Abstract
The Tcrb-V10b+ T cell population has been examined with a newly established antibody, KT10b, specific for Tcrb-V10b but not Tcrb-V10a. H-2E+ mice have higher levels of Tcrb-V10b+ T cells (4.3%–11.%) than H-2E− mice (2.2%–4.9%). This difference appears to be determined by levels of Tcrb-V10b+ T cells in the CD4 population. F1 mice between H-2E+ and H-2E− mice dominantly express higher levels of Tcrb-V10b+ T cells. [NOD (E−) x (NOD x A (E+))F1] backcross mice show positive selection of Tcrb-V10b+ CD4+ T cells by H-2E. On the other hand other backcross analyses reveal positive selection of Tcrb-V10b+ CD8+ T cells by certain major histocompatibility class I molecules. Involvement of non-H-2 antigens in these positive selections remain to be determined.
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Tomonari, K., Hederer, R. & Hengartner, H. Positive selection of Tcrb-V10b+ T cells. Immunogenetics 35, 9–15 (1992). https://doi.org/10.1007/BF00216621
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DOI: https://doi.org/10.1007/BF00216621