Abstract
Genes encoding superantigens which delete Tcrb-V3+ T cells co-segregate with mouse mammary tumor proviruses (Mtv), Mtv-1, Mtv-3, Mtv-6, Mtv-13, and Mtv-44. We have examined percentages of Tcrb-V3+ T cells and Mtv integrations in [(B10 × NZB)F1 × B10.BR] mice, and show that Mtv-27 as well as Mtv-3 from NZB mice co-segregate with genes encoding deletion ligands for Tcrb-V3+ T cells without recombination.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Acha-Orbea, H. -and Palmer, E.: Mls — a retrovirus exploits the immune system. Immunol Today 12: 356–361, 1991
Acha-Orbea, H., Shakhov, A. N., Scarpellino, L., Kolb, E., Muller, V., Vessaz-Shaw, A., Fuchs, R., Blochlinger, K., Rollini, P., Billotte, J., Sarafidou, M., MacDonald, H. R., and Diggelmann, H.: Clonal deletion of Vβ14-bearing T cells in mice transgenic for mammary tumour virus. Nature 350: 207–211, 1991
Beutner, U., Rudy, C., and Huber, B. T.: Molecular characterization of Mls-1. Int Rev Immunol, in press, 1992
Callahan, R., Drohan, W., Gallahan, D., D'Hoostelaere, L., and Potter, M.: Novel class of mouse mammary tumor virus-related DNA sequences found in all species of Mus, including mice lacking the virus proviral genome. Proc Natl Acad Sci USA 79: 4113–4117, 1982
Cazenave, P.-A., Marche, P. N., Jouvin-Marche, E., Voegtle, D., Bonhomme, F., Bandeira, A., and Coutinho, A.: Vβ17 gene polymorphism in wild-derived mouse strains: two amino acid substitutions in the Vβ17 region greatly alter T cell receptor specificity. Cell 63: 717–728, 1990
Choi, Y., Kappler, J. W., and Marrack, P.: A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus. Nature 350: 203–207, 1991
Dyson, P. J., Knight, A. M., Fairchild, S., Simpson, E., and Tomonari, K.: Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes. Nature 349: 531–532, 1991
Eicher, E. M. and Lee, B. K.: The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci. Genetics 125: 431–446, 1990
Fairchild, S., Knight, A. M., Dyson, P. J., and Tomonari, K.: Cosegregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3. Immunogenetics 34: 227–230, 1991
Fairchild, S., Rosenwasser, O. A., Dyson, P. J., and Tomonari, K.: Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44, Immunogenetics 36: 189–194, 1992
Frankel, W. N., Rudy, C., Coffin, J. M., and Huber, B. T.: Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature 349: 526–528, 1991
Hillyard, A. L., Doolittle, D. P., Davisson, M. T., and Roderick, T. H.: Locus map of mouse. Mouse Genome 89: 16–30, 1991
Kappler, J. W., Roehm, N., and Marrack, P.: T cell tolerance by clonal elimination in the thymus. Cell 49: 273–280, 1987
Kappler, J. W., Staerz, U., White, J., and Marrack, P. C.: Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35–40, 1988
Lee, B. K. and Eicher, E. M.: Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets. J Virol 64: 4568–4572, 1990
MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R. M., and Hengartner, H.: T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 332: 4045, 1988
Maniatis, T., Fritsch, E. F., and Sambrook, J.: Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1982
Marrack, P., Kushnir, E., and Kappler, J.: A maternally inherited superantigen encoded by a mouse mammary tumor virus. Nature 349: 524–526, 1991
Pullen, A. M., Marrack, P., and Kappler, J. W.: The T cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335: 796–801, 1988
Pullen, A. M., Wade, T., Marrack, P., and Kappler, J.: Identification of the region of T cell receptor β-chain that interacts with the self-superantigens Mls-1a. Cell 61: 1365–1374, 1990
Pullen, A. M., Choi, Y., Kushnir, E., Kappler, J., and Marrack, P.: The open reading frames in the 3′ long terminal repeats of several mouse mammary tumor virus integrants encode Vβ3-specific superantigens. J Exp Med 175: 41–47, 1992
Tomonari, K. and Fairchild, S.: The genetic basis of negative selection of Tcrb-V11+ T cells. Immunogenetics 33: 157–162, 1991
Tomonari, K. and Fairchild, S.: Positive and negative selection of Tcrb-V6+ T cells. Immunogenetics 36: 230–237, 1992
Tomonari, K. and Spencer, S.: Epitope specific binding of CD8 regulates activation of T cells and induction of cytotoxicity. Int Immunol 2: 1189–1194, 1990
Woodland, D., Happ, M. P., Bill, J., and Palmer, E.: Requirement for co-tolerogenic gene products in the clonal deletion of I-E reactive T cells. Science 247: 964–967, 1990
Woodland, D. L., Happ, M. P., Gollob, K. J., and Palmer, E.: An endogenous retrovirus mediating deletion of αβ T cells? Nature 349: 529–530, 1991a
Woodland, D. L., Lund, F. E., Happ, M. P., Blackman, M. A., Palmer, E., and Corley, R. B.: Endogenous superantigen expression is controlled by mouse mammary tumor provial loci. J Exp Med 174: 1255–1258, 1991b
Author information
Authors and Affiliations
Additional information
Adress correspondence and offprint requests to: K. Tomari.
Rights and permissions
About this article
Cite this article
Tomonari, K., Fairchild, S. & Rosenwasser, O.A. Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27 . Immunogenetics 36, 302–305 (1992). https://doi.org/10.1007/BF00215658
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00215658