Summary
Growth failure starting before birth is a common characteristic in Turner syndrome, and its pathogenesis is still not completely explained. Experiments performed in mice and rats to test whether a genetic disparity between mothers and offspring and maternal immunological status have any influence on litter size have demonstrated that allogenic litters are significantly larger in size than genetically compatible ones. Studies in humans have given contrasting results, but some authors have found that heterozygosity at enzyme loci and in blood groups is positively correlated with intrauterine growth. HLA class I and II polymorphisms were defined in 53 patients with Turner syndrome and in their parents, and lymphocytotoxic antibody detection was performed in 36 mothers. These data were related to the patients' birth weight. The frequency of the HLA-B16 allele in patients with a birth weight > 10th centile was significantly higher in comparison with those < 10th centile. HLA antigen sharing was present in 43 couples (81.1%). Mean birth weight was 2934 ± 472 g in patients without HLA antigen parental sharing and 2721 ± 529 g in those whose parents shared HLA antigens. The mean birth weight of the 10 patients whose parents do not share HLA antigens was significantly higher than that of the patients with parental HLA−B+DR sharing (P < 0.05) and not significantly higher than in those patients with parental HLA sharing at other HLA loci. Patients whose parents shared B+DR antigens also had significantly smaller birth weights than those with B and A+B+DR sharing (P < 0.025 and P < 0.025). No significant difference in mean birth weight was found in relation to other parameters, such as mother-child histocompatibility, HLA homozygosity and lymphocytotoxic production in the mothers.
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References
Astolfi P, Martinetti M, Gigli-Berzolari F, Cuccia M (1990) The effect of parental and maternal-fetal histocompatibility at MHC on sex ratio in offspring. Tissue Antigens 35:172–177
Beer AE, Billingham RE (1977) Histocompatibility gene polymorphisms and maternal-fetal interactions. Transplant Proc 9:1393–1401
Beer AE, Scott JR, Billingham RE (1975) Histocompatibility and maternal immunological status as determinants of fetoplacental weight and litter size in rodents. J Exp Med 142:180–196
Bolis PF, Martinetti-Bianchi M, Soro V, Belvedere M (1984) HLA typing in couples with repetitive abortion. Biol Res Pregn 5:135–137
Bottini E, Gloria-Bottini F, Lucarelli P, Polzonetti A, Santoro F, Varveri A (1979) Genetic polymorphisms and intrauterine development. Evidence of decreased heterozygosity in light-for-dates human newborn babies. Experientia 35:1565–1567
Brook CDG, Murset G, Zachmann M, Prader A (1974) Growth in children with 45,X0 Turner's syndrome. Arch Dis Child 49:789–795
Carr-Hill R, Campbell DM, Hall MH, Meredith A (1987) Is birth weight determined genetically? Br Med J 295:687–689
Cothran EG, Chesser RK, Smith MH, Johnson PE (1983) Influences of genetic variability and maternal factors on fetal growth in white-tailed deer. Evolution 37:282–291
Cuccia M, Martinetti M, Larizza D, Bolis PF, Severi F (1990) Excess of HLA parental sharing in families with Turner patients. Clin Genet 38:415–421
David CS (1989) Major histocompatibility genes and reproduction. Am J Reprod Immunol 21:26–27
Dupont B (ed) (1989) Immunobiology of HLA. Springer, New York Berlin Heidelberg
Gautschi C, Gaillard C (1990) Influence of major histocompatibility complex on reproduction and production traits in swine. Anim Genet 21:161–170
Gloria-Bottini F, Lucarini N, Falsi AM, Orzalesi M, Bottini E (1980) Rare phenotypes of placental alkaline phosphatase. An analysis of relationships with some neonatal and maternal variables. Hum Genet 54:103–105
