Psychopharmacology

, Volume 96, Issue 3, pp 343–352 | Cite as

Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective μ and δ opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes

  • Valérie Dauge
  • Paul Rossignol
  • Bernard P. Roques
Original Investigations

Abstract

The effects of selective agonists for δ opioid receptors: [D-Thr2, Leu5]-enkephalyl-Thr6 (DTLET) and μ receptors: [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO) and of (R)-3-(N-hydroxyl-carboxamido-2-benzylpropanoyl)-L-alanine (kelatorphan), a complete inhibitor of enkephalin degrading enzymes, on the motor activity of rats was examined after their local administration into the nucleus accumbens (NA) or nucleus caudatus (NC). In both structures DTLET dose dependently enhanced locomotor activity as measured in the open-field test. This strong effect was reversed by the selective δ antagonist: ICI 174,864. Contrastingly, DAGO induced hypoactivity followed by hyperactivity 150 min later. This biphasic effect was blocked by systemic injection of naloxone, but not by ICI 174,864. The physiological relevance of these effects was ascertained by the naloxone-reversible stimulatory responses induced by kelatorphan, supporting a role for endogenous enkephalins in the control of behavior through δ receptor stimulation.

Key words

μ, δ opioid receptors Inhibition of enkephalin catabolism Nucleus accumbens Nucleus caudatus Motor behavior Kelatorphan DAGO DTLET Rat 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Valérie Dauge
    • 1
  • Paul Rossignol
    • 1
  • Bernard P. Roques
    • 2
  1. 1.Laboratoire de PharmacologieUER des Sciences Pharmaceutiques et BiologiquesParisFrance
  2. 2.Département de Chimie OrganiqueU 266 INSERM, UA 498 CNRS, UER des Sciences Pharmaceutiques et BiologiquesParisFrance

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