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Human growth hormone: 1974–1981

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Summary

Chemical investigations of the human growth hormone (HGH) molecule were briefly reviewed for the period between 1974 and 1981. These include chemical modification, selective enzymic cleavage, the 20K HGH, synthetic peptide fragments, complementation of the natural NH2 terminal 134-amino acid fragment with natural or synthetic COO H-terminal fragments of various chain lengths, covalent reconstitution of two contiguous fragments of HGH with thrombin and bacterially synthesized methionyl-HGH.

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Abbreviations

GH:

growth hormone or somatotropin

HGH:

human GH

CD:

circular dichroism

NMR:

nuclear magnetic resonance

DEAE:

diethylaminoethyl

CMC:

carboxymethyl cellulose

HPLC:

high performance liquid chromatography

RA-HGH:

reduced-carbamidomethylated HGH

PL-HGH:

plasmin-modified HGH

Cam:

Carbamidomethyl

BGH:

bovine GH

SDS:

sodium dodecylsulfate

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  1. Hormone Research Laboratory, University of California, 94143, San Francisco, CA, U.S.A.

    Choh Hao Li

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Li, C.H. Human growth hormone: 1974–1981. Mol Cell Biochem 46, 31–41 (1982). https://doi.org/10.1007/BF00215579

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