Guerrini P, Candini G, Parmagnani M, Garani GP, Semerari A, Semeraro M, Bosi G (1986) Curve dell'accrescimento endouterino da 26 a 42 settimane di gravidanza. Riv Ital Ped 12:79–84
Jazwinska EC, Kilpatrick DC, Smart GE, Liston WA (1987) Fetomaternal HLA compatibility does not have a major influence on human pregnancy except for lymphocytotoxin production. Clin Exp Immunol 68:116–122
Koehn RK, Gaffney PM (1984) Genetic heterozygosity and growth rate in Mytilus edulis. Mar Biol 82:1–7
Kunz HW, Gill TJIII, Dixon BD, Taylor FH, Greiner DL (1980) Growth and reproduction complex in the rat. Genes linked to the major histocompatibility complex that affect development. J Exp Med 152:1506–1518
Larizza D, Martinetti Bianchi M, Lorini R, Maghnie M, Dugoujon JM, Cuccia Belvedere M, Severi F (1989) Autoimmunity, HLA, Gm and Km polymorphisms in Turner's syndrome. Autoimmunity 4:69–78
Lerner SP, Anderson CP, Walford RL, Finch CE (1988) Genotypic influences on reproductive aging of imbred female mice: effects of H-2 and non-H-2 alleles. Biol Reprod 38:1035–1043
Martinetti M, Astolfi P, Bolis PF, Coronelli M, Cuccia M (1989) Reproductive performances: HLA homozygous conditions in healthy and affected sibships (abstract). J Reprod Immunol [Suppl]:111
Ober CL, Martin AO, Simpson JL, Hauck WW, Amos DB, Kostyu DD, Fotino M, Allen FH Jr (1983) Shared HLA antigens and reproductive performance among Hutterites. Am J Hum Genet 35:994–1004
Pierce BA, Mitton JB (1982) Allozyme heterozygosity and growth in the tiger salamander, Ambystoma tigrinum. J Hered 73:250–253
Power DA, Catto GRD, Mason RJ, Macleod AM, Stewart GM, Stewart KN, Shewan WG (1983) The fetus as an allograft evidence for protective antibodies to HLA-linked paternal antigens. Lancet II:701–704
Ranke MB, Pfluger H, Rosendahl W, Stubbe P, Enders H, Bierich JR, Majewski F (1983) Turner syndrome: spontaneous growth in 150 cases and review of the literature. Eur J Pediatr 141:81–88
Ranke MB, Stubbe P, Majewski F, Bierich JR (1988) Spontaneous growth in Turner syndrome. Acta Paediatr Scand 343 [Suppl]:22–30
Rappaport R, Sauvion S (1989) Possible mechanism for the growth retardation in Turner's syndrome. Acta Paediatr Scand 356 [Suppl]:82–86
Roberts DF (1981) Genetics of growth. Br Med Bull 37:239–246
Robson EB (1978) The genetics of birth weight. In: Falkner F, Tanner JM (eds) Human growth, vol 1: Principles and prenatal growth. Plenum Press, NewYork London, pp 285–297
Rothschild MF, Renard C, Bolet G, Dando P, Vaiman M (1986) Effect of swine lymphocyte antigen haplotypes on birth and weaning weights in pigs. Anim Genet 17:267–272
Stear MJ, Pokorny TS, Muggli NE, Stone RT (1989) The relationship of birth weight, preweaning gain and postweaning gain with the bovine major histocompatibility system. J Anim Sci 67:641–649
Tiwari JL, Terasaki PI (1985) Typing methodology. In: Tiwari JL, Terasaki PI (eds) HLA and disease associations. Springer, Tokyo Berlin Heidelberg, pp 14–17
Verp MS, Rosinsky B, Le Beau MM, Martin AO, Kaplan R, Wallemark C-B, Otano L, Simpson JL (1988) Growth disadvantage of 45,X and 46,X,del(X)(p11) fibroblasts. Clin Genet 33:277–285
Ward RD, Sarfarazi M, Azimi-Garakani C, Beardmore JA (1985) Population genetics of polymorphisms in Cardiff newborn. Relationship between blood group and allozyme heterozygosity and birth weight. Hum Hered 35:171–177
Warner CM, Brownell MS, Ewoldsen MA (1988) Why aren't embryos immunologically rejected by their mothers? Biol Reprod 38:17–29
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Larizza, D., Martinetti, M., Pizzochero, C. et al. Influence of HLA genotype on birth weight of patients with Turner syndrome. Hum Genet 88, 383–387 (1992). https://doi.org/10.1007/BF00215670
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DOI: https://doi.org/10.1007/BF00215670