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Sabeluzole (R 58 735) increases consistent retrieval during serial learning and relearning of nonsense syllables

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Abstract

Consistent retrieval during serial learning of nonsense syllables was investigated under sabeluzole (10 mg b.i.d. for 7 days) and placebo. The same material was relearned 1 week after withdrawal of the drug. During learning a twofold improvement in retrieval efficiency was seen when volunteers learned new material under steady-state levels of sabeluzole. During relearning, material originally learned under sabeluzole was significantly better retrieved than material learned under placebo. The results suggest that sabeluzole influences basic mechanisms involved in storage and retrieval of new information.

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References

  • Buschke H, Fuld PA (1974) Evaluating storage, retention and retrieval in disordered memory and learning. Neurology 24:1019–1025

    Google Scholar 

  • Clincke GHC, Tritsmans L (1988) Effects of R 58 735 on learning and memory functions. In: Gruneberg MM, Morris PE, Sykes RN (eds) Practical aspects of memory: current research and issues, vol 2 — Clinical and educational implications. Wiley, Chichester New York Brisbane Toronto Singapore, pp 211–216

    Google Scholar 

  • Clincke GHC, Tritsmans L, Idzikowski C, Amery WK, Janssen PAJ (1988) The effect of R 58 735 (sabeluzole) on memory functions in healthy elderly volunteers. Psychopharmacology 94:52–57

    Google Scholar 

  • Tritsmans L, Clincke G, Amery WK (1988) The effect of sabeluzole (R 58 735) on memory retrieval functions. Psychopharmacology 94:527–531

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Clincke, G.H.C., Tritsmans, L. Sabeluzole (R 58 735) increases consistent retrieval during serial learning and relearning of nonsense syllables. Psychopharmacology 96, 309–310 (1988). https://doi.org/10.1007/BF00216055

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  • DOI: https://doi.org/10.1007/BF00216055

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