal Biochem 174: 485–488

    Google Scholar 

  • Concannon P, Malhotra U, Charmley P, Reynolds J, Lange K, Gatti RA (1990) The ataxia-telangiectasia gene (ATA) on chromosome 11 is distinct from the ETS-1 gene. Am J Hum Genet 46: 789–794

    Google Scholar 

  • Cooper DN, Smith BA, Cooke HJ, Niemann S, Schmidtke J (1985) An estimate of unique DNA sequence heterozygosity in the human genome. Hum Genet 69: 201 -205

    Google Scholar 

  • Crossen PE, Horn HL (1987) Origin of trisomy 12 in B-cell chronic lymphocytic leukaemia. Cancer Genet Cytogenet 28: 185–186

    Google Scholar 

  • Crossen PE, Morrison MJ (1992) XbaI RFLP of Ets-I oncogcne in chronic B-cell leukaemia. Leukaemia 6: 843–844

    Google Scholar 

  • Gerhard DS, Dracopoli NC, Bale SJ, Houghton AN, Watkins P, Payne CE, Grecne MH, Housman DE (1987) Evidence against Haras-1 involvement in sporadic and familial melanoma. Nature 325: 73–75

    Google Scholar 

  • Heighway J, Thatcher N, Cerny T, Hasleton PS (1986) Genetic predisposition to human lung cancer. Br J Cancer 53: 453–457

    Google Scholar 

  • Junien C, Heyningen V van (1991) Report of the committee on the genetic constitution of chromosome 11. Cytogenet Cell Genet 58: 459–554

    Google Scholar 

  • Kerckaert JP, Duterque-Coquillaud M, Collyn-d'Hooghe M, Morel P, Majerus MA, Lai JL, Fenaux P, Bauters F, Debuire B, Locheux-Lefebvre MH (1990) Polymorphism of the proto-oncogene ETS-1 in hematological malignancies. Leukaemia 4: 16–19

    Google Scholar 

  • Krontiris TG, DiMartino NA, Colb M, Parkinson DR (1985) Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients. Nature 313: 369–373

    Google Scholar 

  • Kawashima K, Shikama H, Imoto K, Izawa M, Naruke T, Okabayushi K, Nishimura S (1988) Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs. Proc Natl Acad Sci USA 85: 2353–2356

    Google Scholar 

  • Liderau R, Mathieu-Mahul D, Theillet C, Renaud M, Mauchauffe M, Gest J, Larsen C-J (1985) Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients. Proc Natl Acad Sci USA 82: 7068–7070

    Google Scholar 

  • Liderau R, Escot C, Theillet C, Champeme M-H, Brunet M, Gest J, Callahan R (1986) High frequency of rare alleles of the human c-Ha-ras-1 proto-oncogene in breast cancer patients. J Natl Cancer Inst 77: 697–701

    Google Scholar 

  • Mitelman F, Maneko Y, Trent JM (1990) Report of the committee on chromosome changes in neoplasia. Cytogenet Cell Genet 55: 358–386

    Google Scholar 

  • Taisne C de, Gegonne A, Stehelin D, Bemheim A, Berger R (1984) Chromosomal localization of the human proto-oncogene c-ets. Nature 310: 581–589

    Google Scholar 

  • Tefre T, Borresen A-L, Aamdal S, Brogger A (1990) Studies of the L-myc DNA polymorphism and relation to metastasis in Norwegian lung cancer patients. Br J Cancer 61: 809–812

    Google Scholar 

  • Thein SL, Ozcier DG, Flint J, Wainscoat JS (1986) Ha-ras hypervariable alleles in myelodysplasia. Nature 321: 84–85

    Google Scholar 

  • Willard HF, Skolnick MH, Pcarson PL, Mandel J-L (1985) Report of the committee on human gene mapping by recombinant DNA techniques. (8th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 40: 360–489

    Google Scholar 

  • Williamson R, Bowcock A, Kidd K, Pearson P, Schmidtke J, Chan HS, Chipperfield M, Cooper DN, Hewitt J, Lewitter F, Maidak B, Quitt M, Ricciuti F, Track R (1990) Report of the DNA committee and catalogues of cloned and mapped genes and DNA polymorphisms. Cytogenet Cell Genet 55: 457–778

    Google Scholar 

  • Wylie FS, Wynford-Thomas V, Lemoine NR, Williams GT, Williams ED, Wynford-Thomas D (1988) Ha-ras restriction fragment length polymorphisms in colorectal cancer. Br J Cancer 57: 135–138

    Google Scholar 

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Authors and Affiliations

  1. Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, Christchurch, New Zealand

    Peter E. Crossen & Mary J. Morrison

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  1. Peter E. Crossen
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  2. Mary J. Morrison
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Crossen, P.E., Morrison, M.J. Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia. Hum Genet 91, 380–382 (1993). https://doi.org/10.1007/BF00217361

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  • DOI: https://doi.org/10.1007/BF00217361

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