Abstract
The effect of a selective ℵ-opioid agonist, U-50, 488H, on wet-dog shaking (WDS) induced by hippocampal stimulation was investigated and compared with that produced by morphine. U-50, 488H, as well as morphine, inhibited the appearance of WDS in a dose-dependent manner. U-50, 488H was approximately three times more potent than morphine in this effect. Neither drug showed any effect on hippocampal afterdischarge. The inhibition of WDS produced by U-50, 488H was blocked significantly by a ℵ-opioid antagonist, MR-2266, but not by naloxone. On the other hand, the inhibitory effect of morphine was completely antagonized by both MR-2266 and naloxone. The present results strongly suggest that not only μ-but also ℵ-opioid receptors are involved in the appearance of WDS induced by hippocampal stimulation.
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Ohno, M., Yamamoto, T., Araki, H. et al. The effect of ℵ-opioid agonist U-50, 488H on wet-dog shaking behavior induced by hippocampal stimulation in rats. Psychopharmacology 91, 189–192 (1987). https://doi.org/10.1007/BF00217060
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DOI: https://doi.org/10.1007/BF00217060