Summary
Most renin-positive cells of the preglomerular arteriole are intermediate in morphological appearence between smooth muscle cells and epithelioid cells. Intermediate cells contain, in addition to secretory granules, contractile proteins arranged as a sublemmal network. The paradoxical (inhibitory) role of calcium in renin secretion is explained, on the basis of these findings, by an increased tone of the sublemmal network; this might impair the preexocytotic access of renin granules to the cell membrane.
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This study was supported by the ‘Deutsche Forschungsgemeinschaft’ within the ‘Forschergruppe Niere, Heidelberg’
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Taugner, R., Nobiling, R., Metz, R. et al. Hypothetical interpretation of the calcium paradox in renin secretion. Cell Tissue Res. 252, 687–690 (1988). https://doi.org/10.1007/BF00216658
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DOI: https://doi.org/10.1007/BF00216658