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A possible mosaic form of delayed centromere separation and aneuploidy

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Summary

On average, a “normal” centromere separation sequence was seen in 3 neonates with trisomy 18 and in their parents. When evaluating individual mitoses, unusually late separating chromosomes 18 were found in a few cells of one of the parents in each family. A possible germline mosaicism of delayed separation in the parent may account for trisomy in the offspring.

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Authors and Affiliations

  1. Department of Paediatrics, University Medical School of Pécs, József Attila u. 7, H-7623, Pécs, Hungary

    Károly Méhes & György Kosztolányi

Authors
  1. Károly Méhes
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  2. György Kosztolányi
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Méhes, K., Kosztolányi, G. A possible mosaic form of delayed centromere separation and aneuploidy. Hum Genet 88, 477–478 (1992). https://doi.org/10.1007/BF00215686

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  • DOI: https://doi.org/10.1007/BF00215686

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